Neighborhood Socioeconomic Deprivation in Young Adulthood and Future Respiratory Health: The CARDIA Lung Study

Thatipelli, Sneha; Kershaw, Kiarri N.; Colangelo, Laura A.; Gordon‐Larsen, Penny; Jacobs, David R.; Meza, Daniel; Rosenberg, Sharon R; Washko, George R.; Parekh, Trisha M; Carnethon, Mercedes R.; Kalhan, Ravi

doi:10.1016/j.amjmed.2021.07.048

Cited by 9 publications

(3 citation statements)

References 30 publications

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“…As many of the associations were seen between FVC and PM 2.5 , PM 10 and NO 2 , this highlights the importance of concerted efforts to reduce road traffic and fossil-fuel burning vehicle engines in urban areas to prevent further detrimental effects on preterm-born children’s respiratory function. We did not see a significant association between deprivation and lung function in univariable modelling for our cohort, however, deprivation has been linked to higher air pollution exposure, 39 respiratory morbidity and decline in lung function 40 41 in other studies.…”

Section: Discussioncontrasting

confidence: 92%

Impact of ambient air pollution on lung function in preterm-born school-aged children

Watkins,

Course,

Cousins

et al. 2024

Thorax

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RationaleIncreased outdoor air pollution worsens lung function in children. However, these associations are less well studied in preterm-born individuals.ObjectivesWe assessed associations between ambient air pollutants and spirometry measures in preterm-born children.MethodsThe Respiratory Health Outcomes in Neonates study recruited preterm-born children aged 7–12 years who were born at ≤34 week's gestation. We associated four ambient air pollutants (particulate matter with aerodynamic diameter ≤2.5 µm (PM2.5), PM10, nitrogen dioxide (NO2) and sulfur dioxide) at time of birth and spirometry assessment and averaged exposure between these two time points with spirometry measures, using linear regression analyses. Gestational age was banded into 23–28, 29–31 and 32–34 week's. Regression models estimated spirometry values against pollutant levels at birth and at the time of spirometry.Measurements and main resultsFrom 565 preterm-born children, 542 (96%) had satisfactory data. After adjustments for early and current life factors, significant detrimental associations were noted between PM10at birth and per cent predicted forced vital capacity (%FVC) for the 23–28 and 29–31 week's gestation groups and between current PM2.5and NO2exposure and %FVC for the 23–28 week's gestation group. No associations with spirometry were noted for the averaged pollution exposure between birth and spirometry. Predictive models showed 5.9% and 7.4% differences in %FVC between the highest and lowest current pollution exposures for PM2.5and NO2,respectively, in the 23–28 week group.ConclusionsBirth and current exposures to road-traffic-associated pollutants detrimentally affected %FVC in preterm-born school-aged children, who already have compromised lung function.

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Section: Discussioncontrasting

confidence: 92%

Impact of ambient air pollution on lung function in preterm-born school-aged children

Watkins,

Course,

Cousins

et al. 2024

Thorax

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“…Extensive quality control of the measurement devices was carried out during each exam as well as between examinations, using waveform analysis to check comparability when a different device was used in one exam than in another [ 13 ]. Annualized lung function decline was calculated by subtracting spirometry parameters at year 30 from those parameters at each participant’s estimated peak lung function and dividing by the difference in years, as has been done previously in this cohort [ 14 ]. If year 30 data were not available, year 20 data were used.…”

Section: Methodsmentioning

confidence: 99%

Associations of a plant-centered diet and lung function across early to mid-adulthood: The CARDIA Lung Study

Wharton,

Wang,

Choi

et al. 2024

Respir Res

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Background Lung function throughout adulthood predicts morbidity and mortality even among adults without chronic respiratory disease. Diet quality may represent a modifiable risk factor for lung function impairment later in life. We investigated associations between nutritionally-rich plant-centered diet and lung function across early and middle adulthood from the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Methods Diet was assessed at baseline and years 7 and 20 of follow-up using the validated CARDIA diet history questionnaire. Plant-centered diet quality was scored using the validated A Priori Diet Quality Score (APDQS), which weights food groups to measure adherence to a nutritionally-rich plant-centered diet for 20 beneficially rated foods and 13 adversely rated foods. Scores were cumulatively averaged over follow-up and categorized into quintiles. The primary outcome was lung function decline, including forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), measured at years 0, 2, 5, 10, 20, and 30. We estimated the association of APDQS with annual pulmonary function changes and cross-sectional differences in a repeated measures regression model, adjusting for clinically relevant covariates. Results The study included 3,787 Black and White men and women aged 18–30 in 1985–86 and followed for 30 years. In multivariable repeated measures regression models, individuals in the lowest APDQS quintile (poorest diet) had declines in FEV1 that were 1.6 ml/year greater than individuals in the highest quintile (35.0 vs. 33.4 ml/year, ß ± SE per 1 SD change APDQS 0.94 ± 0.36, p = 0.009). Additionally, declines in FVC were 2.4 ml/year greater in the lowest APDQS quintile than those in the highest quintile (37.0 vs 34.6 ml/year, ß ± SE per 1 SD change APDQS 1.71 ± 0.46, p < 0.001). The association was not different between never and ever smokers (pint = 0.07 for FVC and 0.32 for FEV1). In sensitivity analyses where current asthma diagnosis and cardiorespiratory fitness were further adjusted, results remained similar. Cross-sectional analysis at each exam year also showed significant differences in lung function according to diet after covariate adjustment. Conclusions In this 30-year longitudinal cohort study, long-term adherence to a nutritionally-rich plant-centered diet was associated with cross-sectional differences in lung function as well as slower decline in lung function, highlighting diet quality as a potential treatable trait supporting long-term lung health.

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“…Extensive quality control of the measurement devices was carried out during each exam as well as between examinations, using waveform analysis to check comparability when a different device was used in one exam than in another (13). Lung function decline was calculated by subtracting spirometry parameters at year 30 from those parameters at each participant's estimated peak lung function and dividing by the difference in years, as has been done previously in this cohort (14). If year 30 data were not available, year 20 data were used.…”

Section: Assessment Of Outcome Variablesmentioning

confidence: 99%

Associations of a Plant Centered Diet and Lung Function Decline Across Early to Mid-adulthood: The Cardia Lung Study

Wharton

Wang

Choi

et al. 2023

A99. Clinical Trials in Chronic Lung Disease

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BackgroundLung function throughout adulthood predicts morbidity and mortality even among adults without chronic respiratory disease. Diet quality may represent a modi able risk factor for lung function impairment later in life. We investigated associations between nutritionally-rich plant-centered diet and lung function decline across early and middle adulthood from the Coronary Artery Risk Development in Young Adults (CARDIA) Study. MethodsDiet was assessed at baseline and years 7 and 20 of follow-up using the validated CARDIA diet history questionnaire. Plant-centered diet quality was scored using the validated A Priori Diet Quality Score (APDQS), which weights food groups to measure adherence to a nutritionally-rich plant-centered diet 1 to 5 points for 20 bene cially rated foods and 5 to 1 points for 13 adversely rated foods. Scores were cumulatively averaged over follow-up and categorized into quintiles. The primary outcome was lung function decline, including forced expiratory volume in 1 second (FEV 1 ) and functional vital capacity (FVC), measured at years 0, 2, 5, 10, 20, and 30. We estimated the association of APDQS with annual pulmonary function changes in a repeated measures regression model, adjusting for clinically relevant covariates. ResultsThe study included 3,787 Black and White men and women aged 18-30 in 1985-86 and followed for 30 years. In multivariable repeated measures regression models, individuals in the lowest APDQS quintile (poorest diet) had declines in FEV 1 that were 1.6 ml/year greater than individuals in the highest quintile (35.0 vs. 33.4 ml/year, ß±SE per 1 SD change APDQS 0.94 ± 0.36, p = 0.009). Additionally, declines in FVC were 2.4 ml/year greater in the lowest APDQS quintile than those in the highest quintile (37.0 vs 34.6 ml/year, ß±SE per 1 SD change APDQS 1.71 ± 0.46, p < 0.001). The association was not different between never and ever smokers (p int = 0.07 for FVC and 0.32 for FEV 1 ). In sensitivity analyses where current asthma diagnosis and cardiorespiratory tness were further adjusted, results remained similar. ConclusionsIn this 30-year longitudinal cohort study, long-term adherence to a nutritionally-rich plant-centered diet was associated with slower decline in lung function, highlighting diet quality as a potential treatable trait supporting long-term lung health.

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Neighborhood Socioeconomic Deprivation in Young Adulthood and Future Respiratory Health: The CARDIA Lung Study

Cited by 9 publications

References 30 publications

Impact of ambient air pollution on lung function in preterm-born school-aged children

Impact of ambient air pollution on lung function in preterm-born school-aged children

Associations of a plant-centered diet and lung function across early to mid-adulthood: The CARDIA Lung Study

Associations of a Plant Centered Diet and Lung Function Decline Across Early to Mid-adulthood: The Cardia Lung Study

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