Negative Predictive Value of Biparametric Prostate Magnetic Resonance Imaging in Excluding Significant Prostate Cancer: A Pooled Data Analysis Based on Clinical Data from Four Prospective, Registered Studies

Knaapila, Juha; Jambor, Ivan; Ettala, Otto; Taimen, Pekka; Verho, Janne; Perez, Ileana Montoya; Kiviniemi, Aida; Pahikkala, Tapio; Merisaari, Harri; Lamminen, Tarja; Saunavaara, Jani; Aronen, Hannu J.; Syvänen, Kari; Boström, Peter J.

doi:10.1016/j.euf.2020.04.007

Cited by 10 publications

(6 citation statements)

References 28 publications

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“…Recently, Christophe et al 66 investigated on the applicability of non‐contrast MRI as staging tool for prostate cancer and did not show any reduction in local staging accuracy. Several systematic reviews and meta‐analysis have been published on the topic 67‐74 . In 2018, Woo et al 71 selected 20 studies with 2142 patients.…”

Section: The Role Of Contrast and Non‐contrast‐enhanced Mrimentioning

confidence: 99%

“…Several systematic reviews and meta-analysis have been published on the topic. [67][68][69][70][71][72][73][74] In 2018, Woo et al 71 67 published a pooled data analysis on the NPV of bpMRI based on clinical data from four prospective studies and showed NPVs of bpMRI Likert scores 3-5 and 4-5 for csPCa were 0.932 and 0.909, respectively, and the corresponding PPV were 0.589 and 0.720.…”

Section: Evidence In Literature On Non-contrast Mri Performancementioning

confidence: 99%

“…No difference was revealed in the pooled diagnostic estimates between bpMRI and mpMRI. Finally, Knaapila et al 67 published a pooled data analysis on the NPV of bpMRI based on clinical data from four prospective studies and showed NPVs of bpMRI Likert scores 3–5 and 4–5 for csPCa were 0.932 and 0.909, respectively, and the corresponding PPV were 0.589 and 0.720.…”

Section: The Role Of Contrast and Non‐contrast‐enhanced Mrimentioning

confidence: 99%

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The future direction of imaging in prostate cancer: MRI with or without contrast injection

et al. 2021

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Background: Multiparametric MRI (mpMRI) is the "state of the art" management tool for patients with suspicion of prostate cancer (PCa). The role of non-contrast MRI is investigated to move toward a more personalized, less invasive, and highly costeffective PCa diagnostic workup.Objective: To perform a non-systematic review of the existing literature to highlight strength and flaws of performing non-contrast MRI, and to provide a critical overview of the international scientific production on the topic. Materials and Methods:Online databases (Medline, PubMed, and Web of Science) were searched for original articles, systematic review and meta-analysis, and expert opinion papers.Results: Several investigations have shown comparable diagnostic accuracy of biparametric (bpMRI) and mpMRI for the detection of PCa. The advantage of abandoning contrast-enhanced sequences improves operational logistics, lowering costs, acquisition time, and side effects. The main limitations of bpMRI are that most studies comparing non-contrast with contrast MRI come from centers with high expertise that might not be reproducible in the general community setting; besides, reduced protocols might be insufficient for estimation of the intra-and extra-prostatic extension and regional disease. The mentioned observations suggest that low-quality mpMRI for the general population might represent the main shortage to overcome.Discussion: Non-contrast MRI future trends are likely represented by PCa screening and the application of artificial intelligence (AI) tools. PCa screening is still a controversial topic; bpMRI has become one of the most promising diagnostic applications, as it is a more sensitive test for PCa early detection, compared to serum PSA level test. Also, AI applications and radiomic have been the object of several studies investigating PCa detection using bpMRI, showing encouraging results. Conclusion:Today, the accessibility to MRI for early detection of PCa is a priority.Results from prospective, multicenter, multireader, and paired validation studies are needed to provide evidence supporting its role in the clinical practice.

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Section: The Role Of Contrast and Non‐contrast‐enhanced Mrimentioning

confidence: 99%

Section: Evidence In Literature On Non-contrast Mri Performancementioning

confidence: 99%

Section: The Role Of Contrast and Non‐contrast‐enhanced Mrimentioning

confidence: 99%

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The future direction of imaging in prostate cancer: MRI with or without contrast injection

et al. 2021

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“…14–17 The IMPROD bpMRI (Figure 1) protocol was developed in 2012–2013 before the start of the IMPROD trial (NCT01864135) and free public access to the imaging datasets and protocol is provided at http://petiv.utu.fi/improd/and http://petiv.utu.fi/multiimprod / . These study servers provide centres with little experience with prostate MRI a unique opportunity to import with minimal modifications a standardized fast acquisition protocol of prostate MRI performed without the use of intra-venous contrast agents, 18 developed and validated in prospective clinical trial settings. Additionally, IMPROD and MULTI-IMPROD servers (http://petiv.utu.fi/improd/and http://petiv.utu.fi/multiimprod / ) are freely publicly accessible and offer the unique opportunity to function as a learning place with further standardization of MRI reporting systems.…”

Section: Where To Start: Access To Prostate Mri Acquisition Protocol and Imaging Datasetsmentioning

confidence: 99%

How to read biparametric MRI in men with a clinical suspicious of prostate cancer: Pictorial review for beginners with public access to imaging, clinical and histopathological database

Jambor

Martini

Falagario

et al. 2021

Acta Radiologica Open

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Prostate Magnetic Resonance Imaging (MRI) is increasingly being used in men with a clinical suspicion of prostate cancer (PCa). Performing prostate MRI without the use of an intravenous contrast (IV) agent in men with a clinical suspicion of PCa can lead to reduced MRI scan time. Enabling a large array of different medical providers (from mid-level to specialized radiologists) to evaluate and potentially report prostate MRI in men with a clinical suspicion of PCa with a high accuracy could be one way to enable wide adoption of prostate MRI in men with a clinical suspicion of PCa. The aim of this pictorial review is to provide an insight into acquisition, quality control and reporting of prostate MRI performed without IV contrast agent in men with a clinical suspicion of PCa, aimed specifically at radiologists starting reporting prostate MRI, urologists, urology/radiology residents and mid-level medical providers without experience in reporting prostate MRI. Free public access ( http://petiv.utu.fi/improd/ and http://petiv.utu.fi/multiimprod/ ) to complete datasets of 161 and 338 men is provided. The imaging datasets are accompanied by clinical, laboratory and histopathological findings. Several topics are simplified in order to provide a solid base for the development of skills needed for an unsupervised review and potential reporting of prostate MRI in men with a clinical suspicion of PCa. The current review represents the first step towards enabling a large array of different medical providers to review and report accurately prostate MRI performed without IV contrast agent in men with a clinical suspicion of PCa.

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“…However, in the landmark papers, not even half of PI-RADS 4 lesions include significant PCa. [6][7][8] Additionally, PI-RADS 3 lesions include significant PCa in about 10%-20% of cases. This distribution is also roughly present in the current study.…”

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confidence: 99%

Editorial for “Biparametric Magnetic Resonance Imaging‐Derived Nomogram to Detect Clinically Significant Prostate Cancer by Targeted Biopsy for Index Lesion”

Negative Predictive Value of Biparametric Prostate Magnetic Resonance Imaging in Excluding Significant Prostate Cancer: A Pooled Data Analysis Based on Clinical Data from Four Prospective, Registered Studies

Cited by 10 publications

References 28 publications

The future direction of imaging in prostate cancer: MRI with or without contrast injection

The future direction of imaging in prostate cancer: MRI with or without contrast injection

How to read biparametric MRI in men with a clinical suspicious of prostate cancer: Pictorial review for beginners with public access to imaging, clinical and histopathological database

Editorial for “Biparametric Magnetic Resonance Imaging‐Derived Nomogram to Detect Clinically Significant Prostate Cancer by Targeted Biopsy for Index Lesion”

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