Nematicidal Activity of Fosthiazate Against Soybean Cyst Nematode <i>Heterodera glycines</i>

Wu, Haiyan; Luo, Ming; Zhang, Lu Yuan; Zhou, Xun Bo

doi:10.21307/jofnem-2019-021

Cited by 10 publications

(3 citation statements)

References 16 publications

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“…Finally S.marcescens recorded (8.51%, 10.35%, 13.7% and 15.26%) in nematode mortality after 24, 48, 72 and 96 hours, respectively. The current results are consistent with many studies (Woods, et al, 1999, Huang, et al, 2016, Wu, et al, 2019 that have proven the effectiveness of the pesticide, as it is described as a systemic phosphorous nematicide that affects the central nervous system of nematodes, with the distinction of eliminating all stages of nematodes. Nematodes represent a danger to the plant by affecting growth, as the infection leads to a delay in vegetative growth and the transfer of nutrients from the soil through the root system to the rest of the plant parts.…”

Section: Discussionsupporting

confidence: 90%

Management of root-knot nematode (Meloidogyne incognita) and improve defensive ability of cucumber plant using Serratia marcescens, Salicylic acid and Fosthiazate (melotherin®) through adaptive processes and antioxidant capacity

nofal

Attia²

2023

Menoufia Journal of Plant Protection

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Plant parasitic nematodes are dangerous pests that infect many agricultural crops including cucumber. A greenhouse experiment was conducted in the experimental farm of Botany and Microbiology Department, Faculty of Science, Al-Azhar University, to evaluate the efficicy of Salicylic acid and Fosthiazate (melotherin®) as abiotic elicitors and Serratia marcescens as biotic elicitor against root-knot nematode, Meloidogyne incognita infecting cucumber plants. The highest mortality percentages of M. incognita 2 nd juveniles invitro 96 hours after applying tested materrials were recorded with Fosthiazate (melotherin®) followed by salicylic acid and Serratia marcescens by 74.2%, 27.87% and 13.19 % respectively. Under greenhouse conditions, similar results were obtained, where Fosthiazate (melotherin®) was the most potent treatment in reducing nematode galls, egg masses, females, and developmental stages in infected cucumber roots by 86.15%, 93.89%, 67.81% and 73.22% respectively as well as decreased 2 nd juveniles in the soil by 79.48%, followed by Salicylic acid and Serratia marcescens respectively. Regarding to plant morphological and biochemical parameters, application of Serratia marcescens followed by salicylic acid showed significant improvements in cucumber vegetative growth and yield as well as photosynthetic pigments and antioxidant enzymes. It could be suggested that application of Fosthiazate (melotherin®), Serratia marcescens and Salicylic acid could be commercially used as safe, effective and cheap nematicides against root-knot nematodes.

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Section: Discussionsupporting

confidence: 90%

Management of root-knot nematode (Meloidogyne incognita) and improve defensive ability of cucumber plant using Serratia marcescens, Salicylic acid and Fosthiazate (melotherin®) through adaptive processes and antioxidant capacity

nofal

Attia²

2023

Menoufia Journal of Plant Protection

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“…Nematicides are an important management tool, but increasing attention to human and environmental safety has led to the cancellation of several agronomically effective nematicides (Wu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Dissipation and residue of fosthiazate in tomato and cherry tomato and a risk assessment of dietary intake

Lin

et al. 2021

Environ Sci Pollut Res

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In this study, the safety and risk of fosthiazate as a nematicide against root-knot nematode in tomato and cherry tomato were evaluated. The dissipation and residue of fosthiazate for 28 days in tomato and cherry tomato were determined and studied by HPLC after simple, rapid pre-treatment. The mean recovery was 83.79 ~ 94.18%, and the relative standard deviation was 3.97 ~ 7.40%. Results showed that the halflives of fosthiazate in tomato (4.81 ~ 5.37 days) were signi cantly lower than that in cherry tomato (5.25 5.73 days). At the pre-harvest interval (PHI) of 21 days, the residues of tomatoes and cherry tomatoes were 0.032 ~ 0.046 mg/kg, which were lower than the maximum residue level established in China. The potential risks of fosthiazate exposure through the dietary intake of tomatoes and cherry tomatoes to different populations were also studied. According to the results of dietary risk assessment, the residual levels of fosthiazate were within the acceptable range of long-term dietary risk in different populations in China within the sampling interval of 21 days after the application of pesticide. Our results show that fosthiazate as a nematicide in the eld control of root-knot nematode has high safety and low risk, and can provide a reference for the safe and reasonable use of fosthiazate as a nematicidein in the eld.

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“…However, most of them were eliminated gradually because of their environment and food safety risks . For example, methyl bromide was phased out in 2005, although some OP and carbamate nematicides, such as fosthiazate and oxamyl, still occupy a large part of the nematicide market. , These two classes of nematicides might be prohibited in the future as a result of their high toxicity. Avermectin has become the mainstream nematicide at present.…”

Section: Introductionmentioning

confidence: 99%

Bioisosterism and Scaffold Hopping in Modern Nematicide Research

Cao

Yang

Liu

et al. 2022

J. Agric. Food Chem.

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The application of agrochemicals is critical to global food safety. Nowadays, environmentally friendly green agrochemicals are the trend in field crop protection. The research and development of nematicides absorbed more attention as a typical representation of agrochemicals. This review describes the origin of recently commercialized nematicides, the application of bioisosterism and scaffold hopping in the discovery and optimization of agrochemicals, especially nematicides, and novel bioisosteric design strategies for the identification of fluensulfone analogues. Pesticide repurposing, high-throughput screening, computer-aided drug design, and incorporation of known pharmacophoric fragments have been the most successful approach for the discovery of new nematicides. As outlined, the strategies of bioisosteric replacements and scaffold hopping have been very successful approaches in the search for new nematicides for sustainable crop protection. In the exploration of novel fluensulfone analogues with nematicidal activity, bioisosteric replacement of sulfone by amide, chain extension by insertion of a methylene group, and reversal of the amide group have proven to be successful approaches and yielded new and highly active fluensulfone analogues. These attempts might result in compounds with an optimal balance of steric, hydrophobic, electronic, and hydrogen-bonding properties and contribute to deal with the complex problem during the research and development of new nematicides. Further ideas are also put forward to provide new approaches for the molecular design of nematicides.

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Nematicidal Activity of Fosthiazate Against Soybean Cyst Nematode Heterodera glycines

Cited by 10 publications

References 16 publications

Management of root-knot nematode (Meloidogyne incognita) and improve defensive ability of cucumber plant using Serratia marcescens, Salicylic acid and Fosthiazate (melotherin®) through adaptive processes and antioxidant capacity

Management of root-knot nematode (Meloidogyne incognita) and improve defensive ability of cucumber plant using Serratia marcescens, Salicylic acid and Fosthiazate (melotherin®) through adaptive processes and antioxidant capacity

Dissipation and residue of fosthiazate in tomato and cherry tomato and a risk assessment of dietary intake

Bioisosterism and Scaffold Hopping in Modern Nematicide Research

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