Negative environmental impacts of antibiotic-contaminated effluents from pharmaceutical industries

Bielen, Ana; Šimatović, Ana; Kosić-Vukšić, Josipa; Senta, Ivan; Ahel, Marijan; Babić, Sanja; Jurina, Tamara; Plaza, Juan José González; Milaković, Milena; Udiković-Kolić, Nikolina

doi:10.1016/j.watres.2017.09.019

Cited by 277 publications

(100 citation statements)

References 46 publications

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“…Currently, although in-feed antibiotic, such as virginiamycin and tylosin, is the most effective approach for the control of C. perfringens infections in livestock and poultry, antibiotics can result in many negative effects on the environment as well as human health [14]. Parenteral vaccination with inactivated vaccines/subunit vaccines is usually effective in eliciting systemic immune responses, which could provide effective protection against many animal clostridial diseases [15].…”

Section: Introductionmentioning

confidence: 99%

An EGFP-marked recombinant lactobacillus oral tetravalent vaccine constitutively expressing α, ε, β1, and β2 toxoids for Clostridium perfringens elicits effective anti-toxins protective immunity

et al. 2019

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Clostridium perfringens is a common opportunistic pathogen endangering livestock and poultry breeds. Here, using enhanced green fluorescent protein as screening marker, a recombinant lactobacillus tetravalent vaccine constitutively expressing α, ϵ, β1, and β2 toxoids of C. perfringens was developed, and its immunogenicity in mice was investigated via oral administration. This probiotic vaccine could effectively induce antigen-specific secretory IgA (sIgA)-based mucosal and IgG-based humoral immune responses, and significantly high levels (p< 0.05) of cytokines IL-2, IL-4, IL-10, IL-12, IL-17, and IFN-γ were produced in immunized mice. Moreover, lymphoproliferation and percentage of CD4+ and CD8+ T cells significantly increased in mice of the probiotic vaccine group. Challenge experiments were performed in mice with C. perfringens toxinotypes A, C, and D crude toxins to evaluate protection efficiency of the probiotic vaccine, using a commercial inactivated C. perfringens vaccine made by C. perfringens toxinotypes A, C, and D as vaccine control. We observed 80% protection rate in the probiotic vaccine group, which was higher than commercial vaccine group, whereas all mice in control groups died and obvious histopathological changes were observed in liver, spleen, kidney, and intestines of mice. Significantly, we compared the immunogenicity and protection efficiency of lactobacillus constitutive expression system and lactobacillus inducible expression system, and results showed that lactobacillus constitutive expression system has obvious advantages. Our study clearly demonstrated that the probiotics vaccine could effectively induce mucosal, humoral, and cellular immunity, and provide effective protection against C. perfringens toxins, suggesting a promising strategy for the development of oral vaccine against C. perfringens.

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Section: Introductionmentioning

confidence: 99%

An EGFP-marked recombinant lactobacillus oral tetravalent vaccine constitutively expressing α, ε, β1, and β2 toxoids for Clostridium perfringens elicits effective anti-toxins protective immunity

et al. 2019

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“…The quality parameters of the raw wastewater are summarized in Table 1, which indicates that the wastewater discharged by the pharmaceutical industry holds high organic content, as COD and BOD concentrations were higher than the permissible limits and having BOD 5 /COD ratio lower than 0.4, which shows the low biodegradability of the targeted effluent [30]. However, the most significant compound detected is CIP, an antibiotic belong to the fluoroquinolone group.…”

Section: Quality Of Pharmaceutical Wastewatermentioning

confidence: 99%

Ozonation and Photo-Driven Oxidation of Ciprofloxacin in Pharmaceutical Wastewater: Degradation Kinetics and Energy Requirements

Wajahat¹,

Yasar²,

Khan³

et al. 2019

Pol. J. Environ. Stud.

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“…surface runoff). And then was uptake by the crops, which is toxic to primary producer and higher tropic level [16]. Ultimately, antibiotics even ARGs enter into human or animals' body through agriculture products.…”

Section: Roots Of Antibiotics' Vicious Cycle Though Aquatic Environmentmentioning

confidence: 99%

Roots of Antibiotic’s Vicious Cycle through Aquatic Environment

Liu¹

2017

BJSTR

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Negative environmental impacts of antibiotic-contaminated effluents from pharmaceutical industries

Cited by 277 publications

References 46 publications

An EGFP-marked recombinant lactobacillus oral tetravalent vaccine constitutively expressing α, ε, β1, and β2 toxoids for Clostridium perfringens elicits effective anti-toxins protective immunity

An EGFP-marked recombinant lactobacillus oral tetravalent vaccine constitutively expressing α, ε, β1, and β2 toxoids for Clostridium perfringens elicits effective anti-toxins protective immunity

Ozonation and Photo-Driven Oxidation of Ciprofloxacin in Pharmaceutical Wastewater: Degradation Kinetics and Energy Requirements

Roots of Antibiotic’s Vicious Cycle through Aquatic Environment

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