Physiology and Biochemistry of Sterols 1992
DOI: 10.1201/9781439821831.ch9
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Nematode Sterol Biochemistry

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Cited by 6 publications
(10 citation statements)
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“…2A). Consistent with previous reports (21), cholesterol fed to the nematode generated cholesterol (cholest-5-enol) [1], 7-dehydrocholesterol (cholesta-5,7-dienol) [2], lathosterol (cholest-7-enol) [12], lophenol [17], and  8 (14) lophenol [4-methyl cholest-8(14)-enol] [18]. However, quite surprisingly, the D 6 -cholesterol supplement generated a disrupted sterol composition that was presumably due to a kinetic isotope effect on an intermediate enzyme that led to marked depletion in lathosterol and C4-methyl sterol metabolites ( Fig.…”
Section: Discovery Of Coordinately Branching Pathways In C Elegans Csupporting
confidence: 94%
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“…2A). Consistent with previous reports (21), cholesterol fed to the nematode generated cholesterol (cholest-5-enol) [1], 7-dehydrocholesterol (cholesta-5,7-dienol) [2], lathosterol (cholest-7-enol) [12], lophenol [17], and  8 (14) lophenol [4-methyl cholest-8(14)-enol] [18]. However, quite surprisingly, the D 6 -cholesterol supplement generated a disrupted sterol composition that was presumably due to a kinetic isotope effect on an intermediate enzyme that led to marked depletion in lathosterol and C4-methyl sterol metabolites ( Fig.…”
Section: Discovery Of Coordinately Branching Pathways In C Elegans Csupporting
confidence: 94%
“…14). Careful inspection of the GC trace showed, as reported previously (21), a trace metabolite eluting at RRTc 1.27 with M + 414, and its mass spectrum was consistent with the previously identified 24-methyl lophanol. However, within our limits of detection there was no GC/MS evidence for 3-oxo sterols.…”
Section: Demonstration For An Ancient C4-sterol Metabolism Pathway Casupporting
confidence: 84%
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“…More directly, both sterol starvation and mutations in a megalinrelated protein LRP-1, which presumably mediates sterol endocytosis by hyp7 hypodermis, have been shown to prevent the shedding and degradation of the old cuticle at all C. elegans moults (Yochem et al 1999). Whether ecdysteroids are required for nematode moulting is not clear, as their synthesis from cholesterol has not been demonstrated (Chitwood 1992).…”
Section: Nhr-25 As a Core Regulator Of Moultingmentioning
confidence: 99%