Negative associations between PBDE levels and thyroid hormones in cord blood

Lin, Shu-Ming; Chen, Fu‐An; Huang, Ya‐Fang; Hsing, Liang-Lan; Chen, Lingling; Wu, Lan-Shiang; Liu, Te-Sen; Chang-Chien, Gou-Ping; Chen, Kuan‐Chung; Chao, How‐Ran

doi:10.1016/j.ijheh.2010.10.002

Cited by 78 publications

(55 citation statements)

References 35 publications

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“…Similar to the findings of our previous study (Lin et al, 2011), in a cohort study of infants born in the US indicates negative associations between cord blood levels of BDE-100 and BDE-153 and cord blood values of total T4 and FT3 (Herbstman et al, 2008). In contrast, several human studies that assess the associations between PBDEs and thyroid hormones in cord blood find no significant relation ( Mazdai et al, 2003;Kim et al, 2009;Zhang et al, 2010;Chevrier et al, 2011;Gascon et al, 2011;Kim et al, 2011).…”

Section: Pbdes and Thyroid Hormonessupporting

confidence: 85%

“…Our previous report shows that higher cord blood levels of are significantly associated with lower cord blood levels of T3 and FT3, whereas increased BDE-100 are positively correlated with a higher T4/T3 ratio (Lin et al, 2011). Similar to the findings of our previous study (Lin et al, 2011), in a cohort study of infants born in the US indicates negative associations between cord blood levels of BDE-100 and BDE-153 and cord blood values of total T4 and FT3 (Herbstman et al, 2008).…”

Section: Pbdes and Thyroid Hormonessupporting

confidence: 83%

“…Many epidemiological studies that evaluate associations of PBDEs exposure and thyroid hormones in adults and newborns have been published previously, but their results are not consistent (Hagmar et al, 2001;Mazdai et al, 2003;Herbstman et al, 2008;Turyk et al, 2008;Dallaire et al, 2009;Kim et al, 2009;Roze et al, 2009;Chevrier et al, 2010;Zhang et al, 2010;Chevrier et al, 2011;Eggesbø et al, 2011;Gascon et al, 2011;Lin et al, 2011). A few studies report the negative impact of cord blood PBDEs on levels of human thyroid hormones after in utero exposure (Herbstman et al, 2008;Lin et al, 2011), but most studies conducted in humans have found no correlations. Recent studies in humans have not consistently concluded that PBDEs exposure disrupts thyroid functions.…”

Section: Pbdes and Thyroid Hormonesmentioning

confidence: 99%

“…Only a few epidemiological studies have been conducted on the connection between HBCD and breast milk. Currently our greatest concern is that PBDE exposure may cause alterations in thyroid hormone homeostasis and developmental neurotoxicity during these formative years Lin et al, 2011;Shy et al, 2011;Shy et al, 2012), but it is still unknown whether higher levels of HBCDs and PBDD/DFs in infants or toddlers may induce adverse health effects, particularly in the disruption of thyroid hormones or interference with neurodevelopment and neurobehavioral development.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Brominated POPs on the Neurodevelopment and Thyroid Hormones of Young Children in an Indoor Environment—A Review

Chao

Huang

Hsu

et al. 2014

Aerosol Air Qual. Res.

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The goal of this report is to evaluate brominated persistent organic pollutants (POPs) in the indoor air and dust to further assess their health effects on thyroid hormones and neurodevelopment in infants, toddlers, and young children. This category of brominated POPs includes polybrmonated diphenyl ethers (PBDEs), hexabromocyclododecanes (HBCDs), polybrominated biphenyls (PBBs), and polybrominated dibenzo-p-dioxins (PBDD/DFs). These organobromines are lipophilic compounds which resist physical and chemical degradation in the environment and biota, and so easily bioaccumulate in adipose tissue. Brominated POPs, particularly in brominated fire retardants (BFRs) such as PBDEs, HBCDs, and PBBs, are ubiquitous in indoor environments due to their inadvertent release from certain consumer products. Some of these organobromines have been recognized in some in-vitro and in-vivo studies to be neurotoxins and disrupt thyroid hormones, although the evidence from actual epidemiological studies is contradicted and inconsistent, especially for infants, toddlers, and young children, who are particularly vulnerable to these substances as they spend most of their time in the home. This report focuses on exposure to PBDEs, HBCDs, PBBs, and PBDD/DFs in the indoor dust and on the indoor aerosol, to explore their association with human health, particularly the disruption of thyroid hormones and neurodevelopment in early childhood.

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Section: Pbdes and Thyroid Hormonessupporting

confidence: 85%

Section: Pbdes and Thyroid Hormonessupporting

confidence: 83%

Section: Pbdes and Thyroid Hormonesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Brominated POPs on the Neurodevelopment and Thyroid Hormones of Young Children in an Indoor Environment—A Review

Chao

Huang

Hsu

et al. 2014

Aerosol Air Qual. Res.

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“…PBDEs with high lipophilicity are easily bioaccumulated in the biota, including terrestrial and aquatic living organisms . To raise both official and public concern, the toxicological endpoints of human exposure to PBDEs in current scientific reports, particularly for young children include disruption of thyroid hormone secretion (Lin et al, 2011;Shy et al, 2012), neurodevelopment or neurobehavioral development Shy et al, 2011), and male or female reproductive functions (Chao et al, 2007;Wang et al, 2008;Chao et al, 2010;Abdelouahab et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Pollution Characteristics and Diurnal Variations in Polybrominated Diphenyl Ethers in Indoor and Outdoor Air from Vehicle Dismantler Factories in Southern Taiwan

Gou

Hsu

Chao

et al. 2016

Aerosol Air Qual. Res.

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Polybrominated diphenyl ethers (PBDEs) are a class of the emerging persistent organic pollutants that have shown potential harmful effects in in-vivo and human studies. Our goal was to investigate 30 airborne PBDEs in day-to-night or indoor-to-outdoor in three vehicle dismantling factories located in southern Taiwan to assess worker risks. Thirty PBDEs including 15, 17, 28, 47, 49, 66, 71, 77, 85, 99, 100, 119, 126, 138, 139, 140, 153, 154, 156, 183, 184, 191, 196, 197, 203, 206, 207, 208, and 209 were analyzed using high-resolution-gas chromatography/high-resolution-mass-spectrometer. Levels of airborne Σ 30 PBDEs were 275, 336, 200 and 494 p gm -3 in indoor daytime, indoor nighttime, outdoor daytime, and outdoor nighttime, respectively, and their differences were not significant. BDE-209 was the predominant congener among the 30 PBDEs consisting of 82.5-97.9% of Σ 30 PBDEs in both indoor and outdoor air. Pollution characterizations of the PBDE patterns were similar in air samples except for the outdoor air in the nighttime. Diurnal variations in PBDEs in both indoor and outdoor air were not observed. A principal component analysis was used to test for possible sources of PBDE contamination. BDE-209 in outdoor air was possibly contributed from PBDEs in indoor air, particularly from BDE-209. Characteristics of diurnal PBDE contamination in indoor and outdoor air in vehicle dismantling factories were linked to commercial technical OctaBDE (Bromkal 79-8DE) and DecaBDEs (Bromkal 82-0D and Saytex 102E) mixtures. The highest PBDE intakes of workers via inhalation were assessed as 41.8 and 32.7 pg kg -1 bw day -1 for male and female adults, respectively. It was hypothesized that airborne PBDEs in indoor factories are released from the surface of DecaBDE or OctaBDE technical formulations and influence outdoor air through ventilation or natural dispersion. However, occupational exposure through inhalation might be an important PBDE contamination pathway, but it is minor compared to PBDE dietary intake.

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Effects and Predicted Consequences of Persistent and Bioactive Organic Pollutants on Thyroid Function

Giera¹

2013

Effects of Persistent and Bioactive Organic Pollutants on Human Health

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Negative associations between PBDE levels and thyroid hormones in cord blood

Cited by 78 publications

References 35 publications

Impact of Brominated POPs on the Neurodevelopment and Thyroid Hormones of Young Children in an Indoor Environment—A Review

Impact of Brominated POPs on the Neurodevelopment and Thyroid Hormones of Young Children in an Indoor Environment—A Review

Pollution Characteristics and Diurnal Variations in Polybrominated Diphenyl Ethers in Indoor and Outdoor Air from Vehicle Dismantler Factories in Southern Taiwan

Effects and Predicted Consequences of Persistent and Bioactive Organic Pollutants on Thyroid Function

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