Neisseria meningitidis pneumonia with bacteremia without meningitis: An atypical presentation

Mahmoud, Fatma; Harhara, Thana

doi:10.1016/j.idcr.2020.e00897

Cited by 8 publications

(17 citation statements)

References 6 publications

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“…However in humans, Neisseria meningitidis has been reported to cause bacteremia (Mahmoud & Harhara, 2020). We suspect that Neisseria species in the fox population may also be contributing to secondary infection alongside S. pseudintermedius.…”

Section: Discussionmentioning

confidence: 92%

Ear mite infection restructures otic microbial networks in conservation–reliant Santa Catalina Island foxes (Urocyon littoralis catalinae)

Hamblen

Brenner

et al. 2022

Molecular Ecology

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Ceruminous gland tumours are highly prevalent in the ear canals of Santa Catalina Island foxes (Urocyon littoralis catalinae). Previous work suggests that tumours may result from a combination of ectoparasites, disruption of the host‐associated microbiome, and host immunopathology. More specifically, ear mite infection has been associated with broad‐scale microbial dysbiosis marked by secondary bacterial infection with the opportunistic pathogen Staphylococcus pseudintermedius. Together, ear mites and S. pseudintermedius probably sustain chronic inflammation and promote conditions suitable for tumour development. In the present study, we expanded upon this framework by constructing otic microbial community networks for mite‐infected and uninfected foxes sampled in 2017–2019. Across sampling years, we observed consistent signatures of microbial dysbiosis in mite‐infected ear canals, including reduced microbial diversity and shifted abundance towards S. pseudintermedius. Network analysis further revealed that mite infection disrupts overall community structure. In mite‐infected networks, interaction strengths between taxa were generally weaker, and numerous subnetworks disappeared altogether. We also found that two strains of S. pseudintermedius connected to the main network, suggesting that multistrain biofilm formation may be occurring. In contrast, S. pseudintermedius is peripheral in the uninfected network, with its only connections including a second strain of S. pseudintermedius and the possible competitor Acinetobacter rhizosphaerae. Finally, the lineup of potential keystone taxa shifted across disease states. Fusobacteria spp., a carcinogenesis‐promoting microbe, assumed a keystone role in the mite‐infected community. Considered together, these findings provide insights into how mite infection may destabilize the microbiome and ultimately contribute to tumour development in this island endemic species.

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Section: Discussionmentioning

confidence: 92%

Ear mite infection restructures otic microbial networks in conservation–reliant Santa Catalina Island foxes (Urocyon littoralis catalinae)

Hamblen

Brenner

et al. 2022

Molecular Ecology

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“…At least 13 serogroups of meningococci have been identified. 5 , 10 Serogroups A, B, C, X, Y, and W-135 are associated with disease in humans and serogroups B, Y, and W-135 are most associated with pneumonia. 4 , 11 , 12 Diagnosis is typically made by blood culture positive for NM in the presence of community-acquired pneumonia.…”

Section: Discussionmentioning

confidence: 99%

“… 4 The incidence of MP remains unclear but is estimated to be 5% to 15% in patients with invasive meningococcal disease. 5 …”

Section: Introductionmentioning

confidence: 99%

“…Only 344 MP cases have been documented worldwide between 1906 and 2015. 4 , 5 , 7 In the United States, only 3 cases of MP have been reported between 1998 and 2018. 2 To the best of our knowledge, this is the first reported case of possible concurrent NM and SARS-CoV-2 pneumonia.…”

Section: Introductionmentioning

confidence: 99%

“…4 The incidence of MP remains unclear but is estimated to be 5% to 15% in patients with invasive meningococcal disease. 5 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta-coronavirus that resulted in a worldwide pandemic starting in October 2019. 6 It leads to a wide range of clinical manifestations, from asymptomatic presentation to a severe form of acute respiratory infection requiring hospitalization and ventilator support.…”

Section: Introductionmentioning

confidence: 99%

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A Double Whammy Pneumonia: The First Reported Case of Concurrent Neisseria meningitidis and SARS-CoV-2 Pneumonia

Valdez

Sharma

Joshi

et al. 2022

Journal of Investigative Medicine High Impact Case Reports

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Meningococcal pneumonia (MP) is a rare manifestation of meningococcal disease. The MP was first described in 1907 when Neisseria meningitidis (NM) isolates were identified in sputum samples obtained from soldiers with pneumonia. Preceding and concurrent viral infections constitute a major risk for MP. During the 1918-1919 influenza pandemic, a significant increase in MP cases were reported in patients with preceding influenza infection. Despite the end of the last H1N1 influenza pandemic in 2010, seasonal influenza infections still pose a risk for simultaneous MP. History appears to be repeating itself with concomitant bacterial and viral coinfection amid the current SARS-CoV-2 pandemic. Herein presented is a unique case of an elderly woman who presented with, to the best of our knowledge, the first reported case of possible concurrent SARS-CoV-2 and MP infections.

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Pneumonia caused by Neisseria animaloris in a cat

Jeong,

Cheon,

Park

2024

Korean J Vet Res

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Neisseria meningitidis pneumonia with bacteremia without meningitis: An atypical presentation

Cited by 8 publications

References 6 publications

Ear mite infection restructures otic microbial networks in conservation–reliant Santa Catalina Island foxes (Urocyon littoralis catalinae)

Ear mite infection restructures otic microbial networks in conservation–reliant Santa Catalina Island foxes (Urocyon littoralis catalinae)

A Double Whammy Pneumonia: The First Reported Case of Concurrent Neisseria meningitidis and SARS-CoV-2 Pneumonia

Pneumonia caused by Neisseria animaloris in a cat

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