Negative-pressure wound therapy versus standard wound dressing in the treatment of diabetic foot amputation. A randomised controlled trial

Effectiveness and Safety of Negative-Pressure Wound Therapy for Diabetic Foot Ulcers

“…Of these trials, eight randomized controlled trials met all inclusion and exclusion criteria published between 2000 and 2011. [19][20][21][22][23][24][25][26] The eight studies involved 669 patients with diabetic foot ulcers. In three of these studies, foot ulcers were characterized using the Texas Diabetic Wound Classification System 19,25 and the Wagner Scale, 20 whereas in the remaining five studies, there were no descriptions on relevant information.…”

“…The clinical characteristics of the studies are presented in Table 1. Seven studies had high quality, as evaluated using modified Jadad rating scales (scores ≥4), [19][20][21][22][24][25][26] and one study had low quality (score 3). 23 Details of the methodologic quality of randomized controlled trials are summarized in Table 2.…”

“…19,20,25,26 It is known that the time to diabetic foot ulcer healing is closely correlated with concomitant diseases and the progress of diseases. The duration and baseline condition of ulcers were comparable in both groups in these four studies.…”

“…19,20,22,24,25 Two large studies concluded that negative-pressure wound therapy was associated with reduced time to 76 to 100 percent granulation tissue formation. 19,20 Etöz et al reported that the formation of granulation (until diabetic foot ulcers were covered with granulation tissue) in the negative-pressure wound therapy was faster compared with moist wound dressing.…”

“…19,20,25 Local wound infection was the most commonly reported adverse event. The pooling analysis of the three studies revealed no significant difference in the overall adverse events between negative-pressure wound therapy and non-negative-pressure wound therapy (relative risk, 1.12; 95 percent CI, 0.66 to 1.89; p = 0.683).…”