Negative Effect of Immediate Hyperbaric Oxygen Therapy in Acute Acoustic Trauma

Çakır, Burak Ömür; Ercan, Ibrahim; Civelek, Senol; Körpınar, Şefika; Toklu, Akýn Savaş; Gedik, Ozlem; Işik, Gökhan; Sayın, İbrahim; Turgut, Suat

doi:10.1097/01.mao.0000224080.77849.3d

Cited by 20 publications

(20 citation statements)

References 15 publications

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“…Application of pre-or posttreatment via hyperbaric oxygen therapy (HBOT) has been widely reported to play a major protective role in the reduction of injured cochlear hair cells and a defensive role against acute NIHL (15)(16)(17)(18). However, several studies argue that HBOT may intensify the level of oxidative stress; the negative effect of HBOT on acute acoustic trauma has been also reported (19). Overall, there is no consensus regarding the ideal therapeutic time window or pressure for HBOT.…”

Section: Discussionmentioning

confidence: 98%

“…Such negative effects may be associated with the increased level of cellular free radical species (such as ROS), caused by NBHO treatment within the first hour of noise exposure, which normally goes beyond the capacity of antioxidant defense mechanisms (19). In other words, time is needed for activation of indigenous defense enzymes to reduce the effects of ROS metabolites within the cells.…”

Section: Discussionmentioning

confidence: 99%

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The Effects of Normobaric Hyperoxia Pre- and Post-treatment on the Development of Noise-Induced Hearing Loss in Rats

et al. 2017

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Background: Occupational noise exposure is one of the leading factors for developing noise-induced hearing loss (NIHL), particularly among workers worldwide. The literature review reveals that beside conventional strategies for preventing NIHL, multiple interventions can be applied to reduce or prevent such disorders. The present study aimed to investigate the preventive effects of normobaric hyperoxia pre-and post-treatment on the development of NIHL in rats. Methods: Four groups of male Wistar rats were exposed to pure oxygen alone, noise alone, or oxygen plus noise for 6 hours a day, 5 days a week for 4 weeks. One group served as the control and received neither noise nor oxygen. Animals in the noise groups were exposed to high-pass white noise of 100 dB SPL, centred at 8 KHz. The treatment protocols were based on inhalation of pure normobaric oxygen (95%) for 3 hours in a chamber either before or after noise exposure. The auditory brainstem responses (ABRs) for click and 4, 6, 8, 12, and 16 kHz stimuli, as well as distortion product otoacoustic emissions (DPOAEs) at 4, 6, 8, and 10 kHz, were recorded to assess the level of hearing impairment before exposure and 4 weeks post-exposure. Results:The results showed that pre-treatment of rats with 3 hours of normobaric hyperoxia contributed to a significant reduction in ABR threshold shifts, while improving the DPOAE amplitudes (P < 0.01). However, three hours of post-treatment did not produce any comparable results in terms of ABR threshold shifts or DPOAE amplitude improvements. DPOAE amplitudes and ABR threshold shifts remained almost constant during exposure in the control group (P > 0.05). Conclusions: Pre-and post-treatment with normobaric hyperoxia seem to produce protective effects through either boosting cellular oxygenation or maximizing antioxidant enzyme activities and tolerance against noise-induced ischemia and hypoxia in the cochlea. Therefore, application of normobaric hyperoxia pre-or post-treatment, along with other conventional protective strategies, can be helpful in the fight against NIHL.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

The Effects of Normobaric Hyperoxia Pre- and Post-treatment on the Development of Noise-Induced Hearing Loss in Rats

et al. 2017

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“…Following a noise exposure, the hearing damage could also be due to the loss of the protective effect of the efferent fibres, perhaps mediated by the lateral olivocochlear neurons that synapse beneath the inner hair cells (Attanasio et al, 1999). The transitory auditory injury observed in our test group may also be related to the hyperbaric work environment: oxygen toxicity is a problem in diving and can have fatal consequences in the water; past experiences made on divers, highlighted the significant presence of hearing disturbances and disorientation, and demonstrated changes of the Central Nervous System in hyperbaric conditions (Cakir et al, 2006). Experiences done on animals (guinea pig) showed that repeated hyperbaric exposures that were considered to be safe did cause damage to the cochlear system (Zheng & Gong, 1992).…”

Section: Effects Of Sonar On Human Hearingmentioning

confidence: 89%

The Effect of Sonar on Human Hearing

Mora¹,

Penco²,

Guastini³

2011

Sonar Systems

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“…Acoustic trauma results in structural changes such as rupture of the cell membranes, reduction of cochlear b flow and destruction of cochlear hair cellsand/or dendrites of primary auditory neurons [1][2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…The hearing organ exposure to acoustic superstimulation by an intense impulse sound, may cause a sudden sensorineural hearing loss and occur due to altered cochlear oxygenation, decreased cochlear blood flow, damage to cell membranes, metabolic effects of free radicals, altered neurotransmission and apoptosis [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Morphological and Functional Positive Effect with the Association of Hyperbaric Oxygen Therapy and Corticoid Against Acute Acoustic Trauma

Colombari¹

2014

AJBLS

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Abstract:Studies describe the use of corticosteroids as the best alternative to treat acoustic trauma, but recent studies point to their combination with hyperbaric oxygen therapy (HBOT) as the major benefit in lesions by noise. This study aimed to evaluate the association between HBOT and corticoid therapy (CT). Female guinea pigs were exposed to a white noise on 4 kHz at 110 dB SPL during 72 hours and divided into three treatment groups: HBOT, CT and the combination of both therapies (HBOCT). The treatment lasted five days, being a therapy session per day. All animals were exposed to Distortion Product Otoacoustic Emissions and Brainstem Auditory Evoked Potentials in three moments: before and after exposure to the noise and after the treatment. All cochleae were examined by scanning electron microscopy. Although not statistically significant, the anatomical and functional findings concluded that the association HBOCT played a better otoprotective and therapeutic effect compared to those same therapies alone.

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Negative Effect of Immediate Hyperbaric Oxygen Therapy in Acute Acoustic Trauma

Abstract: Immediate HBOT in acoustic trauma treatment is not necessary; on the contrary, it has an adverse effect.

Cited by 20 publications

References 15 publications

The Effects of Normobaric Hyperoxia Pre- and Post-treatment on the Development of Noise-Induced Hearing Loss in Rats

The Effects of Normobaric Hyperoxia Pre- and Post-treatment on the Development of Noise-Induced Hearing Loss in Rats

The Effect of Sonar on Human Hearing

Morphological and Functional Positive Effect with the Association of Hyperbaric Oxygen Therapy and Corticoid Against Acute Acoustic Trauma

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