Negative Indocyanine Green Staining of Epiretinal Membranes

Surgical Management of Epiretinal Membrane with Indocyanine-Green-Assisted Peeling

“…We have operated so far 53 cases of ERM with ICG staining (data not published). Our observations are: if the ERM is thin, the highly cellular ERM tends to stain negatively or irregularly by the ICG, in agreement with a previous study [12]. If the ERM is thick, a green color emerges possibly from an extracellular accumulation of ICG among the glial tissue of the ERM.…”

Visual Acuity after Vitrectomy and Epiretinal Membrane Peeling with or without Premacular Indocyanine Green Injection

“…In some cases of thick ERM, the dense center is fre q u e n t l y less intensely stained than the thinner peripheral part. This is most likely due to the fact that ICG selectively stains the acellular ILM, but not the cellular ERM (3,4,27). We could t h e re f o re assume that the cellular ERM acts as a pro t e ctive film between ICG and the macular re t i n a .…”

Safety Testing of Indocyanine Green and Trypan Blue Using Retinal Pigment Epithelium and Glial Cell Cultures

“…[1][2][3][4][5][6][7][8] By selectively staining ocular tissue, 8 -10 these agents make structures such as the inner limiting membrane (ILM) 1,3-6,8,10 -13 and epiretinal membranes 14 more evident to the surgeon. Although these chromophores are useful surgical tools, there has been a debate regarding the safety of ICG [11][12][13][15][16][17][18][19][20][21][22] and its effect on the retinal pigment epithelium (RPE).…”