Negative pigment network: An additional dermoscopic feature for the diagnosis of melanoma

Pizzichetta, Maria Antonietta; Talamini, Renato; Marghoob, Ashfaq; Soyer, H. Peter; Argenziano, Giuseppe; Bono, R.; Corradin, Maria Teresa; Giorgi, Vincenzo De; Gonzalez, Marian A.; Kolm, Isabel; Kopf, A; Malvehy, Josep; Nami, Niccolò; Oliviero, Margaret; Pellacani, Giovanni; Puig, Susana; Rabinovitz, Harold; Rubegni, Pietro; Seidenari, Stefania; Stanganelli, Ignazio; Veronesi, Andrea; Zalaudek, Iris; Zampieri, Pierfrancesco; Menzies, Scott W.

doi:10.1016/j.jaad.2012.08.012

Cited by 49 publications

(31 citation statements)

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“…A collection of 182 dermoscopic images of melanomas from the University of Miami Melanoma Program and Plantation Cutaneous and Surgery Clinic from 2000 to 2011 were reviewed by 3 of us (M.I.S., H.S.R., and J.M.G.). Primary cutaneous melanomas with similar dermoscopic features were grouped together based on dermoscopy features from Argenziano et al, 9 Pizzichetta et al, 10 Keir, 11 and our own experience. At least 10 different primary dermoscopic growth patterns were noted, including disorganized fine network, 9 epidermal crease sparing, gray-dotted regression, , and dark homogeneous streaks pattern ( Figure 3).…”

Section: Study Setmentioning

confidence: 99%

Dark Homogeneous Streak Dermoscopic Pattern Correlating With SpecificKITMutations in Melanoma

et al. 2014

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Dark Homogeneous Streak Dermoscopic Pattern Correlating With SpecificKITMutations in Melanoma

et al. 2014

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“…In a recent review assessing the frequency and characteristics of NPN in a population of melanomas. Spitz naevi and non-melanocytic lesions, Pizzichetta et al (19) observed that this dermoscopic feature is more frequent than previously described. Under polarized dermoscopy, so called chrysalis structures, have been reported to correspond to changes in the composition and orientation of collagen stroma in melanoma (20).…”

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confidence: 79%

“…NPN has been described as a dermoscopic feature related to several cutaneous entities, such as dermatofibromas (19), Spitz naevi (27), dysplastic naevi and melanoma, mainly in its invasive subtype (14). Although in a recent study by Argenziano et al (26), NPN was not considered predictive for the final diagnosis of benign or malignant lesion and Menzies et al (14) and Skvara et al (7) reported a low sensitivity of NPN in MM diagnosis, the importance of NPN as a diagnostic clue for MM has been affirmed by others (19,28).…”

Section: Discussionmentioning

confidence: 99%

“…The evaluation of NPN distribution (central, peripheral, both) and lesion surface involvement (<20%, 20-50%, >50%) was also performed. Moreover, NPN was defmed as homogeneous when the width of the "cords" was uniform, and heterogeneous when an increased range of width of the ridges, surrounding globules varying in both shape and size, was noticed (19).…”

Section: Methodsmentioning

confidence: 99%

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Negative Pigment Network Identifies a Peculiar Melanoma Subtype and Represents a Clue to Melanoma Diagnosis: A Dermoscopic Study of 401 Melanomas

Bassoli¹,

Ferrari²,

Borsari³

et al. 2013

Acta Derm Venerol

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The dermoscopic descriptor "negative pigment network" (NPN) has been reported in several types of melanocytic and non-melanocytic lesions, although it has a higher frequency of association with melanoma and Spitz naevus. In a study of 401 consecutive melanomas, excluding facial, acral and mucosal locations, the frequency and variability of NPN were investigated, and the results of NPN correlated with clinical and histopathological data. NPN of any extension was found in 27% of melanomas, most frequently invasive and arising from a naevus on the trunk of young subjects. Seven percent of melanomas in the study population showed presence of NPN in more than half of the lesion area; most of these did not show typical dermoscopic melanoma features. The authors propose a new melanoma subtype, in which extensive NPN should be considered as a diagnostic indicator.

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“…da üst ekstremite ve alt ekstremite melanomlarında Breslow kalınlığı açısından bir fark olmadığını belirtmiştir 16 . 24 . Bu çalışmada negatif pigment ağı, melanomların %20'sinde mevcuttu.…”

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The clinical and dermoscopic features of extremity melanomas

Cengiz¹,

Emiroğlu²,

Hofmann‐Wellenhof³

2015

TURKDERM

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Background and Design:Dermoscopy is a noninvasive tool that helps differentiate structures that cannot be seen by naked eye. Dermoscopic and clinical features of malignant melanomas of the extremities are not well described in the literature. Therefore, in this study, we aimed to determine the dermoscopic and clinical characteristics of melanoma of the extremities. Materials and Methods: 40 patients with melanoma of the extremities were included in this study. Their dermoscopic and clinical images, histopathological and clinical data were assessed. The relationships between Breslow thickness and dermoscopic characteristics were evaluated. Results: The most frequent localization in women was the lower extremities, whereas it was the upper extremities in men. The most common subtype of melanoma was superficial spreading melanoma of the extremities. The mean age of the males and females was 56.21±15.20 and 53.09±13.96, respectively. The most common dermoscopic feature of extremity melanoma was irregular dots (85%). Breslow thickness positively correlated with diameter of the lesion, presence of 3 or more colors in lesion, blue-white veil feature and linear white streaks (p<0. 005, r=+0.462; p<0.001, r=+0.550; p<0.001, r=+0.606; p<0.001, r=+0.662, respectively). Conclusion: To our knowledge, this is the first study investigating the dermoscopic and clinical features in patients with extremity melanomas. We suggest that melanomas of the lower extremities are more common in women than in men and patients with lower extremity melanomas

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Negative pigment network: An additional dermoscopic feature for the diagnosis of melanoma

Cited by 49 publications

References 18 publications

Dark Homogeneous Streak Dermoscopic Pattern Correlating With SpecificKITMutations in Melanoma

Dark Homogeneous Streak Dermoscopic Pattern Correlating With SpecificKITMutations in Melanoma

Negative Pigment Network Identifies a Peculiar Melanoma Subtype and Represents a Clue to Melanoma Diagnosis: A Dermoscopic Study of 401 Melanomas

The clinical and dermoscopic features of extremity melanomas

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