Neither Neoplasia Nor Tuberculosis, but Francisella

Abstract

Tularaemia is an emerging anthropozoonosis transmitted by contact with infected animals and through arthropod bites, inhalation, or ingestion. We describe a pulmonary nodule suggesting cancer in a 70-year-old man. Histological analysis excluded neoplasia, and bacteriological culture excluded tuberculosis. Serological testing and PCR Francisella were positive for this hunter patient, then treated by ciprofloxacin with a favourable outcome.

Tularemia pulmonar: la gran simuladora

“…Más recientemente, Mambie et al 8 describen un caso de masa pulmonar con adenopatía satélite y captación patológica en PET-TAC. Se llegó al diagnóstico tras exéresis quirúrgica.…”

Mechanisms Affecting the Acquisition, Persistence and Transmission of Francisella tularensis in Ticks

“…At least three different types of hemocytes exist in D. variabilis , namely plasmatocytes, type-1 granulocytes, and type-2 granulocytes, which form a multilayered capsule around foreign objects [ 119 ]. While studies have not been performed to examine aggregation or encapsulation of F. tularensis in D. variabilis or A. americanum , it is interesting to note that descriptions of tick hemocyte encapsulation of bacteria, including formation of a necrotic core in the center of these nodule-like masses, resemble descriptions of granuloma-like masses in F. tularensis -infected animals and humans [ 120 , 121 , 122 ]. D. variabilis hemocytes also have been shown to directly phagocytose and eliminate B. burgdorferi from infected ticks in <24 h [ 123 ].…”