Nematotoxic activity of essential oils from Monarda species

Laquale, Sebastiano; Avato, Pinarosa; Argentieri, Maria Pia; Bellardi, Maria Grazia; D’Addabbo, T.

doi:10.1007/s10340-018-0957-1

Cited by 37 publications

(40 citation statements)

References 32 publications

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“…Two other studies published in 2017 reported the EO composition from this plant species cultivated in central Italy: the EO from the flowering aerial parts pointed to thymol (59.3%) and p-cymene (10.3%) as major compounds [116], while the second work evidenced thymol 62% [43]. Other Monarda species, always cultivated in Italy, were very rich in monoterpenes, but with o-cymene (13.42), γ-terpinene (22.15), and carvacrol (13.80%) as the main constituents, and thymol with a lesser amount (5.87%) [42]. The chemical characterisation of the EO from Nepeta can be traced back to 1967 when Regnier [117] studied three species and each one showed a different main compound: nepetalactone in N. cataria L. (77%), epi nepetalactone in N. mussini Spreng.…”

Section: Essential Oilsmentioning

confidence: 91%

Bioactive Compounds and Aroma Profile of Some Lamiaceae Edible Flowers

Marchioni

Najar

Ruffoni

et al. 2020

Plants

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Edible flowers are consumed for their appearance, colours, nutritional and healthy properties, but the use is limited by the actual number of the species. Seven edible flowers of the Lamiaceae family (Ocimeae and Mentheae tribes) were investigated: Monarda didyma ‘Fireball’, Nepeta × faassenii ‘Six Hills Giant’, Ocimum basilicum ‘Blue Spice’, O. basilicum ‘Cinnamon’, Ocimum × citriodorum, Salvia discolor, and Salvia microphylla ‘Hot Lips’. Total soluble sugars, proteins, polyphenols, carotenoids, ascorbic acid and antioxidant activity were detected. The species of the Mentheae tribe contained higher sugar content than Ocimeae flowers, the opposite with regard to protein content. Ocimeae tribe flowers showed high polyphenols and carotenoids content. The Ocimeae tribe together with two specie of the Mentheae tribe showed an aroma profile dominated by sesquiterpene hydrocarbons (58.0% in S. discolor to 77.9% in Ocimum × citriodorum). Oxygenated monoterpenes prevailed in Nepeta and Monarda, also present in the essential oil of this latter species (84.5%). By contrast, Nepeta and S. discolor evidenced non-terpenes as the principal class (41.2% and 77.5%, respectively), while the oxygenated sesquiterpene was the main one in S. microphylla. The two varieties of Ocimum spp. showed oxygenated monoterpenes as the main class of volatiles.

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Section: Essential Oilsmentioning

confidence: 91%

Bioactive Compounds and Aroma Profile of Some Lamiaceae Edible Flowers

Marchioni

Najar

Ruffoni

et al. 2020

Plants

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“…Previously studied species of Monarda had essential oils almost exclusively comprised of oxygenated monoterpenes, with thymol and carvacrol as the main constituents (Table 1) [8,11]. M. didyma grown in Canada had thymol, γ-terpinene, carvacrol, and β-myrcene as the main constituents, while Canadian M. fistulosa essential oil contained geraniol, geranial, geranyl formate, and p-cymene [13].…”

Section: Essential Oil Compositionmentioning

confidence: 99%

“…Essential oils of Monarda species have been reported to be rich in oxygenated monoterpenes, leading to differentiation into the following chemotypes: thymol, carvacrol, borneol, and geraniol [ 10 ]. A literature survey regarding biological activities of the Monarda species essential oils and their major compounds, based on references [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], is summarized in Table 1 .…”

Section: Introductionmentioning

confidence: 99%

Essential Oils from Monarda fistulosa: Chemical Composition and Activation of Transient Receptor Potential A1 (TRPA1) Channels

et al. 2020

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Little is known about the pharmacological activity of Monarda fistulosa L. essential oils. To address this issue, we isolated essential oils from the flowers and leaves of M. fistulosa and analyzed their chemical composition. We also analyzed the pharmacological effects of M. fistulosa essential oils on transient receptor potential (TRP) channel activity, as these channels are known targets of various essential oil constituents. Flower (MEOFl) and leaf (MEOLv) essential oils were comprised mainly of monoterpenes (43.1% and 21.1%) and oxygenated monoterpenes (54.8% and 77.7%), respectively, with a high abundance of monoterpene hydrocarbons, including p-cymene, γ-terpinene, α-terpinene, and α-thujene. Major oxygenated monoterpenes of MEOFl and MEOLv included carvacrol and thymol. Both MEOFl and MEOLv stimulated a transient increase in intracellular free Ca2+ concentration ([Ca2+]i) in TRPA1 but not in TRPV1 or TRPV4-transfected cells, with MEOLv being much more effective than MEOFl. Furthermore, the pure monoterpenes carvacrol, thymol, and β-myrcene activated TRPA1 but not the TRPV1 or TRPV4 channels, suggesting that these compounds represented the TRPA1-activating components of M. fistulosa essential oils. The transient increase in [Ca2+]i induced by MEOFl/MEOLv, carvacrol, β-myrcene, and thymol in TRPA1-transfected cells was blocked by a selective TRPA1 antagonist, HC-030031. Although carvacrol and thymol have been reported previously to activate the TRPA1 channels, this is the first report to show that β-myrcene is also a TRPA1 channel agonist. Finally, molecular modeling studies showed a substantial similarity between the docking poses of carvacrol, thymol, and β-myrcene in the binding site of human TRPA1. Thus, our results provide a cellular and molecular basis to explain at least part of the therapeutic properties of these essential oils, laying the foundation for prospective pharmacological studies involving TRP ion channels.

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“…Presence of a variety of nematicidal phytochemicals in many botanical families has increasingly focused the attention of scientists and farmers to plant-derived nematicidal products [2,3]. Previous studies of our research group documented a strong activity on phytoparasitic nematodes for chemical constituents of extracts from Asteraceae and Brassicaceae plants, such as phenolics and glucosinolates [4,5], as well as for the essential oils from many aromatic and medicinal plants [6,7].…”

Section: Introductionmentioning

confidence: 99%

Activity of Saponins from Medicago Species against Phytoparasitic Nematodes

D’Addabbo

Argentieri

Żuchowski

et al. 2020

Plants

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Content of bioactive saponins of Medicago species suggests that they may also exert, as previously demonstrated on M. sativa, nematicidal properties exploitable for the formulation of new products for sustainable phytoparasitic nematode management. This study was addressed to highlight the bioactivity of saponins from five different Medicago species still poorly known for their biological efficacy, i.e., M. heyniana, M. hybrida, M. lupulina, M. murex and M. truncatula, against the plant parasitic nematodes Meloidogyne incognita, Xiphinema index and Globodera rostochiensis. The bioactivity of the extracts from the five Medicago species was assessed by in vitro assays on the juveniles (J2) and eggs of M. incognita and G. rostochiensis and the adult females of X. index. The suppressiveness to M. incognita of soil treatments with the Medicago plant biomasses was also investigated in a tomato experiment. The nematicidal activity of the five Medicago species was reported and discussed in relation to their phytochemical profile.

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Nematotoxic activity of essential oils from Monarda species

Cited by 37 publications

References 32 publications

Bioactive Compounds and Aroma Profile of Some Lamiaceae Edible Flowers

Bioactive Compounds and Aroma Profile of Some Lamiaceae Edible Flowers

Essential Oils from Monarda fistulosa: Chemical Composition and Activation of Transient Receptor Potential A1 (TRPA1) Channels

Activity of Saponins from Medicago Species against Phytoparasitic Nematodes

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