Neisseria

Mietzner, Timothy A.; Morse, Stephen

doi:10.1002/9780470688618.taw0048

Cited by 2 publications

(2 citation statements)

References 291 publications

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“…These bacteria were previously reported to be commonly found in the oral and nasal cavities of healthy humans ( 30 – 35 , 50 , 51 ). Previous reports have shown that Neisseria subflava, Neisseria perflava , and Veillonella tobetsuensis are the early colonizers ( 32 , 33 , 35 ) of the oral cavity and specifically Veillonella tobetsuensis coaggregates with Streptococcus sp. ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

“…In our study, microbiome composition in the Delta- and Omicron-infected patients clearly showed distinct clusters along the PCA axes. Furthermore, both univariate and multivariate analyses showed that the URT of Omicron-infected patients is mostly predominated by healthy control-associated bacteria like Streptococcus symci ( 30 ) , Prevotella melaninogenica ( 20 ), Neisseria perflava ( 32 , 33 ) , Veillonella tobetsuensis ( 35 ) , Veillonella nakazawae ( 34 ) along with non-commensal Pseudomonas aeruginosa ( 39 ), and potential pathogen Staphylococcus caprae ( 60 ), whereas those of Delta-infected patients showed a predominance of non-commensals like Enterobacter mori ( 61 ), Acinetobacter baumannii ( 62 ), Enterobacter quasihormaechei ( 63 ), Klebsiella pneumoniae ( 64 ), and Klebsiella quasipneumoniae ( 65 ).…”

Section: Discussionmentioning

confidence: 99%

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Upper respiratory tract microbiome profiles in SARS-CoV-2 Delta and Omicron infected patients exhibit variant specific patterns and robust prediction of disease groups

Nath,

Sarkar,

Maddheshiya

et al. 2023

Microbiol Spectr

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The pandemic caused by the SARS-CoV-2 virus is the reason for many deaths globally. It is hypothesized that the upper respiratory tract (URT) microbiome shares similarities with lung microbiota and can modulate host immune responses to the virus. During the pandemic, several SARS-CoV-2 variants have emerged with different clinical outcomes and immune dysfunction, yet their association with changes in the URT microbiome has not been identified, which may provide an assessment of lung health in the presence of those variants with differential disease outcomes. In this study, we sequenced V3–V4 region of the 16S rRNA gene from the URT microbiome of healthy controls (HC), Delta- and Omicron-infected patients from Eastern India, which showed higher inter-individual diversity (β) and lower intra-individual diversity (α) in COVID-19 patients compared to healthy controls. Healthy control microbiome showed enrichment of commensals like Streptococcus symci , Prevotella melaninogenica , Neisseria perflava , Veillonella tobetsuensis, Veillonella nakazawae, Haemophilus parainfluenzae, Fusobacterium pseudoperiodonticum , and Bifidobacterium longum compared to COVID-19 samples. Ct value of patients significantly positively correlated with Streptococcus symci and Streptococcus toyakuensis indicating a possible inverse relation with viral load. We also observed few bacterial taxa like Staphylococcus caprae, Pseudomonas aeruginosa , Vibrio tritonious , and Rothia mucilaginosa are discriminating Omicron from Delta which is, in turn, enriched mostly with Enterobacter mori , Acinetobacter baumannii, and Klebsiella pneumoniae . Further investigation showed nine control-associated bacteria had higher to lower trends among three groups viz., Control > Omicron > Delta. These bacteria also contributed to the successful prediction of disease groups with high accuracy (90% ± 0.5%) by random forest analysis. IMPORTANCE The role of the upper respiratory tract (URT) microbiome in predicting lung health has been documented in several studies. The dysbiosis in COVID patients has been associated with disease outcomes by modulating the host immune system. However, although it has been known that different SARS-CoV-2 variants manifest distinct transmissibility and mortality rates in human populations, their effect on the composition and diversity of the URT microbiome has not been studied to date. Unlike the older variant (Delta), the newer variant (Omicron) have become more transmissible with lesser mortality and the symptoms have also changed significantly. Hence, in the present study, we have investigated the change in the URT microbiome associated with Delta and Omicron variants and identified variant-specific signatures that will be useful in the assessment of lung health and can be utilized for nasal probiotic therapy in the future.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Upper respiratory tract microbiome profiles in SARS-CoV-2 Delta and Omicron infected patients exhibit variant specific patterns and robust prediction of disease groups

Nath,

Sarkar,

Maddheshiya

et al. 2023

Microbiol Spectr

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Disease-Associated Neisseria meningitidis Isolates Inhibit Wound Repair in Respiratory Epithelial Cells in a Type IV Pilus-Independent Manner

Ren

MacKichan

2014

Infect Immun

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c Neisseria meningitidis is the causative agent of meningococcal disease. Onset of meningococcal disease can be extremely rapid and can kill within a matter of hours. However, although a much-feared pathogen, Neisseria meningitidis is frequently found in the nasopharyngeal mucosae of healthy carriers. The bacterial factors that distinguish disease-from carriage-associated meningococci are incompletely understood. Evidence suggesting that disruptions to the nasopharynx may increase the risk of acquiring meningococcal disease led us to evaluate the ability of disease-and carriage-associated meningococcal isolates to inhibit cell migration, using an in vitro assay for wound repair. We found that disease-associated isolates in our collection inhibited wound closure, while carriage-associated isolates were more variable, with many isolates not inhibiting wound repair at all. For isolates selected for further study, we found that actin morphology, such as presence of lamellipodia, correlated with cell migration. We demonstrated that multiple meningococcal virulence factors, including the type IV pili, are dispensable for inhibition of wound repair. Inhibition of wound repair was also shown to be an active process, i.e., requiring live bacteria undergoing active protein synthesis.

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Neisseria

Cited by 2 publications

References 291 publications

Upper respiratory tract microbiome profiles in SARS-CoV-2 Delta and Omicron infected patients exhibit variant specific patterns and robust prediction of disease groups

Upper respiratory tract microbiome profiles in SARS-CoV-2 Delta and Omicron infected patients exhibit variant specific patterns and robust prediction of disease groups

Disease-Associated Neisseria meningitidis Isolates Inhibit Wound Repair in Respiratory Epithelial Cells in a Type IV Pilus-Independent Manner

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