Negative Inotropic and Chronotropic Effects of Phenolic Fraction from &lt;i&gt;Cynodon dactylon&lt;/i&gt; (linn) on Isolated Perfused Frog Heart

Shabi, Mohamed M.; Chellappan, David Raj; Sasikala, C.; Gayathri, K.; Joseph, Jipnomon

doi:10.3329/jsr.v4i3.8549

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Aleppo pine [10] Mediterranean, Southern Europe, Asia, and North Africa [70] Pulsatilla pratensis [68] Sub-polar areas of Europe, Asia, North America Central, and Eastern Europe [71] Triangular distribution A root taproot system with small lateral roots Trigonella balansae [68] Europe, and Asia [72] Parabolic distribution A concentrated root system Cynodon dactylon [69] North Africa, Asia, Australia, and Southern Europe [73] Exponential distribution A plate-shaped root system Beech and Mature oaks [10] Europe, and North America [74,75] Root biomass can be expressed by root volume, mass, area, or length, and the most commonly adopted measure is the soil area occupied by the roots [76]. In order to achieve a fair comparison, the symmetric parts of the four root architecture profiles are normalised to the same unit area.…”

Section: Root Architectures Characteristics Typical Species Growing R...mentioning

confidence: 99%

Numerical Analysis of an Explicit Smoothed Particle Finite Element Method on Shallow Vegetated Slope Stability with Different Root Architectures

Jia

Zhang

Wang³

et al. 2022

Sustainability

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Planting vegetation is an environmentally friendly method for reducing landslides. Current vegetated slope analysis fails to consider the influence of different root architectures, and the accuracy and effectiveness of the numerical simulations need to be improved. In this study, an explicit smoothed particle finite element method (eSPFEM) was used to evaluate slope stability under the influence of vegetation roots. The Mohr–Coulomb constitutive model was extended by incorporating apparent root cohesion into the shear strength of the soil. The slope factors of safety (FOS) of four root architectures (uniform, triangular, parabolic, and exponential) for various planting distances, root depths, slope angles, and planting locations were calculated using the shear strength reduction technique with a kinetic energy-based criterion. The results indicated that the higher the planting density, the stronger the reinforcement effect of the roots on the slope. With increasing root depth, the FOS value first decreased and then increased. The FOS value decreased with an increase in slope angle. Planting on the entire ground surface had the best improvement effect on the slope stability, followed by planting vegetation with a uniform root architecture in the upper slope region or planting vegetation with triangular or exponential root architecture on the slope’s toe. Our findings are expected to deepen our understanding of the contributions of different root architectures to vegetated slope protection and guide the selection of vegetation species and planting locations.

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Section: Root Architectures Characteristics Typical Species Growing R...mentioning

confidence: 99%

Numerical Analysis of an Explicit Smoothed Particle Finite Element Method on Shallow Vegetated Slope Stability with Different Root Architectures

Jia

Zhang

Wang³

et al. 2022

Sustainability

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“…5 Shabi et al showed negative inotropic and chronotropic actions of C. dactylon on isolated frog heart. 13 The results of another study that investigated the effects of different fractions of hydroalcoholic extract of C. dactylon on heart failure showed that the methanolic fraction of C. dactylon obtained by 40 and 60% methanol -Cynodon dactylon had the strongest inotropic effect. 14 Najafi et al demonstrated that the hydroalcoholic extract of C. dactylon reduces myocardial infarct size and arrhythmias following isolated heart ischemia/ reperfusion.…”

Section: Introductionmentioning

confidence: 99%

Hydroalcoholic Extract from Rhizomes of Cynodon dactylon Improve Hemodynamic and Electrocardiogram Parameters in Myocardial Infarction in Rats

et al. 2019

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Background: Cynodon dactylon is a herbal medicine of interest in Iranian traditional medicine, which is used in cardiovascular diseases such as atherosclerosis and heart failure. The purpose of this study was to evaluate the effects of total extract of C. dactylon rhizomes on myocardial infarction and on post myocardial infarction (MI) heart tissue injuries. Methods: Isoproterenol (100 mg/kg) was injected subcutaneously for two consecutive days for induction of MI in rats and C. dactylon extract was administered orally twice daily started before isoproterenol injection for 4 consecutive days. Results: Histopathological analysis showed a marked increase in myocardial necrosis in rats with MI (p<0.001). Treatment with C. dactylon (200 mg/kg) significantly (P<0.05) decreased myocardial necrosis. Hemodynamic variables were significantly suppressed in MI group and treatment with C. dactylon improved the hemodynamic parameters (P<0.05). Our electrocardiogram analysis demonstrated that C. dactylon with all doses increased R-Amplitude and R-R Interval (p<0.05, p<0.01) which were suppressed in MI group. Furthermore in treated groups with 100 and 200 mg/kg, P-R interval was also significantly increased in compared to MI group. Conclusion: This study demonstrated that C. dactylon can improve hemodynamic and electrocardiogram parameters in isoproterenol-induced myocardial infarction and thereby suggest that it can be used as a cardioprotective agent in myocardial infarction.

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Angiogenic effect of the aqueous extract of Cynodon dactylon on human umbilical vein endothelial cells and granulation tissue in rat

et al. 2015

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BackgroundCynodon dactylon, a valuable medicinal plant, is widely used in Iranian folk medicine for the treatment of various cardiovascular diseases such as heart failure and atherosclerosis. Moreover, its anti-diabetic, anti-cancer and anti-microbial properties have been also reported. Concerning the critical role of angiogenesis in the incidence and progression of tumors and also its protective role in cardiovascular diseases, we investigated the effects of the aqueous extract prepared from the rhizomes of C. dactylon on vascular endothelial growth factor (VEGF) expressions in Human Umbilical Vein Endothelial Cells (HUVECs) and also on angiogenesis in carrageenan induced air-pouch model in rats.MethodsIn the air-pouch model, carrageenan was injected into an air-pouch on the back of the rats and following an IV injection of carmine red dye on day 6, granulation tissue was processed for the assessment of the dye content. Furthermore, in an in vitro study, angiogenic property of the extract was assessed through its effect on VEGF expression in HUVECs.ResultsOral administration of 400 mg/kg/day of the extract significantly increased angiogenesis (p < 0.05) and markedly decreased neutrophil (p < 0.05) and total leukocyte infiltration (p < 0.001) into the granulation tissues. Moreover, the extract increased the expression of total VEGF in HUVECs at a concentration of (100 μl/ml).ConclusionThe present study showed that the aqueous extract of C. dactylon promotes angiogenesis probably through stimulating VEGF expression.

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Negative Inotropic and Chronotropic Effects of Phenolic Fraction from <i>Cynodon dactylon</i> (linn) on Isolated Perfused Frog Heart

Cited by 4 publications

References 18 publications

Numerical Analysis of an Explicit Smoothed Particle Finite Element Method on Shallow Vegetated Slope Stability with Different Root Architectures

Numerical Analysis of an Explicit Smoothed Particle Finite Element Method on Shallow Vegetated Slope Stability with Different Root Architectures

Hydroalcoholic Extract from Rhizomes of Cynodon dactylon Improve Hemodynamic and Electrocardiogram Parameters in Myocardial Infarction in Rats

Angiogenic effect of the aqueous extract of Cynodon dactylon on human umbilical vein endothelial cells and granulation tissue in rat

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