Negative regulation of biofilm development by the CUG‐Ser1 clade‐specific histone H3 variant is dependent on the canonical histone chaperone CAF‐1 complex in Candida albicans
Abstract:The CUG‐Ser1 clade‐specific histone H3 variant (H3VCTG) has been reported to be a negative regulator of planktonic to biofilm growth transition in Candida albicans. The preferential binding of H3VCTG at the biofilm gene promoters makes chromatin repressive for the biofilm mode of growth. The two evolutionarily conserved chaperone complexes involved in incorporating histone H3 are CAF‐1 and HIRA. In this study, we sought to identify the chaperone complex(es) involved in loading H3VCTG. We demonstrate that C. al… Show more
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