Nelumbo Nucifera leaf protects against UVB-induced wrinkle formation and loss of subcutaneous fat through suppression of MCP3, IL-6 and IL-8 expression

Park, Ki Moon; Yoo, Young Je; Ryu, Sujin; Lee, Seung Ho

doi:10.1016/j.jphotobiol.2016.04.006

Cited by 14 publications

(11 citation statements)

References 28 publications

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“…Recent study by Park et al revealed that topical administration of dichloromethyl extract of N. nucifera leaves attenuated ultraviolet-B (UVB)-mediated wrinkle formation and reduction of subcutaneous fat in vivo. In addition, the study reported that the treatment of the extract inhibited UVB-induced expression of IL-6, IL-8, and MCP3, which are known regulators in subcutaneous fat metabolism, in mouse skin fibroblasts, suggesting the potential therapeutic role for N. nucifera leaves against photoaging-related disorders (Park et al, 2016). Similarly, the long-term consumption of lotus seed tea obtained from roasted uncoated seeds of N. nucifera resulted in higher moisture content and thinner epidermis in the UVB-irradiated skin of rats than that of rats consumed with water only.…”

Section: Pharmacological Reportsmentioning

confidence: 98%

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

Sharma

Gautam

Adhikari³

et al. 2016

Phytotherapy Research

131

106

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Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword 'Nelumbo nucifera pharmacology' in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty-three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Pharmacological Reportsmentioning

confidence: 98%

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

Sharma

Gautam

Adhikari³

et al. 2016

Phytotherapy Research

131

106

View full text Add to dashboard Cite

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“…The ethanol extracts of the lotus seed epicarps at a concentration of 100 μg/mL (Qi & Zhou, ) and methanol extracts of the petals at 2 μg/mL (Velusami et al., ) can inhibit preadipocyte (3T3‐L1 cells) differentiation by 70% and 19%, respectively. Controversially, Park, Yoo, Ryu, and Lee () reported that dichloromethyl and n ‐hexane fractions of LL, extracted using 99% methanol, at 20 μg/mL stimulated adipocyte differentiation by 146.8% and 125.12%, respectively; whereas the water fractions attenuated the differentiation by 89.6%. This indicated that the extraction solvents have a great impact on adipocyte differentiation.…”

Section: Health‐promoting Activitiesmentioning

confidence: 99%

“…A reduced amount of subcutaneous (SC) fat, often detected in the elderly exposed to UV, is one of the many representative phenomena of the photo‐aging process (Lemieux, ). The dichloromethyl extract of LL effectively inhibited UVB‐induced wrinkle formation and prevented the reduction of SC fat by inhibiting UV‐induced expression of cytokines, which are the regulators of SC fat metabolism (Park et al., ).…”

Section: Health‐promoting Activitiesmentioning

confidence: 99%

Lotus Flavonoids and Phenolic Acids: Health Promotion and Safe Consumption Dosages

Limwachiranon

Huang

Shi

et al. 2018

Comp Rev Food Sci Food Safe

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Nelumbo nucifera Gaertn., also known as the sacred lotus, is extensively cultivated in Southeast Asia, primarily for food and as an herbal medicine. This article reviews studies published between 1995 and 2017, on flavonoid and phenolic acid profiles and contents of 154 different cultivars of lotus. So far, some 12 phenolic acids and 89 to 90 flavonoids (47 flavonols, 25 to 26 flavons, 8 flavan-3-ols, 4 flavanons, and 5 anthocyanins) have been isolated from different parts of the lotus plant, including its leaves (whole leaf, leaf pulp, leaf vein, and leaf stalk), seeds (seedpod, epicarp, coat, kernel, and embryo), and flowers (stamen, petal, pistil, and stalk), although not all of them have been quantified. Factors affecting flavonoids and phenolic acid profiles, including types of tissues and extracting factors, are discussed in this review, in order to maximize the application of the lotus and its polyphenols in the food industry. Health promotion activities, attributed to the presence of flavonoids and phenolic acids, are described along with toxicology studies, illustrating appropriate usage and safe consumption dosages of lotus extracts. This review also presents the controversies and discusses the research gaps that limit our ability to obtain a thorough understanding of the bioactivities of lotus extracts.

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“…As reported previously, proinflammatory cytokines, such as IL‐6, IL‐8, and IL‐1β, have a major influence on the proliferation or differentiation of adipocytes (Li et al, ; Ballak et al, ; Park et al, ). As IL‐1α robustly enhanced the expression of these cytokines, we speculated that the effect of IL‐1α was partially mediated by these cytokines.…”

Section: Resultsmentioning

confidence: 65%

IL‐1α inhibits proliferation and adipogenic differentiation of human adipose‐derived mesenchymal stem cells through NF‐κB‐ and ERK1/2‐mediated proinflammatory cytokines

Sun

Zou

Zuo

et al. 2018

Cell Biology International

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Dysfunctional adipogenesis such as subcutaneous lipoatrophy is closely related to insulin resistance and metabolic disorders. Although the expression or release of the cytokine interleukin-1α (IL-1α) is known to increase in adipose tissue in response to cell death, cell senescence, aging, or solar radiation, the regulatory role of IL-1α in adipogenesis has not been sufficiently investigated. To investigate the problem, we explored the effect of IL-1α on the proliferation and adipogenic differentiation of human adipose-derived mesenchymal stem cells (ADSCs) using cell counting, alamarBlue assay, oil red O staining, Western blot, among others. The results showed that IL-1α evidently inhibited the proliferation and adipogenic differentiation of ADSCs, which might be related with the activated nuclear factor-κB (NF-κB) and extracellular signal-regulated kinase (ERK) 1/2 pathways. Early-stage adipogenic differentiation was more sensitive to IL-1α than late-stage differentiation. After differentiation of ADSCs into mature adipocytes, adding of IL-1α had no obvious influence on the cellular morphology, including lipid droplet accumulation. IL-1α enhanced the expression of proinflammatory cytokines, such as IL-8, IL-6, CCL2 (C-C motif chemokine ligand 2), and IL-1β, when added into the adipogenic medium of ADSCs. Blocking IL-8 and IL-6 with neutralizing antibodies partially alleviated the inhibitory effect of IL-1α on the proliferation and adipogenic differentiation. The results suggest that IL-1α inhibits adipogenesis through activation of NF-κB and ERK1/2 pathways and subsequent upregulation of proinflammatory cytokines in ADSCs. IL-1α might play an important role in mediating lipoatrophy by regulation of ADSCs.

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Nelumbo Nucifera leaf protects against UVB-induced wrinkle formation and loss of subcutaneous fat through suppression of MCP3, IL-6 and IL-8 expression

Cited by 14 publications

References 28 publications

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

Lotus Flavonoids and Phenolic Acids: Health Promotion and Safe Consumption Dosages

IL‐1α inhibits proliferation and adipogenic differentiation of human adipose‐derived mesenchymal stem cells through NF‐κB‐ and ERK1/2‐mediated proinflammatory cytokines

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