Neisseria meningitidis endocarditis: A case report and review of the literature

Ali, Mohammed; McAdam, Brendan

doi:10.3109/00365548.2011.572910

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…meningitidis was more common before the antibiotic era with a trend of affecting the left side of the heart. Since 1960s, meningococcal IE has become a rare disease with only 13 reported cases (25). Nevertheless, N .…”

Section: Resultsmentioning

confidence: 99%

Rare Case of Community-Acquired Endocarditis Caused by Neisseria meningitidis Assessed by Clinical Metagenomics

Choutko¹,

Lazarević²,

Gaïa³

et al. 2019

Front. Cardiovasc. Med.

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The most common causes of infective endocarditis (IE) are Staphylococcus, Streptococcus, Enterococcus , and HACEK-related organisms. In 15–30% of the IE cases, standard blood cultures remain sterile. We aimed at identifying the causative agent of a blood-culture-negative IE by whole metagenome shotgun sequencing (WMGS). A 54-year old woman diagnosed with community-onset pneumonia by a general practitioner, was admitted with dyspnea, cough and fever. The patient's blood cultures were repeatedly negative. The transesophageal echocardiography and transthoracic echocardiography showed an echo density on the left coronary leaflet of the aortic valve and signs suggestive of a ruptured abscess of the mitro-aortic junction. The patient underwent a semi-urgent aortic valve replacement by a mechanical prosthetic valve. We extracted DNA from the surgically-removed fresh valve tissue. The extraction procedure included bacterial/fungal DNA enrichment procedure. Nextera XT library prepared from the valve DNA extract was sequenced (2 × 250) on an Illumina MiSeq instrument. Sequence reads were mapped against bacterial genomic sequences, 16S rRNA genes and clade-specific taxonomic markers. Most of the 103,136 sequencing reads classified as bacterial were assigned to Neisseria meningitidis . In line with these data, mapping of reads against clade-specific and 16S rRNA gene markers revealed N . meningitidis as the most represented species. Assembled metagenomic fragments had the best average nucleotide identity (ANI) with N . meningitidis . Comparison of assembled contigs to reference alleles showed that this strain belongs to the ST-41/44 complex. N. meningitidis is commonly associated with meningitis and/or septicemia but should not be neglected as a causative agent of IE, which became exceedingly rare with the introduction of antibiotics. Our data show that WMGS may be used as a diagnostic procedure to strengthen the diagnosis of IE and to obtain draft genomic sequence of the pathogen and typing information.

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Section: Resultsmentioning

confidence: 99%

Rare Case of Community-Acquired Endocarditis Caused by Neisseria meningitidis Assessed by Clinical Metagenomics

Choutko¹,

Lazarević²,

Gaïa³

et al. 2019

Front. Cardiovasc. Med.

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“…Systemic infections caused by NM vary in their severity, ranging from transient bacteremia to fulminant infection with a high mortality rate. The most common forms of systemic meningococcal infection include meningitis and meningococcemia with or without concomitant meningitis [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Native valve Neisseria meningitidis endocarditis with embolic infarcts

Hegde

Nikolaeva

Johnstone

2020

IDCases

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“…1,16 Other less commonly observed localized infections associated with N meningitidis include pneumonia, pericarditis, endocarditis, supraglottitis, conjunctivitis, urethritis, and otitis media. 1,[17][18][19][20][21][22] Fortunately, the incidence of meningococcal infection in high-income countries is low (from <1 to 5 cases per 100,000 people), with a bimodal distribution peaking in children younger than 4 years and teenagers between 15 and 19 years old. 1,[23][24][25][26] However, during epidemics in low-income countries throughout the "meningitis belt" in sub-Saharan Africa, the incidence can reach as high as 1000 cases per 100,000 people.…”

Section: Pathogenesismentioning

confidence: 99%