Negative correlation between circulating integrin α4+ group 3 innate lymphoid cells and the severity of type 2 diabetes

Zhuang, Yu-Pei; Pan, Zhao-Yu; Huang, Jianming; Zhou, Hongguang; Yang, Xiaorong; Zhong, Hao‐Jie

doi:10.1016/j.intimp.2023.110237

Cited by 2 publications

(3 citation statements)

References 39 publications

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“… 38 Several studies have demonstrated the importance of ILC3 in the regulation of tissue homeostasis and their role in regulating inflammatory T cell responses. 39 ILC3s have been found downregulated in the blood of patients with GPA, 40 T2D, 41 SLE 42 and RA, 43 relative to healthy controls. ILC3c is implicated in gut homeostasis maintenance and gastrointestinal immune responses.…”

Section: Discussionmentioning

confidence: 97%

Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types

Tchitchek,

Binvignat,

Roux

et al. 2024

Ann Rheum Dis

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ObjectivesBased on genetic associations, McGonagle and McDermott suggested a classification of autoimmune and autoinflammatory diseases as a continuum ranging from purely autoimmune to purely autoinflammatory diseases and comprising diseases with both components. We used deep immunophenotyping to identify immune cell populations and molecular targets characterising this continuum.MethodsWe collected blood from 443 patients with one of 15 autoimmune or autoinflammatory diseases and 71 healthy volunteers. Deep phenotyping was performed using 13 flow cytometry panels characterising over 600 innate and adaptive cell populations. Unsupervised and supervised analyses were conducted to identify disease clusters with their common and specific cell parameters.ResultsUnsupervised clustering categorised these diseases into five clusters. Principal component analysis deconvoluted this clustering into two immunological axes. The first axis was driven by the ratio of LAG3+ to ICOS+ in regulatory T lymphocytes (Tregs), and segregated diseases based on their inflammation levels. The second axis was driven by activated Tregs and type 3 innate lymphoid cells (ILC3s), and segregated diseases based on their types of affected tissues. We identified a signature of 23 cell populations that accurately characterised the five disease clusters.ConclusionsWe have refined the monodimensional continuum of autoimmune and autoinflammatory diseases as a continuum characterised by both disease inflammation levels and targeted tissues. Such classification should be helpful for defining therapies. Our results call for further investigations into the role of the LAG3+/ICOS+ balance in Tregs and the contribution of ILC3s in autoimmune and autoinflammatory diseases.Trial registration numberNCT02466217.

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Section: Discussionmentioning

confidence: 97%

Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types

Tchitchek,

Binvignat,

Roux

et al. 2024

Ann Rheum Dis

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show abstract

“…Previous studies have implicated ILC3s in various metabolic and chronic liver diseases. 21 , 33 , 34 In patients with type 2 diabetes, the frequency of peripheral ILC3s is significantly lower than that in healthy individuals, and there is a negative correlation between the levels of fasting glucose and glycated hemoglobin and the frequency of peripheral ILC3s. 34 In contrast, our previous study revealed that patients with hyperuricemia present significantly higher levels of ILC3s in PBMCs, which are positively correlated with disease severity.…”

Section: Discussionmentioning

confidence: 99%

“… 21 , 33 , 34 In patients with type 2 diabetes, the frequency of peripheral ILC3s is significantly lower than that in healthy individuals, and there is a negative correlation between the levels of fasting glucose and glycated hemoglobin and the frequency of peripheral ILC3s. 34 In contrast, our previous study revealed that patients with hyperuricemia present significantly higher levels of ILC3s in PBMCs, which are positively correlated with disease severity. 33 Moreover, Wang et al observed a higher prevalence of circulating ILC3s among individuals with cirrhosis, a trend that further exacerbates as the disease advances.…”

Section: Discussionmentioning

confidence: 99%

Washed microbiota transplantation promotes homing of group 3 innate lymphoid cells to the liver via the CXCL16/CXCR6 axis: a potential treatment for metabolic-associated fatty liver disease

Zhong,

Zhuang,

Xie

et al. 2024

Gut Microbes

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Negative correlation between circulating integrin α4+ group 3 innate lymphoid cells and the severity of type 2 diabetes

Cited by 2 publications

References 39 publications

Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types

Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types

Washed microbiota transplantation promotes homing of group 3 innate lymphoid cells to the liver via the CXCL16/CXCR6 axis: a potential treatment for metabolic-associated fatty liver disease

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