Negative symptoms in first episode non‐affective psychosis

Malla, Ashok; Takhar, Jatinder; Norman, Ross; Manchanda, Rahul; Cortese, Leonard; Haricharan, Raj; Verdi, Mary; Ahmed, R

doi:10.1034/j.1600-0447.2002.02139.x

Cited by 107 publications

(88 citation statements)

References 39 publications

(43 reference statements)

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“…less than 9 months) might therefore have a greater impact on negative symptoms than the same reduction in someone with a DUP greater than nine months. These findings are in accordance with the findings of the TIPS study and the study of Malla et al (2002Malla et al ( , 2004, both of which suggested that reduction of DUP may be as important for improving the severity of negative symptoms as it is for positive symptoms (Melle et al, 2008). Our finding of a non-linear association between DUP and negative symptoms is similar to that reported by Drake et al for total PANSS scores (Drake et al, 2000) albeit in a small sample with a short follow-up.…”

Section: Discussionsupporting

confidence: 93%

“…Negative symptoms are associated with poor functional outcome (Malla et al, 2004), cognitive deficits (Heydebrand et al, 2004), social dysfunction and poor quality of life (Addington and Addington, 1993;Schmitz et al, 2007;Petersen et al, 2008). Negative symptoms are common: the prevalence in short-term follow-up studies (up to 2.5 years) is about 45% (Pogue-Geile and Harrow, 1985;Malla et al, 2002Malla et al, , 2004, and in longer term studies (7.5-10 years) 20-30% (Herbener and Harrow, 2001). Schizophrenia Research 142 (2012) [12][13][14][15][16][17][18][19] There is no established treatment for primary negative symptoms (Kirkpatrick et al, 2006;Buckley and Stahl, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Boonstra

Klaassen

Sytema

et al. 2012

Schizophrenia Research

210

134

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Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Background: Longer duration of untreated psychosis (DUP) is associated with poorer outcome in terms of positive symptoms, relapse rate, and time to remission. In contrast, the association with negative symptoms is less consistent. Aims: The study had three aims. First, to arrive at a more precise estimate of the correlation between DUP and negative symptoms than previous reviews, by substantially increasing the amount of available data. Second, to see whether the strength of this correlation attenuated over longer follow-up intervals. Third, to determine whether there is a relationship between DUP and changes in negative symptoms. Method: Relevant databases were searched for studies published between December 1992 and March 2009 that reported data on DUP and negative symptoms. We obtained individual patient data where possible and calculated summary correlations between DUP and negative symptoms for each study at baseline, short and long-term follow-up. We used multilevel regression analysis to examine whether the effect of DUP on negative symptoms was the greatest in the early stages of illness. Results: We included 28 non-overlapping studies from the 402 papers detected by the search strategy. After contacting the authors we obtained individual patient data from 16 of these studies involving 3339 participants. The mean DUP was 61.4 weeks (SD = 132.7, median DUP = 12.0). Shorter DUP was significantly associated with less severe negative symptoms at baseline and also at short (1-2 years) and longer term follow-up (5-8 years) (r = 0.117, 0.180 and 0.202 respectively, p b 0.001). The relationship between improvement in negative symptoms and DUP was found to be non-linear: people with a DUP shorter than 9 months showed substantially greater negative symptom reduction than those with a DUP of greater than 9 months. Conclusions: Shorter DUP is associated with less severe negative symptoms at short and long-term follow up, especially when the DUP is less than 9 months. Since there is no effective treatment for negative symptoms, reducing DUP to less than 9 months may be the best way to ameliorate them.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Boonstra

Klaassen

Sytema

et al. 2012

Schizophrenia Research

210

134

View full text Add to dashboard Cite

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“…Moving beyond the definition itself, studies investigating the factor structure of the construct [87][88][89][90] have revealed that negative symptoms usually cohere into two distinct, yet related, subdomains: diminished expression, consisting of affective flattening and poverty of speech; and amotivation, consisting of avolition, apathy, asociality, and hedonic deficits. In addition, recent research has been focusing in further refining the negative symptom construct, with the majority of studies exploring the anhedonia and amotivation symptom domain.…”

Section: Negative Symptoms: Evolution Of the Conceptmentioning

confidence: 99%

“…Accordingly, in the early stages of the disease, at the first-ep-isode [89] and during the proceeding years [98,99], the presence of this symptom cluster is one of the greatest barriers to the achievement of functional recovery. Moreover, before full blown psychosis occurs, during the so-called high-risk (HR) or prodromal state, negative symptoms and impaired social cognition have been associated with marked impairment in psychosocial function [100,101] which appears to be a core feature of the HR state and tends to be resistant to all types of treatment [102].…”

Section: Negative Symptoms and Psychosocial Functioningmentioning

confidence: 99%

Social Cognition, Negative Symptoms and Psychosocial Functioning in Schizophrenia

Madeira¹,

Caldeira²,

Bajouco³

et al. 2016

IJCNMH

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Although functional recovery could be advocated as an achievable treatment goal, many effective interventions for the treatment of psychotic symptoms, such as antipsychotic drugs, may not improve functioning. The last two decades of cognitive and clinical research on schizophrenia were a turning point for the firm acknowledgment of how relevant social cognitive deficits and negative symptoms could be in predicting psychosocial functioning. The relevance of social cognition dysfunction in schizophrenia patients' daily living is now unabated. In fact, social cognition deficits could be the most significant predictor of functionality in patients with schizophrenia, non-redundantly with neurocognition. Emerging evidence suggests that negative symptoms appear to play an indirect role, mediating the relationship between neurocognition and social cognition with functional outcomes. Further explorations of this mediating role of negative symptoms have revealed that motivational deficits appear to be particularly important in explaining the relationship between both neurocognitive and social cognitive dysfunction and functional outcomes in schizophrenia. In this paper we will address the relative contribution of two key constructs-social cognitive deficits and negative symptoms, namely how intertwined they could be in daily life functioning of patients with schizophrenia.

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“…The domain of attention on the SANS was also excluded from our analysis, as factor analyses from previous studies have shown that this domain, unlike others, loads on both negative and disorganization dimensions. 35,36 We assessed depressive symptoms using the Calgary Depression Scale (CDS). 37 …”

Section: Instruments and Assessmentmentioning

confidence: 99%

Bipolar disorder risk gene FOXO6 modulates negative symptoms in schizophrenia: a neuroimaging genetics study

Shenker

Sengupta

Joober

et al. 2017

JPN

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Negative symptoms in first episode non‐affective psychosis

Abstract: Negative symptoms that are independent of the influence of positive symptoms, depression and extra pyramidal symptoms (EPS) are present in a substantial proportion of first episode psychosis patients and delay in seeking treatment is associated mainly with avolition and anhedonia.

Cited by 107 publications

References 39 publications

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Social Cognition, Negative Symptoms and Psychosocial Functioning in Schizophrenia

Bipolar disorder risk gene FOXO6 modulates negative symptoms in schizophrenia: a neuroimaging genetics study

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