“…However, large-scale crop monoculture results in many problems including a loss of crop genetic diversity, an increase in disease incidence, a decline in crop quality and even the fragility of ecosystem functioning (Jacques and Jacques, 2012;Mariotte et al, 2018;. Consecutive monoculture problems, also known as replant problems or replant disease, are especially severe in the cultivation of medicinal herbs, such as Rehmannia glutinosa, Panax notoginseng, Pseudostellaria heterophylla, and Panax ginseng (Dong et al, 2018a;Luo et al, 2019;Wu et al, 2019;Zhang et al, 2019). It was reported that approximately 70% of medicinal herbs using tuberous roots were attacked by replant disease (Wu et al, 2016c).…”