Neighborhood deprivation and obesity: Sex-specific effects of cross-sectional, cumulative and residential trajectory indicators

Letarte, Laurence; Samadoulougou, Sékou; McKay, Rachel; Quesnel‐Vallée, Amélie; Waygood, E. Owen D.; Lebel, Alexandre

doi:10.1016/j.socscimed.2022.115049

Cited by 4 publications

(7 citation statements)

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“…This finding is consistent with the life course theory, which suggests that accumulation of exposure to neighbourhood deprivation at different life stages may be harmful for SPH [4]. The results of this study support the existing evidence suggesting an association between long-term NDTs and poor health outcomes [2,19,24,[40][41][42]. Using NDTs, Letarte et al found that women exposed to disadvantaged trajectories (Deprived Upward, Average Downward, or Deprived Trajectory) had higher odds of living with obesity than those exposed to the Privileged trajectory [24].…”

Section: Key Resultssupporting

confidence: 91%

“…The results of this study support the existing evidence suggesting an association between long-term NDTs and poor health outcomes [2,19,24,[40][41][42]. Using NDTs, Letarte et al found that women exposed to disadvantaged trajectories (Deprived Upward, Average Downward, or Deprived Trajectory) had higher odds of living with obesity than those exposed to the Privileged trajectory [24]. Additionally, studies using similar NDTs found that neighbourhood deprivation was associated with diabetes [7], psychological distress [19], weight gain [40,43] and intimate partner violence [41].…”

Section: Key Resultssupporting

confidence: 88%

“…Second, the NDTs of study participants can begin at different age periods, from childhood to late adulthood. It is possible that adjustment of the study analyses for age is not sufficient to minimise the differential life-stage effect of exposure to neighbourhood deprivation on health status [24]. Third, because SPH was evaluated at a single time point, the observed associations may be biased by reverse causality and neighbourhood self-selection; the latter was found to be a minor source of bias in health studies [52].…”

Section: Strengths and Limitationsmentioning

confidence: 99%

“…These mechanisms can affect health outcomes differently, and they should be assessed using different indicators. Nuanced indicators, allowing the modelling of different mechanisms of exposure to neighbourhood deprivation, could reveal important information that was previously neglected for the prevention of health issues [2,24].…”

Section: Introductionmentioning

confidence: 99%

“…This study is part of larger research interested in the creation of indicators of neighbourhood deprivation trajectories (NDTs) for the population of Quebec, Canada. NDTs constitute a measure of long-term exposure to deprivation; for example, it examines the sequence of exposure to greater neighbourhood-level deprivation [24,29]. Sequence analysis based on optimal matching and clustering around theoretical types has been used to construct an indicator of NDTs [29].…”

Section: Introductionmentioning

confidence: 99%

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Association between Neighbourhood Deprivation Trajectories and Self-Perceived Health: Analysis of a Linked Survey and Health Administrative Data

Samadoulougou

Letarte

Lebel³

2022

IJERPH

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Life course exposure to neighbourhood deprivation may have a previously unstudied relationship with health disparities. This study examined the association between neighbourhood deprivation trajectories (NDTs) and poor reported self-perceived health (SPH) among Quebec’s adult population. Data of 45,990 adults with complete residential address histories from the Care-Trajectories-Enriched Data cohort, which links Canadian Community Health Survey respondents to health administrative data, were used. Accordingly, participants were categorised into nine NDTs (T1 (Privileged Stable)–T9 (Deprived Stable)). Using multivariate logistic regression, the association between trajectory groups and poor SPH was estimated. Of the participants, 10.3% (95% confidence interval [CI]: 9.9–10.8) had poor SPH status. This proportion varied considerably across NDTs: From 6.4% (95% CI: 5.7–7.2) for Privileged Stable (most advantaged) to 16.4% (95% CI: 15.0–17.8) for Deprived Stable (most disadvantaged) trajectories. After adjustment, the likelihood of reporting poor SPH was significantly higher among participants assigned to a Deprived Upward (odds ratio [OR]: 1.77; 95% CI: 1.48–2.12), Average Downward (OR: 1.75; CI: 1.08–2.84) or Deprived trajectory (OR: 1.81; CI: 1.45–2.86), compared to the Privileged trajectory. Long-term exposure to neighbourhood deprivation may be a risk factor for poor SPH. Thus, NDT measures should be considered when selecting a target population for public-health-related interventions.

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Section: Key Resultssupporting

confidence: 91%

Section: Key Resultssupporting

confidence: 88%

Section: Strengths and Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Association between Neighbourhood Deprivation Trajectories and Self-Perceived Health: Analysis of a Linked Survey and Health Administrative Data

Samadoulougou

Letarte

Lebel³

2022

IJERPH

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Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling

Baumer,

Singh,

Baez

et al. 2023

Preprint

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SummaryAdverse social determinants of health (aSDoH) are associated with obesity and related comorbidities like diabetes, cardiovascular disease, and cancer. Obesity is also associated with natural killer cell (NK) dysregulation, suggesting a potential mechanistic link. Therefore, we measured NK phenotypes and function in a cohort of African-American (AA) women from resource-limited neighborhoods. Obesity was associated with reduced NK cytotoxicity and a shift towards a regulatory phenotype.In vitro, LDL promoted NK dysfunction, implicating hyperlipidemia as a mediator of obesity-related immune dysregulation. Dual specific phosphatase 1 (DUSP1) was induced by LDL and was upregulated in NK cells from subjects with obesity, implicating DUSP1 in obesity-mediated NK dysfunction.In vitro, DUSP1 repressed LAMP1/CD107a, depleting NK cells of functional lysosomes to prevent degranulation and cytokine secretion. Together, these data provide novel mechanistic links between aSDoH, obesity, and immune dysregulation that could be leveraged to improve outcomes in marginalized populations.

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Associations between neighborhood stress and maternal sex steroid hormones in pregnancy

Hansel,

Murphy,

Brunner

et al. 2023

BMC Pregnancy Childbirth

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Background Neighborhood stressors (e.g., crime and deprivation) have been associated with adverse pregnancy outcomes including preterm birth and low birth weight. A potential mechanism is disruption of maternal endocrine pathways. While stress hormones (e.g., cortisol) have received much attention, other relevant hormones, including sex steroids, have been overlooked. Methods Pregnant women in the Understanding Pregnancy Signals and Infant Development (UPSIDE) study contributed biospecimens, questionnaires, and medical record data (n = 262). In each trimester, maternal serum total testosterone [TT], estrone, estradiol, and estriol were measured using LC/MS-MS and serum free testosterone was measured by equilibrium dialysis. In the third trimester, participants reported on neighborhood stress over the last year through the validated City Stress Inventory. We examined two subscales: 11-item neighborhood disorder (e.g., vacant buildings, crime) and 7-item exposure to violence (personal experiences of violence). Composite scores were calculated and examined categorically (quartile (Q) for neighborhood disorder and any/none for exposure to violence). We fitted linear mixed models examining associations between neighborhood stressors and sex steroid hormones across pregnancy as well as trimester-specific linear regression models, all adjusting for confounders. Secondarily, we stratified by fetal sex. Results are presented as percentage change (∆%) and 95% confidence interval (CI) in hormones. Results Most participants (73%) reported one or more exposures to neighborhood disorder; 22% reported any exposure to violence. In adjusted models, neighborhood disorder was associated with higher TT across pregnancy (Q2: %∆= 37.3, 95%CI: 13.2, 66.5; Q3: %∆= 22.2, 95%CI: 1.2, 47.5; and Q4: %∆= 25.7, 95%CI: 1.6, 55.3), with the strongest associations observed in the third trimester (Q2: %∆= 38.0, 95%CI: 10.6, 72.1; Q3: %∆= 29.2, 95%CI: 4.4, 59.9; and Q4: %∆=33.4, 95%CI: 4.9, 69.6). In stratified models, neighborhood disorder was associated with higher TT among women carrying male fetuses (%∆ range: 48.2–84.8). Exposure to violence was not associated with any hormones. Conclusion Neighborhood disorder is associated with higher maternal testosterone levels, which may have implications for maternal and child health. Additional research is needed to understand the mechanisms by which neighborhood stress impacts endocrine physiology.

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Neighborhood deprivation and obesity: Sex-specific effects of cross-sectional, cumulative and residential trajectory indicators

Cited by 4 publications

References 73 publications

Association between Neighbourhood Deprivation Trajectories and Self-Perceived Health: Analysis of a Linked Survey and Health Administrative Data

Association between Neighbourhood Deprivation Trajectories and Self-Perceived Health: Analysis of a Linked Survey and Health Administrative Data

Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling

Associations between neighborhood stress and maternal sex steroid hormones in pregnancy

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