Negative predictors of clinical response to triptans in patients with migraine

Ishii, Masakazu; Sakairi, Yuki; Hara, Hajime; Imagawa, Atsuko; Shimizu, Shunichi; Takahashi, Joji; Nagamine, Ayumu; Naito, Yohei; Masuda, Yutaka; Usami, Shino; Kiuchi, Yuji

doi:10.1007/s10072-011-0716-z

Cited by 21 publications

(27 citation statements)

References 39 publications

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“…[36] The rs6276 G allele is also in high linkage disequilibrium (r 2 =0.95) with the rs6275 T allele (NcoI or C939T) which is associated with increased risk of schizophrenia, increase in prolactin in olanzapine-treated women, and response to treatment regimens for migraines. [22, 37-39] SNPs rs4648318 and rs4586205 are located in an intronic sequence in DRD2 ; variations in these non-coding regions are known to regulate expression of protein splice variants or affect protein levels. [40] Although rs4648318 has been weakly associated with nicotine dependence and Tourette syndrome[23, 41] little is known of the functional effect of this SNP.…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms in the Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision

Qadri

Bortsov

Orrey

et al. 2015

The Clinical Journal of Pain

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Objectives: Dopaminergic signaling is implicated in nociceptive pathways. These effects are mediated largely through dopamine receptors and modulated in part by dopamine transporters. This study tests the hypothesis that genetic variants in the genes encoding dopamine receptor 2 (DRD2) and the dopamine active transporter (SLC6A3) influence acute pain severity after motor vehicle collision (MVC). Methods: European Americans presenting to the emergency department (ED) after MVC were recruited. Overall pain intensity in ED was assessed using a 0-10 numeric rating scale. DNA was extracted from blood samples and genotyping of single nucleotide polymorphisms (SNPs) in the DRD2 and SLC6A3 gene was performed. Results: A total of 948 patients completed evaluation. After correction for multiple comparisons, SNP rs6276 at DRD2 showed significant association with pain scores, with individuals with the A/A genotype reporting lower mean pain scores (5.3, 95% CI 5.1 to 5.5) than those with A/G (5.9, 95% CI 5.6 to 6.1) or G/G (5.7, 95%CI 5.2 to 6.2) genotypes (p=0.0027). Secondary analyses revealed an interaction between sex and DRD2 SNPs rs4586205 and rs4648318 on pain scores: females with two minor alleles had increased pain intensity, whereas males with two minor alleles had less pain than individuals with a major allele (interaction p=0.0019). Discussion: Genetic variants in DRD2 are associated with acute pain after a traumatic stressful event. These results suggest that dopaminergic agents may be useful for the treatment of individuals with acute post-traumatic pain as part of a multimodal opioid-sparing analgesic regimen.

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Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms in the Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision

Qadri

Bortsov

Orrey

et al. 2015

The Clinical Journal of Pain

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“…Clinical responses to triptans were determined according to the responses of the responders and nonresponders. Responders treated with triptans were defined as those with diminished pain described as either “mild” (within 4 h of oral or nasal administration) or “none” (within 2 h of oral or nasal administration) in at least 2/3 attacks . Patients whose pain was not alleviated in the three consecutively treated migraine attacks were defined as nonresponders.…”

Section: Methodsmentioning

confidence: 99%

“…Migraine is the most common neurological condition, affecting approximately 8.4% of the general population in Japan . Migraines are typically characterized by severe unilateral or bilateral head pain and are often associated with impaired quality of life, adversely affecting daily activity, and work‐related productivity in many patients . Drug therapy for migraines falls into two categories: acute and preventive.…”

Section: Introductionmentioning

confidence: 99%

Negative predictors of clinical response to amitriptyline in Japanese patients with migraine

Naito

Ishii

Ishibashi

et al. 2018

Neurology & Clinical Neurosc

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Background Migraine is the most common neurological disease. Recently, there is a wide variety of prophylactic drugs, but their effects differ among individuals. Aim To investigate clinical factors affecting the response to amitriptyline therapy and establish a scoring system for predicting the negative response to prophylactic therapy. Methods We examined clinical factors from medical records of 29 consistent responders (CRs) and 21 inconsistent responders (IRs) to amitriptyline. Results Multivariate analysis revealed that a past history of medication overuse headache (MOH) and allodynia from associated symptoms were significant factors that independently contributed to a negative response. Odds ratio of MOH was 4.489 (no vs yes; 95% CI = 1.109–14.224), and odds ratio of allodynia was 4.489 (yes vs no; 95% CI = 1.109–14.224). A predictive index (PI) of the negative response to amitriptyline in patients with migraine was calculated using the regression coefficients of these two factors as integers, and the index was significantly higher for IRs than CRs (1.33 ± 0.58 vs 0.76 ± 0.69, mean ± SD, P = 0.003) Conclusion The obtained PI may represent an appropriate scoring system for negative responses in patients using amitriptyline.

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“…Responders were defined as those in whom an improvement in pain described as either ‘mild' (within 4 h of oral or nasal administration of triptans) or ‘none' (within 2 h of oral or nasal administration of triptans) in at least two out of three attacks [8]. Patients who were not pain-free in all the three consecutively treated migraine attacks were defined as non-responders.…”

Section: Methodsmentioning

confidence: 99%

“…Moderate to severe migraine attacks are treated with triptans, which are serotonin 1B/1D (5-HT 1B/1D ) agonists [8]. However, prophylactic drugs should be considered when such attacks are frequent or severe and when acute medication with triptans or non-steroidal anti-inflammatory drugs is ineffective.…”

Section: Introductionmentioning

confidence: 99%

Influence of the Tohoku-Pacific Ocean Earthquake and Its Aftershocks on the Response to Prophylactic Therapy with Lomerizine in Patients with Migraine in Tokyo: A Retrospective Study

Ishii¹,

Katoh²,

Takagi³

et al. 2014

Eur Neurol

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Background: On March 11, 2011, the Tohoku-Pacific Ocean earthquake (magnitude 9.0) struck the eastern part of Japan. Despite being far from the epicenter of the catastrophic earthquake, the effects were strongly felt in Tokyo, and the aftershocks continued for several months. There are no reports regarding the influence of earthquakes on migraine medication. The aim of our study was to determine the impact of earthquakes on prophylactic therapy with lomerizine in patients with migraine in Tokyo. Methods: The study included patients with migraine who were admitted to outpatient clinics in Tokyo between January 2010 and July 2010 or between January 2011 and July 2011 and who were prescribed lomerizine prophylactically for headache by specialists. We investigated clinical factors from the medical records for 26 of these patients. Results: The study population included 10 patients in 2010 and 16 patients in 2011. The frequency of headaches was reduced to under 5 days/month during February in both the groups. Compared to 2010, the frequency of headaches significantly increased in 2011 in March, April and May. Conclusion: Patients with migraine were sensitive to exposure to the earthquake and their headaches worsened despite successful prophylactic treatment with lomerizine before the Tohoku-Pacific Ocean earthquake.

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Negative predictors of clinical response to triptans in patients with migraine

Cited by 21 publications

References 39 publications

Genetic Polymorphisms in the Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision

Genetic Polymorphisms in the Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision

Negative predictors of clinical response to amitriptyline in Japanese patients with migraine

Influence of the Tohoku-Pacific Ocean Earthquake and Its Aftershocks on the Response to Prophylactic Therapy with Lomerizine in Patients with Migraine in Tokyo: A Retrospective Study

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