Negative Predictive Value of Preoperative Computed Tomography in Determining Pathologic Local Invasion, Nodal Disease, and Abdominal Metastases in Gastric Cancer

Kagedan, Daniel J.; Frankul, Fadi; El-Sedfy, Abraham; McGregor, Caitlin; Elmi, Maryam; Zagorski, Brandon; Dixon, Matthew; Mahar, Alyson; Vasilevska-Ristovska, Jovanka; Helyer, Lucy; Rowsell, Corwyn; Swallow, Carol J.; Law, Calvin; Coburn, Natalie

doi:10.3747/co.23.3124

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…High volume centres present contrasting numbers with negative prognostic value (NPV) of LN involvement at a level of 90.1% among patients with early GC [21,30]. However, in advanced GC Kagedan et al estimated NPV of LN metastases at 43.3%, emphasizing the issue of cN understaging [31]. On the other hand, Yamamoto et al investigated a correlation between the histological type of GC and accuracy of preoperative LN assessment: well-differentiated GC patients had more frequent overdiagnosis of LN involvement than undifferentiated GC (50% vs. 13.3%) [22].…”

Section: Computed Tomographymentioning

confidence: 99%

Lymph Node Involvement in Advanced Gastric Cancer in the Era of Multimodal Treatment—Oncological and Surgical Perspective

Pelc

Skórzewska

Rawicz‐Pruszyński

et al. 2021

Cancers

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Gastric cancer (GC) continues to be one of the major oncological challenges on a global scale. The role of neoadjuvant chemotherapy (NAC) in GC is to downstage primary tumour, eliminate potential micrometastases, and increase the chance for radical resection. Although systemic treatment prolongs the survival in advanced GC, persistent lymph node (LN) metastases indicate poor prognosis. Further identification of prognostic factors after NAC is urgent and could positively influence clinical outcomes. This article aimed to review the actual trends and future perspectives in multimodal therapy of advanced GC, with a particular interest in the post-neoadjuvant pathological nodal stage. A favourable prognostic impact for ypN0 patients is observed, either due to truly negative LN before the start of therapy or because preoperative therapy achieved a pathologically complete nodal response. Ongoing trials investigating the extent of lymphadenectomy after neoadjuvant therapy will standardise the LN dissection from the multimodal therapy perspective. Since downstaged and primarily node-negative patients show a similar prognosis, the main target for NAC in advanced GC should be nodal clearance. Adequate staging and personalised perioperative therapy seem to be of great importance in the multimodal treatment of GC.

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Section: Computed Tomographymentioning

confidence: 99%

Lymph Node Involvement in Advanced Gastric Cancer in the Era of Multimodal Treatment—Oncological and Surgical Perspective

Pelc

Skórzewska

Rawicz‐Pruszyński

et al. 2021

Cancers

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“…A current study reviewing 2,414 gastric cancer patients in 116 Canadian institutions categorized 450 patients as "negative nodal status" by CT; these patients underwent resection with curative intent and were actually found to be nodal positive. Thus, the negative predictive value was actually only 43.3% for nodal involvement (13). This means that CT could not detect 56.7% of patients with regional lymph node metastasis.…”

Section: Computed Tomography (Ct)mentioning

confidence: 92%

Preoperative staging of nodal status in gastric cancer

Berlth

Chevallay

Jung

et al. 2017

Transl. Gastroenterol. Hepatol.

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An accurate preoperative staging of nodal status is crucial in gastric cancer, because it has a great impact on prognosis and therapeutic decision-making. Different staging methods have been evaluated for gastric cancer in order to predict nodal involvement. So far, no technique could meet the necessary requirements, which include a high detection rate of infiltrated lymph nodes and a low frequency of falsepositive results. This article summarizes different staging methods used to assess lymph node status in patients with gastric cancer, evaluates the evidence, and proposes to establish new methods.

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Endoscopic Ultrasound in Esophageal and Gastric Cancer

Holt¹

2019

Endosonography

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Negative Predictive Value of Preoperative Computed Tomography in Determining Pathologic Local Invasion, Nodal Disease, and Abdominal Metastases in Gastric Cancer

Abstract: Background Before undergoing curative-intent resection of gastric adenocarcinoma (ga), most patients undergo

Cited by 3 publications

References 25 publications

Lymph Node Involvement in Advanced Gastric Cancer in the Era of Multimodal Treatment—Oncological and Surgical Perspective

Lymph Node Involvement in Advanced Gastric Cancer in the Era of Multimodal Treatment—Oncological and Surgical Perspective

Preoperative staging of nodal status in gastric cancer

Endoscopic Ultrasound in Esophageal and Gastric Cancer

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