Negative‐ion fast atom bombardment mass spectra of some bisanionic hypervalent germanium, silicon and titanium salts

Abstract

Negative-ion fast atom bombardment mass spectra of hypervalent germanates, silicates and titanate with the use of two matrices, glycerol and m-nitrobenzyl alcohol, were studied. In the case of germanates a complete reaction of the studied anion with glycerol is observed, so it is impossible to use such a matrix to identify these compounds. The use of m-nitrobenzyl alcohol allows spectra to be obtained that are significant with respect to the structure for all the studied compounds. However, for each compound a partial reaction of this matrix is observed. Further, in the case of doubly charged anions, the adduct ion obtained with an alkali metal cation does not show glycerol reactivity whereas such reactivity occurs from the adduct ion obtained with proton.

Electrospray ionization mass spectrometry of organogermanium compounds

“…However, the low solubility and volatility of many organogermanium compounds may hinder attempts to measure them using classical MS methods. There are a few successful cases of structural detection of organogermanium compounds with conventional MS techniques, e.g., electron impact (EI),7–11 chemical ionization (CI),12 desorption chemical ionization (DCI),12 and fast atom bombardment (FAB) 12–16. A seldom used negative ion MS method, resonance electron capture (REC) ionization, has also been applied to the structural identification of three biscarboxyalkylgermanium dihydroxides 17.…”

Determination of oxyntomodulin, an anorectic polypeptide, in rat plasma using 2D-LC–MS/MS coupled with ion pair chromatography

“…It has been observed that incorporation of modifiers into reverse phase chromatography may improve sensitivity and resolution for intact proteins [29]. Traditionally, 3-NBA (C 7 H 7 NO 3 ), with a pK a of 13.82, has been used as a matrix for fast atom bombardment and matrix assisted laser desorption ionization (MALDI) [30,31]. Following optimization of SRM transitions, it was observed that signal intensity improved more than an order of magnitude in the presence of 3-nitrobenzyl alcohol (3-NBA) in the solvent mixture.…”