Neo-clerodane diterpenoids from Croton schiedeanus

Puebla, Pilar; López, J. L.; Guerrero, Mario; Carrón, Rosalı́a; Martı́n, Ma Luisa; Román, Luís San; Feliciano, Arturo San

doi:10.1016/s0031-9422(02)00516-2

Cited by 34 publications

(28 citation statements)

References 8 publications

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“…54 Methyl barbascoate is a transclerodane found as major diterpene in leaves of C. californicus. 55 From shoots of C. schiedeanus, Puebla et al 56 and Guerrero et al 57 isolated cis-and transdehydrocrotonin and the new neo-clerodanes 5β-hydroxy-cis-dehydrocrotonin and (12R)-12-hydroxycascarillone. The acid fraction of shoot extracts of C. schiedeanus yielded two new cis-clerodanes (-)-methyl-16-hydroxy-19-nor-2-oxo-cis-cleroda-3,13-dien-15,16-olide-20-oate and (+)-15-methoxyfloridolide A.…”

Section: Diterpenesmentioning

confidence: 99%

Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae)

Salatino¹,

Salatino²,

Negri³

2007

J. Braz. Chem. Soc.

377

316

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Croton é um gênero de Euphorbiaceae com cerca de 1300 espécies, amplamente distribuídas em regiões tropicais do Novo e Velho Mundos. Várias espécies há muito tempo desempenham papel importante nos usos tradicionais de plantas medicinais na África, Ásia e América do Sul. Tais usos incluem tratamento de câncer, constipação intestinal, diarréia e outros problemas digestivos, diabetes, feridas externas, febre, hipercolesterolemia, hipertensão, inflamação, vermes intestinais, malária, dor, úlceras e obesidade. Várias espécies de Croton têm um látex vermelho que contém, em algumas espécies, pró-antocianidinas e/ou alcalóides. Os alcalóides de Croton são a taspina ou substâncias relacionadas a benzilisoquinolinas. Os diterpenos são muito comuns em Croton, correspondendo a clerodanos, cembranóides, halimanos, cauranos, labdanos, ésteres do forbol, traquilobanos e sarcopetalanos. Algumas espécies são aromáticas, devido à presença de óleos voláteis. Representantes de novas classes de substâncias (fenilbutanóides, alcalóides glutarimidínicos e diterpenos sarcopetalanos) têm sido isoladas de espécies de Croton. Enquanto laticíferos têm sido descritos em espécies de Croton, até o momento não há estudos anatômicos sobre estruturas secretoras de óleos voláteis. Parece haver afinidades químicas no gênero relacionadas à geografia, agrupando espécies com (i) cauranos e/ou labdanos, (ii) traquilobanos e (iii) alcalóides. Os ensaios farmacológicos freqüentemente vêm corroborando os usos tradicionais de espécies de Croton. Grande parte dos ensaios farmacológicos trata do clerodano trans-desidrocrotonina, envolvendo uma grande diversidade de efeitos, incluindo hipolipidêmico, hipoglicêmico, antiestrogênico e anticâncer. Efeitos citotóxicos também vêm sendo observados em ensaios com alcalóides (taspina) e com diterpenóides secocaurenos, labdanos e cembranóides. Vários outros efeitos de substâncias de Croton têm sido relatados, incluindo anti-hipertensivos, antiinflamatórios, antimaláricos, antimicrobianos, antiespasmódicos, antiulcerogênicos, antivirais e mio-relaxantes.Croton is a genus of Euphorbiaceae comprising around 1,300 species, widespread in tropical regions of the Old and New Worlds. Several species have a long role in the traditional use of medicinal plants in Africa, Asia and South America. Popular uses include treatment of cancer, constipation, diabetes, digestive problems, dysentery, external wounds, fever, hypercholesterolemia, hypertension, inflammation, intestinal worms, malaria, pain, ulcers and weight-loss. Several species of Croton have a red sap, in some species containing proanthocyanidins and/or alkaloids. The latter may be taspine or some of several benzylisoquinoline-like compounds. Diterpenes are very common in Croton, corresponding to clerodanes, cembranoid, halimanes, kauranes, labdanes, phorbol esters, trachylobanes and sarcopetalanes. Some species are aromatic due to the possession of volatile oils. Representatives of new classes of compounds (phenylbutanoids, glutarimide alkaloids, sarcopetalane diterpen...

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Section: Diterpenesmentioning

confidence: 99%

Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae)

Salatino¹,

Salatino²,

Negri³

2007

J. Braz. Chem. Soc.

377

316

View full text Add to dashboard Cite

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“…The plant is also well reputed for the production of valuable secondary metabolites of alkaloids, terpenes and flavanoids in nature (Puebla et al, 2003;Martins et al, 2002). Croton can be propagated by various methods such as cuttings, grafting, by seeds and air layering.…”

Section: Introductionmentioning

confidence: 99%

Propagating crotons from leaves

Devi¹,

Shanthi²

2013

Afr. J. Agric. Res.

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The present investigation was conducted in the Department of Horticulture, Agricultural College and Research Institute, Madurai during the period of 2011 to 2012. The croton leaves were placed in water for observation. Within a month, it was observed that, roots appeared from the petiole region of the leaves. The root length varied from 1.5 to 4 cm. Further, secondary roots were also observed from primary roots after one month. The rooted leaves were then placed in coir pith media and watered regularly. There was no symptom of shoot formation from the leaves. Leaves remained green for few months without showing any sign of wilting or drying.

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“…Further phytochemical investigations concerning this plant have led us to the isolation of two new neo-clerodane diterpenoids: (12R)-12-hydroxycascarillone and 5␤-hydroxy-cis-dehydrocrotonin, as well as cis-dehydrocrotonin and trans-dehydrocrotonin (Puebla et al, 2003). In the present work we wished to assess the role of these neo-clerodane diterpenoids in the vasorelaxant response induced by Croton schiedeanus.…”

Section: Introductionmentioning

confidence: 99%