Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis
YiWen Fan,
Jill Moser,
Matijs van Meurs
et al.
Abstract:Background
Sepsis and acute respiratory distress syndrome (ARDS) are both associated with high morbidity and mortality, primarily due to systemic inflammation-induced tissue damage, resulting organ failure, and impaired recovery. Regulated extracellular matrix (ECM) turnover is crucial for maintaining tissue homeostasis in health and in response to disease-related changes in the tissue microenvironment. Conversely, uncontrolled turnover can contribute to tissue damage. Systemic Inflammation is implicated to p… Show more
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