Negative studies shape the state of sickle trait

Sickle Cell Trait: What Every Nurse Practitioner Should Know

“…20 Other studies reported no increased odds of heart failure, hypertension, diabetes, or metabolic syndrome in people with SCT. 4 This evidence offers some reassurance that SCT does not elevate the risk of cardiovascular and cerebrovascular complications.…”

“…1 However, erythrocytes stiffness, increased blood viscosity, and intravascular thrombosis have been reported in individuals with SCT in situations of severe volume depletion, hyperthermia, and reduced oxygen tension. 4 In extreme circumstances of high-intensity sports and military training, SCT has been shown to increase the risk of rhabdomyolysis and exercise-related sudden death. 4 Structural changes of red blood cells and impaired endothelial function account for other rare SCT complications such as venous thromboembolism and kidney damage.…”

“…4 In extreme circumstances of high-intensity sports and military training, SCT has been shown to increase the risk of rhabdomyolysis and exercise-related sudden death. 4 Structural changes of red blood cells and impaired endothelial function account for other rare SCT complications such as venous thromboembolism and kidney damage. However, the magnitude of the clinically relevant red blood cell sickling and intravascular thrombosis is much less in SCT persons than in SCD patients.…”