Negative effects of brain regulatory T cells depletion on epilepsy

Yue, Jiong; Xu, Ran; Chen, Yin; Yang, Hui; Zhang, Chunqing; Zhao, Deyu

doi:10.1016/j.pneurobio.2022.102335

Cited by 10 publications

(15 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings implied that Treg depletion promoted the development of a microglia‐mediated inflammatory environment after SCI. Similarly, recent studies have reported that Treg depletion almost completely abrogated the protective mechanisms against injury, through enabling TNFα, IL‐1β, IL‐6, and IL‐17 levels to increase rapidly 57 . Conversely, the expansion of brain‐resident Tregs protects against pathological neuroinflammation 58 .…”

Section: Discussionmentioning

confidence: 93%

Regulatory T cells promote functional recovery after spinal cord injury by alleviating microglia inflammation via STAT3 inhibition

Liu

Wang

et al. 2023

CNS Neurosci Ther

View full text Add to dashboard Cite

Spinal cord injury (SCI) often leads to permanent paraplegia; therefore, it represents a major global health priority. 1,2 Immediately following a spinal trauma, the breakdown of the blood-spinal cord barrier causes an influx of immune cells and proinflammatory cytokines, such as TNFα and IL-1β, into the spinal cord, which triggers an inflammatory cascade. 3 This inflammation eventually unbalances

show abstract

Section: Discussionmentioning

confidence: 93%

Regulatory T cells promote functional recovery after spinal cord injury by alleviating microglia inflammation via STAT3 inhibition

Liu

Wang

et al. 2023

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…The number of Tregs in the brain was negatively correlated with seizure frequency in patients with epilepsy ( 44 ). Depletion of intracerebral Tregs promoted astrocytosis, microglia, inflammatory cytokine production, oxidative stress and neuronal loss in the hippocampus after status epilepticus seizures ( 45 ). Modulation of Tregs in epileptic brain tissue has therapeutic potential.…”

Section: Discussionmentioning

confidence: 99%

Identification of hub genes significantly linked to tuberous sclerosis related-epilepsy and lipid metabolism via bioinformatics analysis

Weiliang,

Yinghao,

Weiliang

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

BackgroundTuberous sclerosis complex (TSC) is one of the most common genetic causes of epilepsy. Identifying differentially expressed lipid metabolism related genes (DELMRGs) is crucial for guiding treatment decisions.MethodsWe acquired tuberous sclerosis related epilepsy (TSE) datasets, GSE16969 and GSE62019. Differential expression analysis identified 1,421 differentially expressed genes (DEGs). Intersecting these with lipid metabolism related genes (LMRGs) yielded 103 DELMRGs. DELMRGs underwent enrichment analyses, biomarker selection, disease classification modeling, immune infiltration analysis, weighted gene co-expression network analysis (WGCNA) and AUCell analysis.ResultsIn TSE datasets, 103 DELMRGs were identified. Four diagnostic biomarkers (ALOX12B, CBS, CPT1C, and DAGLB) showed high accuracy for epilepsy diagnosis, with an AUC value of 0.9592. Significant differences (p < 0.05) in Plasma cells, T cells regulatory (Tregs), and Macrophages M2 were observed between diagnostic groups. Microglia cells were highly correlated with lipid metabolism functions.ConclusionsOur research unveiled potential DELMRGs (ALOX12B, CBS, CPT1C and DAGLB) in TSE, which may provide new ideas for studying the psathogenesis of epilepsy.

show abstract

“…In the development of TLE, the involvement of OS and neuroinflammation have been well established as important factors, in part because the large amount of energy required by the brain is considered to be a possible mechanism involved in epileptogenesis [ 12 , 21 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. In recent studies, it was observed that the specific inhibition of NADPH oxidase (NOX), the main producer of OS through O 2 •− synthesis, modified chronic epilepsy in a TLE rat model, preventing ROS generation, mitochondrial depolarization, and neuronal death.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antioxidant Activity of Levetiracetam in a Temporal Lobe Epilepsy Model

et al. 2023

View full text Add to dashboard Cite

Epilepsy is a neurological disorder in which it has been shown that the presence of oxidative stress (OS) is implicated in epileptogenesis. The literature has shown that some antiseizure drugs (ASD) have neuroprotective properties. Levetiracetam (LEV) is a drug commonly used as an ASD, and in some studies, it has been found to possess antioxidant properties. Because the antioxidant effects of LEV have not been demonstrated in the chronic phase of epilepsy, the objective of this study was to evaluate, for the first time, the effects of LEV on the oxidant–antioxidant status in the hippocampus of rats with temporal lobe epilepsy (TLE). The in vitro scavenging capacity of LEV was evaluated. LEV administration in rats with TLE significantly increased superoxide dismutase (SOD) activity, increased catalase (CAT) activity, but did not change glutathione peroxidase (GPx) activity, and significantly decreased glutathione reductase (GR) activity in comparison with epileptic rats. LEV administration in rats with TLE significantly reduced hydrogen peroxide (H2O2) levels but did not change lipoperoxidation and carbonylated protein levels in comparison with epileptic rats. In addition, LEV showed in vitro scavenging activity against hydroxyl radical (HO•). LEV showed significant antioxidant effects in relation to restoring the redox balance in the hippocampus of rats with TLE. In vitro, LEV demonstrated direct antioxidant activity against HO•.

show abstract

Negative effects of brain regulatory T cells depletion on epilepsy

Cited by 10 publications

References 66 publications

Regulatory T cells promote functional recovery after spinal cord injury by alleviating microglia inflammation via STAT3 inhibition

Regulatory T cells promote functional recovery after spinal cord injury by alleviating microglia inflammation via STAT3 inhibition

Identification of hub genes significantly linked to tuberous sclerosis related-epilepsy and lipid metabolism via bioinformatics analysis

Evaluation of the Antioxidant Activity of Levetiracetam in a Temporal Lobe Epilepsy Model

Contact Info

Product

Resources

About