Negative pressure wound therapy for patients with mediastinitis: A meta‐analysis

Wang, Zhi; Feng, Cheng; Wang, Xiaojun

doi:10.1111/iwj.13494

Cited by 6 publications

(6 citation statements)

References 21 publications

(37 reference statements)

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“…[20][21][22] A study indicated that VSD can shorten the time of the first skin graft. 23 Similarly, the results of this study showed that VSD can accelerate the growth of wound granulation tissue and reduce the time of the first skin graft. Continuous closure of VSD can draw out interstitial fluid from the wound, thereby reducing the pressure in blood vessels and improving blood circulation.…”

Section: Discussionsupporting

confidence: 61%

Clinical Application of Vacuum Sealing Drainage for the Treatment of Deep Burn Wounds

Sun

Ying

Wang

et al. 2021

The American Surgeon™

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Background This study aimed to determine the effect of the clinical application of vacuum sealing drainage (VSD) on the treatment of deep burn wounds. Methods This single-blind, randomized, controlled study included patients who were admitted to our hospital with deep burns from January 2018 to December 2020; the patients were randomly divided into the VSD and control (CON) groups. The number of days from treatment to skin grafting; survival rate of the first skin graft; rate of positive bacterial culture; visual analog scale (VAS) pain score; and durations of wound healing, antibiotic drug use, and hospitalization were analyzed and compared between the groups. Results The application of VSD significantly shortened the number of days from treatment to skin grafting ( P < .05); improved the survival rate of the first skin graft in patients with severe burns ( P < .05); reduced the rate of positive bacterial culture ( P < .05); reduced the VAS pain score ( P < .05); and shortened the durations of wound healing ( P < .05), antibiotic drug use ( P < .05), and hospitalization ( P < .05). Conclusion Vacuum sealing drainage had a good clinical effect on the recovery of deep burn wounds.

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Section: Discussionsupporting

confidence: 61%

Clinical Application of Vacuum Sealing Drainage for the Treatment of Deep Burn Wounds

Sun

Ying

Wang

et al. 2021

The American Surgeon™

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“…When the tissue is damaged or infected by toxins or bacteria, damaged by heat or other causes, it will enter the normal state of self-protection and damage repair. Therefore, IR is also a defensive response of human body to stimuli [ 23 , 24 ]. It was found that IR score in the Exp group was much lower than that in the Ctrl group at week 1 and 2 after treatment, and the difference was statistically significant ( p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Clinical evaluation of continuous irrigation with Bikerui combined with negative pressure closed drainage and platelet-rich plasma technique for treatment of stage III–IV pressure ulcer

Liu,

Chen

2024

pdia

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Introduction As a catastrophic complication of bedridden and elderly patients, pressure ulcer usually continuously affects patients’ health and quality of life, so the daily care of wounds is attached great importance in clinic. Aim This work investigated the effect of Bikerui disinfectant + vacuum sealing drainage (VSD) + platelet-rich plasma (PRP) therapy on patients with stage III ~ IV pressure sore. Material and methods In this work, 110 patients with pressure ulcer (PU) treated in our hospital were enrolled and were randomly divided into an experimental group (Exp group) and a control group (Ctrl group) by a blind selection method, with 55 cases in each group. Patients in the Ctrl group received surgical debridement + VSD for treatment, while those in the Exp group were treated with Bikerui disinfectant + VSD + PRP. Inflammatory response (IR) score, PU healing (PUH) score, healing time, dressing change frequency (DCF), dressing interval time (DIT), and scar recovery (SR) score of patients in different groups were compared. Results The results revealed that the positive rate of bacterial culture in wound secretions in the Exp group was greatly lower than that in the Ctrl group 1 or 2 weeks after treatment ( p < 0.05). The IR score in the Exp group was much lower at week 1 and 2 after treatment ( p < 0.05). The total effective rate (TER) in the Exp group was obviously higher than that in the Ctrl group (94.55% vs. 76.36%). Conclusions The results suggested that Bikerui disinfectant + VSD + PRP therapy could effectively improve the inflammatory degree of PU patients, promote the wound repair and scar recovery of patients, and greatly improve the clinical efficacy of PU patients.

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“…The distinctiveness and clinical relevance of our research lie in its detailed investigation and analysis of factors contributing to PWIs in lung cancer surgery. By employing both univariate and multivariate analyses, our study offers a comprehensive view of the complex interplay between various clinical and patient‐specific factors 21,22 …”

Section: Discussionmentioning

confidence: 99%

Comprehensive assessment of risk factors and pathogenic characteristics of wound infections following thoracoscopic radical resection for lung cancer

Xu,

Zhu

2024

International Wound Journal

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Lung cancer remains a leading cause of cancer‐related mortality, with surgical resection as a primary treatment modality. However, postoperative wound infections (PWIs) pose significant risks following thoracoscopic radical resection. This study aims to identify the risk factors and pathogenetic characteristics associated with PWIs in lung cancer surgery. A comprehensive retrospective study was conducted from August 2021 to June 2023 at our institution. The study included 30 patients who developed PWIs and 60 controls who did not, following thoracoscopic radical resection for lung cancer. We evaluated various factors including age, hospital stay, intraoperative blood loss, body mass index (BMI), operation time, prophylactic antibiotic use, diabetes mellitus and tumour staging. Diagnostic criteria for PWIs were based on clinical signs and microbiological confirmation. Statistical analysis was performed using SPSS software, utilizing chi‐square tests, and univariate and multivariate logistic regression analyses. The predominant pathogens identified in PWIs were Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Univariate analysis revealed operation time (≥4 h) and diabetes mellitus as significant risk factors for PWIs, while prophylactic antibiotic use was associated with a lower incidence of PWIs. Multivariate analysis further confirmed these findings, highlighting prolonged operation time and diabetes as significant predictors of PWIs, and antibiotic use as a protective factor. Prolonged operation time and diabetes mellitus significantly increase the risk of PWIs following thoracoscopic radical resection for lung cancer, whereas prophylactic antibiotics play a protective role. These findings underscore the importance of tailored preventive strategies in clinical practice to minimize the occurrence of postoperative infections and improve surgical outcomes in lung cancer patients.

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Negative pressure wound therapy for patients with mediastinitis: A meta‐analysis

Cited by 6 publications

References 21 publications

Clinical Application of Vacuum Sealing Drainage for the Treatment of Deep Burn Wounds

Clinical Application of Vacuum Sealing Drainage for the Treatment of Deep Burn Wounds

Clinical evaluation of continuous irrigation with Bikerui combined with negative pressure closed drainage and platelet-rich plasma technique for treatment of stage III–IV pressure ulcer

Comprehensive assessment of risk factors and pathogenic characteristics of wound infections following thoracoscopic radical resection for lung cancer

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