Neoadjuvant Chemotherapy Followed by Cesarean Radical Hysterectomy in a Triplet Pregnancy Complicated by Clear Cell Carcinoma of the Cervix: A Case Presentation and Literature Review

Ayhan, Ali; Dursun, Polat; Karakaya, Burcu Kisa; Özen, Özlem; Tarhan, Nefise Çağla

doi:10.1097/igc.0b013e31825e0d5a

Cited by 9 publications

(6 citation statements)

References 25 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2,26 Up to the end of 2012, 24 small studies and case reports had been published on this issue, and only a few have been added in subsequent months. 27,28 According to international recommendations, the prognosis in women with early cervical cancer does not seem to be worsened by either pregnancy itself or by delay to await fetal viability. 29,30 However, rapid cancer progression after delay of oncological therapy is also reported.…”

Section: Commentmentioning

confidence: 98%

“…38,39 The dosage used for nearly all patients in the present study is exactly in this range, whereas the number of applied cycles mainly depends on the time of the cancer diagnosis. 26,27,40 Because of a lack of data, it is not decided yet whether neoadjuvant monotherapy using cisplatinum or carboplatinum is inferior to any combination with paclitaxel, 5-fluorouracil, or vincristine. 2 Platinum is an effective drug in the treatment of patients diagnosed with cervical cancer.…”

Section: Commentmentioning

confidence: 99%

See 1 more Smart Citation

How much platinum passes the placental barrier? Analysis of platinum applications in 21 patients with cervical cancer during pregnancy

Köhler

Oppelt

Favero

et al. 2015

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

Section: Commentmentioning

confidence: 98%

Section: Commentmentioning

confidence: 99%

How much platinum passes the placental barrier? Analysis of platinum applications in 21 patients with cervical cancer during pregnancy

Köhler

Oppelt

Favero

et al. 2015

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

“…Cervical cancer is among the most common cancers in pregnant women, however, with 4 per 100,000 pregnancies its incidence is rather low [4]. In addition, adenocarcinoma of the uterine cervix during pregnancy is even rarer [5]. Thyroid cancers in pregnancy are rare.…”

Section: Discussionmentioning

confidence: 99%

“…Volume 3(11): 3-3 following termination of pregnancy by either abortion or delivery. Effects of chemotherapy during pregnancy on a child are still controversial [5,9]. Chemotherapy during pregnancy may be associated with teratogenic effects on the fetus and the risk of miscarriage.…”

mentioning

confidence: 99%

Cervical Adenocarcinoma in Pregnancy with a Concomitant Papillary Adenocarcinoma of the Thyroid Gland: A Case Report

Bolla¹,

Putora²,

Kolb³

et al. 2020

SCR

View full text Add to dashboard Cite

Introduction: Cervical cancer in pregnancy is a rare disease, with an incidence of 0.01-0.1%, of which most are squamous epithelial cancers. We here present the first case of a uterine cervical adenocarcinoma during pregnancy with a concomitant papillary adenocarcinoma of the thyroid gland. Materials and Methods: Data were extracted from the patient’s records. Literature review was performed using the databases PubMed, Web of science and Embase. Case Report: A 36-year-old Gravida IV, Para III was admitted to the Cantonal Hospital St. Gallen, Switzerland with an invasive adenocarcinoma of the uterine cervix cT1B2 cNx Mx G1 ER neg PR neg Ki67 80% at 31 weeks of gestation. She was treated with 2 cycles of neoadjuvant chemotherapy (carboplatin and paclitaxel). Following caesarean section at 36 2/7 weeks of gestation, treatment was switched to chemoradiation therapy. The patient delivered a healthy girl. A concomitant papillary thyroid cancer pT1a, pN1a (1/6) was successfully treated by surgery. The patient is free of recurrence and metastasis at 4.5 years of follow-up for either of the tumors. Conclusion: Management of cervical cancers in pregnancy has to be individualized based on factors like gestational age, stage and histology of the cancer, and the wish for pregnancy continuation or termination. Neoadjuvant chemotherapy seems to be a reasonable option to postpone radical surgery or chemoradiotherapy to prevent preterm delivery. To the best of our knowledge, this is the first report of a cervical adenocarcinoma in pregnancy with a concomitant papillary thyroid cancer.

show abstract

“…Only 25 cases of neoadjuvant chemotherapy during stage IB1 have been documented. Again, there are few studies reporting long-term follow-up ( 51 , 53 , 54 , 55 , 56 ).…”

Section: Pre-invasive and Invasive Lesions Of The Cervix During Pregnmentioning

confidence: 99%

Current management of gynecologic cancer in pregnancy

Iavazzo¹,

Minis²,

Gkegkes³

2018

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

Cancer during pregnancy is a particularly challenging complication. The incidence has increased in recent years due to childbearing at advanced maternal ages due to career choices and/or the development of reproductive technology. Approximately two thirds of cancer cases during pregnancy comprise invasive cervical cancers and breast cancer. Cancer during gestation is characterized by a need for specialized treatment due to major changes in the hormonal profile (estrogen-progesterone), metabolism (enhancement of anabolism), hemodynamic changes (hyperdynamic circulation), immunologic changes (cell-mediated and humoral immunity), and increased angiogenesis (increased blood flow towards the uterus). Moreover, the management of such patients is based on the trimester of pregnancy, type and stage of cancer, and informed consent of the mother based on her wishes. The optimal treatment of cancer during pregnancy remains elusive because there are limited data from retrospective studies with small samples. As a result, it is crucial that data regarding survival of the women and long-term follow-up of the children from different cancer centers and registries are shared. This need is dictated by the fact that the incidence of cancer during pregnancy will continue to rise as child-bearing age continues to increase.

show abstract

Neoadjuvant Chemotherapy Followed by Cesarean Radical Hysterectomy in a Triplet Pregnancy Complicated by Clear Cell Carcinoma of the Cervix: A Case Presentation and Literature Review

Cited by 9 publications

References 25 publications

How much platinum passes the placental barrier? Analysis of platinum applications in 21 patients with cervical cancer during pregnancy

How much platinum passes the placental barrier? Analysis of platinum applications in 21 patients with cervical cancer during pregnancy

Cervical Adenocarcinoma in Pregnancy with a Concomitant Papillary Adenocarcinoma of the Thyroid Gland: A Case Report

Current management of gynecologic cancer in pregnancy

Contact Info

Product

Resources

About