Nematocidal quassinoids and bicyclophosphorothionates: a possible common mode of action on the GABA receptor

Nematode cys-loop GABA receptors: biological function, pharmacology and sites of action for anthelmintics

“…These molecules appear to block GABA receptors in a similar fashion as PTX (Watanabe et al 2000;Kuriyama et al 2005). It was also shown that other noncompetitive GABA receptor antagonists (namely, variants of 3-isopropyl-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane 1-sulphides or 3-isopropyl-BPTs) were effective against Diplogastridae nematodes (Kuriyama et al 2005).…”

“…Other nematicidal drugs such as the quassinoids have been shown to be effective on nematodes of the Diplogastridae family (Watanabe et al 2000;Kuriyama et al 2005). These molecules appear to block GABA receptors in a similar fashion as PTX (Watanabe et al 2000;Kuriyama et al 2005).…”

Pesticides of Botanical Origin: a Promising Tool in Plant Protection

“…Quassinoids act against insects, nematodes and weeds (Koul, 2008;Powell et al, 1998;Leskinen et al, 1984;Chitwod, 2002;Lin et al, 1995). In nematodes quassinoids acts as noncompetitive antagonists of the ionotropic GABARs to stabilize the closed conformation of the channel, resulting in the inhibition of the action of GABA (Kuriyama et al, 2005). No data are currently available concerning quassinoids fate in the environment.…”

γ-Aminobutyric Acid Receptors: A Rationale for Developing Selective Insect Pest Control Chemicals

“…It is interesting to note that quassinoids (e.g., samaderine B) (Fig. 4), plant-derived nematocidal terpenoids, proved to have a possible structural overlap with bicyclophosphorothionates (Kuriyama et al 2005).…”