2021
DOI: 10.1101/2021.07.23.453445
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Nematode Small RNA Pathways in the Absence of piRNAs

Abstract: Small RNA pathways play diverse regulatory roles in the nematode C. elegans. However, our understanding of small RNA pathways, their conservation, and their roles in other nematodes is limited. Here, we analyzed small RNA pathways in the parasitic nematode Ascaris. Ascaris has ten Argonautes with five worm-specific Argonautes (WAGOs) that are associated with secondary 5'-triphosphate small RNAs (22-24G-RNAs). These Ascaris WAGOs and their small RNAs target repetitive sequences (WAGO-1, WAGO-2, WAGO-3, and NRDE… Show more

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Cited by 3 publications
(1 citation statement)
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“…sRNAs similar to secondary 22Gs in C. elegans have also been reported in other nematodes. For example, the clade I-III nematodes produce 22G sRNAs processed by RdRPs, which mainly target TEs in the absence of piRNAs 544 . RdRP orthologues related to the processing of 22G siRNAs in C. elegans are also present in Strongyloides 7 , indicating that the RdRP pathway is active.…”
Section: Discussionmentioning
confidence: 99%
“…sRNAs similar to secondary 22Gs in C. elegans have also been reported in other nematodes. For example, the clade I-III nematodes produce 22G sRNAs processed by RdRPs, which mainly target TEs in the absence of piRNAs 544 . RdRP orthologues related to the processing of 22G siRNAs in C. elegans are also present in Strongyloides 7 , indicating that the RdRP pathway is active.…”
Section: Discussionmentioning
confidence: 99%