Negative Symptoms in Schizophrenia: Their Longitudinal Course and Prognostic Importance

Pogue-Geile, Michael F.; Harrow, Martin

doi:10.1093/schbul/11.3.427

Cited by 325 publications

(122 citation statements)

References 43 publications

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“…Recent investigations by Biehl (94), Beiser et al (32) and by Carpenter et al (95) suggest that the presence of the negative symptoms of schizophrenia predicts poor outcome. Recently, however, Husted (57) using findings from the MAP project and other studies (96,97), found no evidence that the presence of negative symptoms at first treatment predicted the level of symptoms at follow-up. While negative symptoms did appear to predict social functioning at follow-up, this effect disappeared when level of premorbid associality and insidiousness of onset were controlled.…”

Section: The Course Of Schizophreniamentioning

confidence: 97%

An Update on the Epidemiology of Schizophrenia^*

Beiser

Iacono

1990

Can J Psychiatry

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While recent developments such as brain imaging and genetic linkage analysis have been rightly hailed as potential breakthroughs in the investigation of etiology, new technologies must not divert attention from basic problems which continue to hamper research in the field, or encourage the acceptance of overly simplistic answers to a complicated question. In order to study its etiology, a disorder must be clearly defined. While the precision of systems like the RDC (2) and the DSM-III-R (3) has improved diagnostic reliability, these systems are merely a convenient, shared illusion about how best to categorize a still elusive disorder. Conceptualizing the nature and critical features of schizophrenia is important to the mental health field.

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Section: The Course Of Schizophreniamentioning

confidence: 97%

An Update on the Epidemiology of Schizophrenia^*

Beiser

Iacono

1990

Can J Psychiatry

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“…The measure of negative symptoms is designed to assess flat affect, poverty of speech, and psychomotor retardation/poverty. Individual items were combined into three subscales reflecting poverty of speech, flat affect, and psychomotor retardation (38,39). Intraclass correlations between raters were 0.96 for the poverty of speech scale, 0.86 for the flat affect scale, and 0.85 for the psychomotor retardation/poverty scale.…”

Section: Followup Assessmentmentioning

confidence: 99%

Sex differences in schizophrenia and other psychotic disorders: a 20-year longitudinal study of psychosis and recovery

Grossman

Harrow

Rosen

et al. 2008

Comprehensive Psychiatry

142

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This longitudinal study was designed to provide data on sex differences in the course of illness in schizophrenia and other psychotic disorders. Ninety-seven participants (43 women and 54 men) were assessed during index hospitalization when they were in the acute phase of illness, and then reassessed prospectively at 6 consecutive followups over a 20 year period. Patients were evaluated by a series of standardized measures on many aspects of illness including the presence of psychosis, global outcome, and rate of recovery. When women were compared to men in this sample, the data demonstrated a lower percentage of psychotic activity for women over the course of illness (significant at the 7.5 and 20 year followups), and a significant improvement in psychotic activity over 20 years for women (p<.05), but not for men. Additionally, women showed significantly better global functioning (p<.05) at 3 of the 6 followups (the 2, 7.5, and 10-year followups). Significantly higher percentages (p<.05) of women were in recovery at 2 of the 6 followup years (the 2 and 10-year followups). Cumulatively, 61% of the women with schizophrenia showed a period of recovery at some point during the 20 year period, compared to 41% of the men. The sex difference patterns were similar for patients with schizophrenia and for those with other types of psychotic disorders. Sex differences in this sample were specifically not attributable to differences in age of onset or premorbid developmental achievements.

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“…Indeed, negative symptoms have been linked to poor quality of life in individuals with schizophrenia (Hunter and Barry, 2012;Foussias et al, 2014), decreased independent living, functional capacity, and social and role functioning (Pogue-Geile and Harrow, 1985;Bowie et al, 2006;Kring et al, 2013;Fervaha et al, 2014). Moreover, evidence shows that negative symptoms contribute to poor functioning more than positive symptoms of schizophrenia (Rabinowitz et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Expectancies of success as a predictor of negative symptoms reduction over 18 months in individuals with schizophrenia

Luther

Fukui

Firmin

et al. 2015

Psychiatry Research

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(2015). Expectancies of success as a predictor of negative symptoms reduction over 18 months in individuals with schizophrenia. Psychiatry Research, 229(1-2), 505-510. http://doi.org/10.1016/j.psychres.2015.06.022Running head: EXPECTANCIES OF SUCCESS AND NEGATIVE SYMPTOMS  We examine expectancies of success-beliefs of future success and goal attainment.  118 individuals with schizophrenia-spectrum disorders completed an 18 month study.  High and moderate expectancies of success predicted reduced negative symptoms.  Findings support the cognitive model of negative symptoms. *HighlightsRunning head: EXPECTANCIES OF SUCCESS AND NEGATIVE SYMPTOMS EXPECTANCIES OF SUCCESS AND NEGATIVE SYMPTOMS 2 AbstractNegative symptoms are often enduring and lead to poor functional outcomes in individuals with schizophrenia. The cognitive model of negative symptoms proposes that low expectancies of success contribute to the development and maintenance of negative symptoms; however, longitudinal investigations assessing these beliefs and negative symptoms are needed. The current study examined whether an individual's baseline expectancies of success--one's beliefs about future success and goal attainment--predicted negative symptom reduction over 18 months in individuals with schizophrenia-spectrum disorders (n = 118). Data were collected at baseline, 9 months, and 18 months as part of a randomized controlled trial of Illness Management and Recovery. A mixed effects regression analysis revealed a significant reduction in negative symptoms over time, with a significant interaction effect between time and baseline expectancies of success. After controlling for baseline negative symptoms, demographic variables, and treatment conditions, those with high and moderate baseline expectancies of success evidenced a significant reduction in negative symptoms at 18 months, while those with low baseline expectancies of success did not evidence reduced negative symptoms. Findings support the cognitive model of negative symptoms and suggest that expectancies of success may be a useful treatment target for interventions aimed at reducing negative symptoms.

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Negative Symptoms in Schizophrenia: Their Longitudinal Course and Prognostic Importance

Cited by 325 publications

References 43 publications

An Update on the Epidemiology of Schizophrenia^*

An Update on the Epidemiology of Schizophrenia^*

Sex differences in schizophrenia and other psychotic disorders: a 20-year longitudinal study of psychosis and recovery

Expectancies of success as a predictor of negative symptoms reduction over 18 months in individuals with schizophrenia

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Negative Symptoms in Schizophrenia: Their Longitudinal Course and Prognostic Importance

Cited by 325 publications

References 43 publications

An Update on the Epidemiology of Schizophrenia*

An Update on the Epidemiology of Schizophrenia*

Sex differences in schizophrenia and other psychotic disorders: a 20-year longitudinal study of psychosis and recovery

Expectancies of success as a predictor of negative symptoms reduction over 18 months in individuals with schizophrenia

Contact Info

Product

Resources

About

An Update on the Epidemiology of Schizophrenia^*

An Update on the Epidemiology of Schizophrenia^*