Neighborhood social environment and changes in leukocyte telomere length: The Multi-Ethnic Study of Atherosclerosis (MESA)

Brown, Rashida; Hailu, Elleni M.; Needham, Belinda L.; Roux, Ana Diez; Seeman, Teresa E.; Lin, Jue; Mujahid, Mahasin S.

doi:10.1016/j.healthplace.2020.102488

Cited by 8 publications

(6 citation statements)

References 61 publications

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“…Usually, there are significant differences between heroin-dependent patients and the general population for numerous social and socioeconomic factors. It should be noted that cross-sectional and longitudinal study designs supported the association of many social and socioeconomic contexts with telomere length (Normando et al, 2020;Brown et al, 2021). It is not clear that the shortening of telomere length was occurred by heroin (morphine) or by some other confounding factors.…”

Section: Resultsmentioning

confidence: 99%

Morphine may have a role in telomere shortening

Darvishi

Saadat

2021

Psychiatric Genetics

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Morphine/heroin may increase oxidative stress in drug-dependent persons. The imbalance between oxidative stress and antioxidant defense mechanisms can accelerate the shortening of telomere length. This article reports two sets of data; comparison of relative telomere length between heroin-dependent patients and healthy control group, as well as, investigation of the effect of morphine on the relative telomere length of human SH-SY5Y cells treated by morphine. Study participants were composed of 163 heroin-dependent patients and 166 unrelated healthy controls. SH-SY5Y cells were treated with (5 μM) morphine hydrochloride and incubated for 40 and 60 days. The relative telomere length was calculated as the T/S (telomere/single-copy gene) ratio using 36B4 as a reference for each sample, using quantitative real-time PCR. The mean (± SE) value of relative telomere length was 4.81 ± 0.21 and 6.38 ± 0.23 in leukocytes of heroin-dependent and control groups, respectively. The telomere length was significantly decreased in heroin-dependent participants (t = 4.97; df = 327; P < 0.0001). The relative telomere length in cells treated with morphine for 60 days was 4.50 ± 0.14 and in untreated cells was 5.75 ± 0.08. The difference was highly significant (t = 7.68; df = 4; P = 0.002). Our present findings indicate that morphine and dependency on heroin are significantly associated with shorter telomeres. The present findings may help to explain some of the adverse effects of drug dependency on health such as accelerating biologic processes related to aging.

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Section: Resultsmentioning

confidence: 99%

Morphine may have a role in telomere shortening

Darvishi

Saadat

2021

Psychiatric Genetics

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“…Brown et al . found that a good neighborhood is linked to longer telomeres, impacting telomere length through factors, such as aesthetics, availability of green spaces and socioeconomic status 30 …”

Section: Discussionmentioning

confidence: 99%

“…Brown et al found that a good neighborhood is linked to longer telomeres, impacting telomere length through factors, such as aesthetics, availability of green spaces and socioeconomic status. 30 Alexeeff et al showed that neighborhood socioeconomic status can influence telomere shortening, with lower socioeconomic status correlating with shorter telomeres. 31 A study on blackbirds showed that forest-dwelling birds possess longer telomeres compared with their urban counterparts.…”

Section: Enrollment Analysismentioning

confidence: 99%

Association between the anthropometric measurements and dietary habits on telomere shortening in healthy older adults: A‐cross‐sectional study

Barcın‐Güzeldere

Aksoy

Demircan

et al. 2023

Geriatrics Gerontology Int

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This study aimed to evaluate the effect of anthropometric measurements and dietary habits on telomere length in healthy older residents in rural and urban areas.Methods: This was a cross-sectional study. The study population included 81 healthy older individuals aged ≥80 years. A quantitative food frequency questionnaire was used to determine dietary habits. Anthropometric measurements were taken by researchers. The telomere length of individuals was determined from leukocytes using quantitative polymerase chain reaction.Results: Urban women had longer telomeres than rural women (P < 0.05). Rural men had significantly higher hip circumference, middle-upper arm circumference and fat-free mass than urban men (P < 0.05). It was shown that while fresh vegetable consumption was higher in rural areas, carbonated drink consumption was higher in urban areas (P < 0.05). In women, homemade bread and sugar consumption were higher in rural areas, and honey consumption was higher in urban (P < 0.05). Red meat, milk-based dessert and pastry consumption explain telomere shortening by 22.5%, 24.8% and 17.9%, respectively. In addition, the model based on anthropometric measurements also contributes to explaining telomere shortening by 42.9%. Conclusion:Red meat, milk-based dessert and pastry consumption, and waist circumference, hip circumference, waist-to-hip ratio and waist-to-height ratio are associated with telomere length. Longer telomeres are associated with a healthy, balanced, adequate diet and maintaining a healthy body weight/proportion, and they are crucial for achieving healthy aging.

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“…Another cross sectional study of n = 341 mixed race participants found that younger adults with higher burden of discrimination (race and sex) had shorter TL, while similar associations were reported among female from higher SES strata 21 . A recent longitudinal study of n = 1,031 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) reported that improvements in neighbourhood-level SES were protective on the rate of telomere attrition 22 .…”

Section: Introductionmentioning

confidence: 99%

The associations of socioeconomic status with incident dementia and Alzheimer’s disease are modified by leucocyte telomere length: a population-based cohort study

Lai

Webster

Kumari

et al. 2023

Sci Rep

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Socio-economic status (SES) and biological aging are risk factors for dementia, including Alzheimer’s disease, however, it is less clear if the associations with SES vary sufficiently across different biological age strata. We used data from 331,066 UK Biobank participants aged 38–73 with mean follow-up of 12 years to examine if associations between SES (assessed by educational attainment, employment status and household income) and dementia and Alzheimer’s disease are modified by biological age (assessed by leucocyte telomere length: LTL). Diagnosis of events was ascertained through hospital admissions data. Cox regressions were used to estimate hazard ratios [HRs]. A consistent dose–response relationship was found, with participants in low SES and shorter LTL strata (double-exposed group) reporting 3.28 (95% confidence interval [CI] 2.57–4.20) and 3.44 (95% CI 2.35–5.04) times higher risks of incident dementia and Alzheimer’s disease respectively, compared to those of high SES and longer LTL (least-exposed group). Of interest is a synergistic interaction between SES and LTL to increase risk of dementia (RERI 0.57, 95% CI 0.07–1.06) and Alzheimer’s disease (RERI 0.79, 95% CI 0.02–1.56). Our findings that SES and biological age (LTL) are synergistic risk factors of dementia and Alzheimer’s disease may suggest the need to target interventions among vulnerable sub-groups.

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Neighborhood social environment and changes in leukocyte telomere length: The Multi-Ethnic Study of Atherosclerosis (MESA)

Cited by 8 publications

References 61 publications

Morphine may have a role in telomere shortening

Morphine may have a role in telomere shortening

Association between the anthropometric measurements and dietary habits on telomere shortening in healthy older adults: A‐cross‐sectional study

The associations of socioeconomic status with incident dementia and Alzheimer’s disease are modified by leucocyte telomere length: a population-based cohort study

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