Negative and competitive social interactions are related to heightened proinflammatory cytokine activity

Chiang, Jessica J.; Eisenberger, Naomi I.; Seeman, Teresa E.; Taylor, Shelley E.

doi:10.1073/pnas.1120972109

Cited by 105 publications

(71 citation statements)

References 68 publications

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“…Moreover, female adolescents who reported experiencing episodes of targeted rejection evidenced higher levels of proinflamatory gene expression than those who did not (Murphy et al, 2013). Similarly, college students who reported experiencing more negative and competitive social interactions on a daily basis showed higher levels of IL-6 and of the soluble receptor for tumor necrosis factor-α (sTNFαRII; Chiang et al, 2012). Not surprisingly, these effects are observed in response to later life stressors as well.…”

Section: Exposure To Real-world Social Stressmentioning

confidence: 98%

In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior

Eisenberger

Moieni

Inagaki

et al. 2016

Neuropsychopharmacol

288

220

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Although it has commonly been assumed that the immune system and the processes that govern social behavior are separate, non-communicating entities, research over the past several decades suggests otherwise. Considerable evidence now shows that inflammatory processes and social behavior are actually powerful regulators of one another. This review first summarizes evidence that inflammatory processes regulate social behavior, leading to characteristic changes that may help an individual navigate the social environment during times of sickness. Specifically, this review shows that inflammation: (1) increases threatrelated neural sensitivity to negative social experiences (eg, rejection, negative social feedback), presumably to enhance sensitivity to threats to well-being or safety in order to avoid them and (2) enhances reward-related neural sensitivity to positive social experiences (eg, viewing close others and receiving positive social feedback), presumably to increase approach-related motivation towards others who might provide support and care during sickness. Next, this review summarizes evidence showing that social behavior also regulates aspects of inflammatory activity, preparing the body for situations in which wounding and infection may be more likely (social isolation). Here, we review research showing: (1) that exposure to social stressors increases proinflammatory activity, (2) that individuals who are more socially isolated (ie, lonely) show increased proinflammatory activity, and (3) that individuals who are more socially isolated show increased proinflammatory activity in response to an inflammatory challenge or social stressor. The implications of the co-regulation of inflammation and social behavior are discussed.

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Section: Exposure To Real-world Social Stressmentioning

confidence: 98%

In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior

Eisenberger

Moieni

Inagaki

et al. 2016

Neuropsychopharmacol

288

220

View full text Add to dashboard Cite

show abstract

“…In this research, we assessed changes in IL-6 in oral mucosal transudate (OMT). While levels of inflammatory cytokines in OMT are not a reflection of systemic inflammation, which is assessed through blood (Fernandez-Botran, Miller, Burns, & Newton, 2011), inflammatory markers in OMT have been shown to be affected by acute situational stressors (Chiang, Eisenberger, Seeman, & Taylor, 2012;John-Henderson et al, 2014;Slavich et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Cytokine responses and math performance: The role of stereotype threat and anxiety reappraisals

John‐Henderson¹,

Rheinschmidt²,

Mendoza‐Denton³

2015

Journal of Experimental Social Psychology

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This research independently manipulated two potential attenuators of stereotype threat -reappraisal of anxiety and test framing -to explore their independent and combined effects. Female participants took a difficult math exam that was described as gender-biased or gender-fair and were told that anxious arousal could positively impact performance or were given no information regarding arousal. Levels of the cytokine Interleukin-6 (IL-6), an immune marker of inflammation, were measured in oral mucosal transudate (OMT) both before and after the exam. Our findings indicate that directing reappraisal of physiological arousal attenuated increases in IL-6 across test framing conditions, and was especially effective under stereotype threat (i.e., gender-biased test condition). Reappraisal also mapped onto better test performance in the threat condition. Together, these findings provide insight into the unique and interactive effects of two situational interventions meant to reduce stereotype threat, indexed here by both physiological and performance-based correlates of threat.

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“…Del mismo modo, el conflicto social con amigos, familia y compañeros está asociado con bajos niveles de cortisol diurno y con curvas planas de cortisol sobre el curso del día, sugiriendo desregulación del eje HHA 68 . Finalmente, el estrés interpersonal presente en las interacciones sociales de adolescentes o las interacciones negativas y competitivas caracterís-ticas de la adultez joven, han sido vinculadas con niveles más elevados de respuesta inflamatoria en un estado de reposo y en respuesta a un estresor social 69,70 .…”

Section: Estrés Interpersonal Negatividad Social Y Saludunclassified

How stress gets under the skin o cómo el estrés psicológico se introduce bajo la piel

2014

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How stress gets under the skina frase en Inglés "How stress gets under the skin" es comúnmente empleada por psicólo-gos de la salud para referirse a cómo el estrés psicológico contribuye a aumentar el riesgo de desarrollar enfermedades crónicas, por medio de la desregulación de sistemas fisiológicos. El estrés psicológico ocurre cuando una persona percibe que una demanda o evento estresante excede sus recursos para responder 1 . Tradicionalmente, estresores agudos, aquellos que derivan de una exposición breve o tiempo limitado (ruptura de una relación afectiva o la exposición a fenómenos naturales), así como también estresores crónicos, aquellos que implican un período prolongado o una exposición reiterada al mismo evento (estrés laboral, percepción de discriminación, cuidar niños con discapacidad física severa, etc.), han sido vinculados con desenlaces negativos tanto en salud física como mental 2,3 . Asimismo, el estrés derivado de las relaciones sociales, como por ejemplo el estrés interpersonal, es reportado como el tipo de estresor más frecuente en la vida de las personas y es un predictor más potente que estresores no sociales de salud física y salud mental 4 . Los aspectos negativos de las relaciones sociales, pueden ser colectivamente referidos como "negatividad social", e implican conductas dirigidas al receptor que son percibidas como aversivas o no deseadas 5 . Tanto estresores agudos y crónicos, como aquellos derivados de las relaciones sociales pueden tener efectos negativos sobre la salud física como mental, ya sea por medio de mecanismos conductuales y/o mecanismos fisiológicos (Figura 1). Si bien la dirección de estas asociaciones puede ser bidireccional, es decir, es posible pensar a la enfermedad física como fuente de estrés psicológico o viceversa una fuente de estrés psicológico puede asociarse con una enfermedad física, este

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Negative and competitive social interactions are related to heightened proinflammatory cytokine activity

Cited by 105 publications

References 68 publications

In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior

In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior

Cytokine responses and math performance: The role of stereotype threat and anxiety reappraisals

How stress gets under the skin o cómo el estrés psicológico se introduce bajo la piel

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