Nematode-associated Intramural Alimentary Nodules in Pumas are Histologically Similar to Gastrointestinal Eosinophilic Sclerosing Fibroplasia of Domestic Cats

Eckstrand, Chrissy; Barr, Bradd C.; Woods, Leslie W.; Spangler, Taylor; Murphy, Brian G

doi:10.1016/j.jcpa.2012.07.003

Cited by 16 publications

(25 citation statements)

References 9 publications

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“…Thus, FGESF might represent a unique stereotypic pattern of inflammation and repair that occurs in some felids in response to tissue injury. This damage might potentially be caused by different aetiological factors including bacteria, fungi, parasites and/or trauma such as foreign body penetration (Eckstrand et al, 2013) and the present case provides evidence for a role for fungal infection in some circumstances. …”

Section: Kidneys Displayed Moderate Interstitial Nephritis and Cysticsupporting

confidence: 51%

“…Recently, lesions resembling FGESF have been described in pumas (Puma conclor), where the lesions were associated with the presence of intestinal nematodes (Cyclospirura sp. ; Eckstrand et al, 2013). Radiography and ultrasonography indicated gastric distention, a thickened duodenal wall and enlarged mesenteric lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

“…However, bacterial agents are not observed in approximately 50% of cases of FGESF, and antibiotic treatments are apparently not effective (Craig et al, 2009;Suzuki et al, 2013). Moreover, parasites and phycomycetes typically elicit an eosinophilic reaction, which is one of the hallmarks of this condition (Grooters, 2003;Craig et al, 2009;Eckstrand et al, 2013). Interestingly, the most common location of gastrointestinal lesions in cases of oomycosis are the gastric outflow area (including proximal duodenum) and the ileocolic junction and the same areas are most often the site of FGESF (Grooters, 2003).…”

Section: Kidneys Displayed Moderate Interstitial Nephritis and Cysticmentioning

confidence: 99%

See 2 more Smart Citations

A Case of Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia Associated with Phycomycetes

Grau‐Roma

Galindo-Cardiel

Isidoro-Ayza

et al. 2014

Journal of Comparative Pathology

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Section: Kidneys Displayed Moderate Interstitial Nephritis and Cysticsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Kidneys Displayed Moderate Interstitial Nephritis and Cysticmentioning

confidence: 99%

See 1 more Smart Citation

A Case of Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia Associated with Phycomycetes

Grau‐Roma

Galindo-Cardiel

Isidoro-Ayza

et al. 2014

Journal of Comparative Pathology

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“…Owing to its unique histologic appearance, Eckstrand et al proposed the term verminous alimentary sclerosing fibroplasia (VASF) for gastrointestinal cylicospiruriasis. 1 Unlike lupi, Cylicospirura species nodules have not been shown to progress to neoplasms. In this particular case an adult neutered feral domestic shorthair feline of unknown age was humanely euthanized owing to the acute and progressive neurologic signs ultimately attributed to ethylene glycol toxicity, with gastric cylicospiruriasis representing an incidental finding.…”

Section: Introductionmentioning

confidence: 99%

First report of Cylicospirura felineus in a feral domestic shorthair cat in North America

Crossland

Hanks

Ferguson

et al. 2015

Journal of Feline Medicine and Surgery Open Reports

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Case summaryA feral domestic shorthair cat was euthanized owing to acute onset and progression of neurological signs attributed to ethylene glycol toxicity. At post-mortem examination two nodules were identified within the fundus of the stomach. Examination of the gastric nodules revealed an intact mucosal surface, each with multiple red slender nematodes extending through an individual central pore. Histopathological evaluation of the nodules highlighted unique reactive fibroplasia, mimicking feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF), encasing numerous nematodes with females possessing gravid uteri containing abundant larvated eggs. The latter findings were highly suggestive of the Cylicospirura genus, further supported by an en face evaluation of the buccal cavity, highlighting a distinctive trifid tooth appearance. Together, these findings are consistent with Cylicospirura felineus. PCR for the COX-1 gene was unsuccessful on formalin-fixed specimens, attributed to nucleic acid and protein crosslinking.Relevance and novel informationThis represents the first documented case of Cylicospirura species in a feral domestic shorthair cat in North America. This particular cat lived in the highly urban environment of New Orleans, Louisiana. Identification of this case demonstrates the potential for feral cats to serve as reservoir hosts and ultimately support transmission of Cylicospirura species into domesticated cat populations. Gastric cylicospiruriasis may present clinically as a firm abdominal mass, potentially with a history of chronic vomiting. The latter emphasizes the importance of differentiating this condition from a neoplastic process such as alimentary lymphoma and adenocarcinoma. Histologically, the unique thick anastomosing collagenous cords encasing nematodes represent a stereotypical response observed in a broad array of gastrointestinal inflammation in felines, including intralesional bacteria, fungal hyphae, foreign bodies and, in this case, gastric nematodes that closely resemble FGESF. Additionally, these unique histological lesions have previously been misinterpreted as neoplastic conditions, including sclerosing mast cell tumor and extraosseous osteosarcoma.

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“…This disease has been reported in cats and pumas ( Puma concolor ) [2,3,4, 9]. The etiology of this disease is the infection (bacteria, fungi and nematodes), foreign body or unknown [2,3,4, 7, 9].…”

mentioning

confidence: 99%

Jejunal fibroplasia in a rat

Kawasako¹,

Kanno²,

Hamamura³

2017

The Journal of Veterinary Medical Science

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A jejunal nodular mass was identified in an aging rat. Histologically, the boundaries between the lesion and surrounding normal tissue as well as between the inner circular muscle and outer longitudinal muscle were indistinct. The lesion consisted of abundant eosinophilic matrix and cells with a large round to oval nucleus and indistinct cytoplasm. There was no characteristic proliferating pattern, nuclear polymorphism and a low mitotic figure count. Masson’s trichrome stain revealed that the intestinal smooth muscles were replaced by the abundant collagen fiber. Immunohistochemistry revealed that the cells with a large round to oval nucleus were labeled with anti-vimentin antibody and not with anti-α smooth muscle actin antibody, suggesting that these cells were fibroblasts. The mass was diagnosed as jejunal fibroplasia.

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Nematode-associated Intramural Alimentary Nodules in Pumas are Histologically Similar to Gastrointestinal Eosinophilic Sclerosing Fibroplasia of Domestic Cats

Cited by 16 publications

References 9 publications

A Case of Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia Associated with Phycomycetes

A Case of Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia Associated with Phycomycetes

First report of Cylicospirura felineus in a feral domestic shorthair cat in North America

Jejunal fibroplasia in a rat

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