Neighboring inteins interfere with one another's homing capacity
Israela Turgeman-Grott,
Danielle Arsenault,
Dekel Yahav
et al.
Abstract:Inteins are mobile genetic elements that invade conserved genes across all domains of life and viruses. In some instances, a single gene will have several intein insertion sites. In Haloarchaea, the mini-chromosome maintenance (MCM) protein at the core of replicative DNA helicase contains four intein insertion sites within close proximity, where two of these sites (MCM-a and MCM-d) are more likely to be invaded. A haloarchaeon which harbors both MCM-a and MCM-d inteins, Haloferax mediterranei, was studied in v… Show more
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