Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094

Wang, Qiang; Zhang, Yixuan; Wang, Mian; Tan, Yi; Hu, Xinxin; He, Hongwei; Xiao, Chunling; You, Xuefu; Wang, Yiguang; Gan, Maoluo

doi:10.1038/s41598-017-03769-8

Cited by 43 publications

(28 citation statements)

References 25 publications

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“…Several novel species of Streptomyces have been reported worldwide as potential natural sources for the discovery of naturally occurring antibiotics [ 11 – 13 ]. Actinobacteria have been extensively reported from different ecosystems such as soil, freshwater, marine and as endophytes from plants [ 14 , 15 ] and have been investigated for their potential contributions to the pharmaceutical industry by different researchers [ 16 – 22 ]. However, there has been a significant decline in the rate of discovery of novel actinobacteria in recent years [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Bioprospection of actinobacteria derived from freshwater sediments for their potential to produce antimicrobial compounds

et al. 2018

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BackgroundActinobacteria from freshwater habitats have been explored less than from other habitats in the search for compounds of pharmaceutical value. This study highlighted the abundance of actinobacteria from freshwater sediments of two rivers and one lake, and the isolates were studied for their ability to produce antimicrobial bioactive compounds.Results16S rRNA gene sequencing led to the identification of 84 actinobacterial isolates separated into a common genus (Streptomyces) and eight rare genera (Nocardiopsis, Saccharopolyspora, Rhodococcus, Prauserella, Amycolatopsis, Promicromonospora, Kocuria and Micrococcus). All strains that showed significant inhibition potentials were found against Gram-positive, Gram-negative and yeast pathogens. Further, three biosynthetic genes, polyketide synthases type II (PKS II), nonribosomal peptide synthetases (NRPS) and aminodeoxyisochorismate synthase (phzE), were detected in 38, 71 and 29% of the strains, respectively. Six isolates based on their antimicrobial potentials were selected for the detection and quantification of standard antibiotics using ultra performance liquid chromatography (UPLC–ESI–MS/MS) and volatile organic compounds (VOCs) using gas chromatography mass spectrometry (GC/MS). Four antibiotics (fluconazole, trimethoprim, ketoconazole and rifampicin) and 35 VOCs were quantified and determined from the methanolic crude extract of six selected Streptomyces strains.ConclusionInfectious diseases still remain one of the leading causes of death globally and bacterial infections caused millions of deaths annually. Culturable actinobacteria associated with freshwater lake and river sediments has the prospects for the production of bioactive secondary metabolites.Electronic supplementary materialThe online version of this article (10.1186/s12934-018-0912-0) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Bioprospection of actinobacteria derived from freshwater sediments for their potential to produce antimicrobial compounds

et al. 2018

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“…These red pigments have a wide range of biological activities including anticancer properties [ 70 ]. Compounds 5–8 (elloxazinones A and B, exfoliazone, and carboxyexfoliazone) isolated from the EG25 strain contain the phenoxazinone scaffold, which have different pharmaceutical activities such as antimicrobial, antiviral, and anticancer [ 32 , 71 , 72 ]. As per literature, phenoxazinones are a group of secondary metabolites containing tricyclic rings heterocyclised by oxygen and nitrogen atoms [ 73 ].…”

Section: Discussionmentioning

confidence: 99%

Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP

Elmallah

Cogo

Constantinescu

et al. 2020

Cells

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Resistance of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis represents the major hurdle to the clinical use of TRAIL or its derivatives. The discovery and development of lead compounds able to sensitize tumor cells to TRAIL-induced cell death is thus likely to overcome this limitation. We recently reported that marine actinomycetes’ crude extracts could restore TRAIL sensitivity of the MDA-MB-231 resistant triple negative breast cancer cell line. We demonstrate in this study, that purified secondary metabolites originating from distinct marine actinomycetes (sharkquinone (1), resistomycin (2), undecylprodigiosin (3), butylcyclopentylprodigiosin (4), elloxizanone A (5) and B (6), carboxyexfoliazone (7), and exfoliazone (8)), alone, and in a concentration-dependent manner, induce killing in both MDA-MB-231 and HCT116 cell lines. Combined with TRAIL, these compounds displayed additive to synergistic apoptotic activity in the Jurkat, HCT116 and MDA-MB-231 cell lines. Mechanistically, these secondary metabolites induced and enhanced procaspase-10, -8, -9 and -3 activation leading to an increase in PARP and lamin A/C cleavage. Apoptosis induced by these compounds was blocked by the pan-caspase inhibitor QvD, but not by a deficiency in caspase-8, FADD or TRAIL agonist receptors. Activation of the intrinsic pathway, on the other hand, is likely to explain both their ability to trigger cell death and to restore sensitivity to TRAIL, as it was evidenced that these compounds could induce the downregulation of XIAP and survivin. Our data further highlight that compounds derived from marine sources may lead to novel anti-cancer drug discovery.

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“…Two new chromodepsipeptides, neo-actinomycin A ( 57 ) ( Figure 6 ) and neo-actinomycin B ( 58 ) were isolated from a marine-derived Streptomyces sp. IMB094 [ 92 ]. They showed strong cytotoxic effect on human colorectal carcinoma cell line HCT116 and human lung carcinoma cell line A549.…”

Section: Natural Productsmentioning

confidence: 99%

From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria

et al. 2020

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Oceans cover seventy percent of the planet’s surface and besides being an immense reservoir of biological life, they serve as vital sources for human sustenance, tourism, transport and commerce. Yet, it is estimated by the National Oceanic and Atmospheric Administration (NOAA) that eighty percent of the oceans remain unexplored. The untapped biological resources present in oceans may be fundamental in solving several of the world’s public health crises of the 21st century, which span from the rise of antibiotic resistance in bacteria, pathogenic fungi and parasites, to the rise of cancer incidence and viral infection outbreaks. In this review, health risks as well as how marine bacterial derived natural products may be tools to fight them will be discussed. Moreover, an overview will be made of the research pipeline of novel molecules, from identification of bioactive bacterial crude extracts to the isolation and chemical characterization of the molecules within the framework of the One Health approach. This review highlights information that has been published since 2014, showing the current relevance of marine bacteria for the discovery of novel natural products.

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Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094

Cited by 43 publications

References 25 publications

Bioprospection of actinobacteria derived from freshwater sediments for their potential to produce antimicrobial compounds

Bioprospection of actinobacteria derived from freshwater sediments for their potential to produce antimicrobial compounds

Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP

From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria

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