Negative Air Ions Alleviate Particulate Matter-Induced Inflammation and Oxidative Stress in the Human Keratinocyte Cell Line HaCaT

Kim, Min Jeong; Jeong, Guk Jin; Hong, Ji Yeon; Park, Kui Young; Lee, Mi-Kyung; Seo, Seong Jun

doi:10.5021/ad.2021.33.2.116

Cited by 9 publications

(11 citation statements)

References 22 publications

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“…This indicated accelerated wound healing via the anti-inflammatory and antioxidant activities of NAIs. A recent report has indicated NAIs exerted anti-inflammatory and antioxidant effects in HaCaT cells exposed to PM implicating its application to the prevention and treatment of inflammatory skin diseases [ 19 ]. The use of antioxidant and anti-inflammatory strategies through the reduction of neutrophil adhesion and leukocyte recruitment, or inhibition of proinflammatory cytokines release could promote wound healing [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, the mechanism was not clarified. Kim et al [ 19 ] demonstrated that NAIs treatment inhibited intracellular reactive oxygen species production, p38 mitochondrial protein initiator kinase activation, and activation protein 1 (c-Fos and c-Jun) activation in human keratinocyte cell line HaCaT implicating antioxidant and anti-inflammatory effects. Based on these information, this study was designed to explore the NAIs effect on two inflammatory animal models: 1) LPS induced ALI and inflammation in rats, and 2) wound healing of skins in DM rats.…”

Section: Introductionmentioning

confidence: 99%

“…Sirota et al [12] showed that inhaling NAIs for 60 min at the dosage of 320-350 000 ions/ cm 2 in animals activated the respiratory organs by acting directly on mucosal and blood, but their mechanism is unknown. Recently, the outbreak of coronavirus disease 2019 (COVID- 19) caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) has spread widely in the world [13]. SARS-CoV and SARS-CoV-2 could induce acute lung injury (ALI) and inflammation, which is mimicked by lipopolysaccharide (LPS), a bacterial endotoxin present on the outer membrane of Gram-negative bacteria [14], implicating SARS-CoV-2 and LPS through similar pathways of binding toll-like receptor-4 (TLR4) to activate angiotensin converting enzyme 2 (ACE2), to induce ALI and hyperinflammation [15,16].…”

Section: Introductionmentioning

confidence: 99%

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Negative air ions through the action of antioxidation, anti-inflammation, anti-apoptosis and angiogenesis ameliorate lipopolysaccharide induced acute lung injury and promote diabetic wound healing in rat

Cheng

Li²,

Yao³

et al. 2022

PLoS ONE

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Negative air ions (NAIs) being bioactive and negative charged molecules may confer antioxidant and anti-inflammatory activity. We assessed the effect of NAIs on two inflammatory diseases in animal models including lipopolysaccharide (LPS) induced acute lung injury (ALI) and wound healing in diabetic rats. We used intra-tracheal infusion of LPS to induce ALI and made a full-thickness cutaneous wound in streptozotocin-induced diabetic female Wistar rats. We evaluated NAIs effects on reactive oxygen species amount, leukocyte infiltration, wound healing rate, western blot, and immunohistochemistry in the lungs of ALI and skin sections of wounds. Our data found NAIs exposed saline displayed higher antioxidant activity vs. non-exposed saline. NAIs exposure did not significantly affect arterial blood pressure and respiratory frequency in control and LPS treated groups. LPS increased leukocyte infiltration, caspase 3/Poly-ADP-ribose-polymerase-mediated apoptosis formation and decreased Beclin-1/LC3-II-mediated autophagy in lungs. NAIs exposure conferred pulmonary protection by depressed leukocyte infiltration and caspase 3/Poly-ADP-ribose-polymerase mediated apoptosis and enhanced LC3-II-mediated autophagy in LPS induced ALI. NAIs treatment resulted in a significantly accelerated wound closure rate, decreased erythrocyte accumulation and leukocyte infiltration mediated oxidative stress and inflammation, and upregulated expression of skin collagen, vascular endothelial growth factor receptor-2 (VEGFR-2) and factor transforming growth factor-beta 1 (TGF-β1) vs non-treated group. Based on these results, it is suggested that NAIs conferred a protection through the upregulating LC3-II-dependent autophagy mechanism and downregulating leukocyte infiltration mediated inflammation and caspase 3/Poly-ADP-ribose-polymerase signaling in the LPS-treated ALI and promoted diabetic wound healing through the enhancing skin collagen synthesis, VEGFR-2 and TGF-β1 pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Negative air ions through the action of antioxidation, anti-inflammation, anti-apoptosis and angiogenesis ameliorate lipopolysaccharide induced acute lung injury and promote diabetic wound healing in rat

Cheng

Li²,

Yao³

et al. 2022

PLoS ONE

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“…Kim et al. 7 studied the contribution of NAIs to the alleviation of particulate matter-induced inflammation and oxidative stress in the human keratinocyte cell line HaCaT. The results indicated that NAIs exerted preventive or therapeutic effects in various skin diseases that were induced and exacerbated by particulate matter.…”

mentioning

confidence: 99%

“…4,5 Liu et al 6 investigated the effect of NAIs on the cardiorespiratory function of children, and the results verified that increasing NAI concentration improved cardiac autonomic and respiratory functions. Kim et al 7 studied the contribution of NAIs to the alleviation of particulate matter-induced inflammation and oxidative stress in the human keratinocyte cell line HaCaT. The results indicated that NAIs exerted preventive or therapeutic effects in various skin diseases that were induced and exacerbated by particulate matter.…”

mentioning

confidence: 99%

Effect of germanium particle size on the negative air ion release and antimicrobial performances of germanium–polyamide 6 composite fibers

Zhi

Wang

et al. 2022

Textile Research Journal

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Germanium–polyamide 6 (Ge-PA6) fibers A, B and C containing germanium particles with sizes of D50 = 0.2, 2 and 7 μm were prepared using the melt spinning method. The effect of germanium particle size on the morphologies, mechanical properties, negative air ion (NAI) release and antimicrobial efficiencies of the two kinds of fibers were compared and analyzed. The NAI release and antimicrobial mechanisms of the Ge-PA6 fibers were also discussed. Results indicated that the germanium particles dispersed well inside the PA6 fiber substrate in the range of 1–3 wt%, and smaller particles help the fiber to obtain better diameter evenness and mechanical performance compared with larger ones. The stronger extranuclear electron activity and electrostatic voltage along the C-axis allow the fiber that contains smaller germanium particles to produce more NAIs compared to that containing larger particles. Some 780 and 1587 ions/m3 of NAIs could be produced by fiber A under the circumstance of 35°C and 40 N extrusion force when the germanium concentration was fixed at 3 wt%. The excellent NAI release property of the Ge-PA6 fiber endows it with inspiring antibacterial activity against S. aureus and C. albicans with a 12 h bacteriostasis rate of more than 90% at human body temperature. These results indicated Ge-PA6 fibers have great application potential in apparel and medical textiles.

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Biological effects of negative air ions on human health and integrated multiomics to identify biomarkers: a literature review

Xiao

Wei

Petersen

et al. 2023

Environ Sci Pollut Res

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Environmental pollution seriously affects human health. The concentration of negative air ions (NAIs), which were discovered at the end of the nineteenth century, is one of the factors used to evaluate air quality. Additionally, NAIs have been widely considered markers by scholars due to their unique biological function. The aim of this study was to summarize existing research and propose future research on the generation and temporal and spatial dynamic patterns of NAIs concentrations as well as the relationship between NAIs and human health. We identified 187 studies (published January 2013–January 2023) that met our inclusion criteria. Fourteen English studies evaluated the effects of NAIs on depression, the cardiovascular system, the respiratory system, reproduction and development, cognition, and sports muscle injury. Only two studies reported the associations of NAIs exposure with metabolic omics. NAIs concentrations vary temporally with solar radiation, air temperature, and relative humidity, while the temporal dynamic patterns of NAIs are affected by season, time, meteorological factors, air quality index, geographical location, forest vegetation, and other factors. Researchers have shown that exposure to NAIs may benefit our health by changing amino acid metabolism, which mainly manifests as increased anti-inflammation and reduced inflammation and antioxidation. Furthermore, exposure to NAIs promotes energy production, affects the expression of c-fos, and regulates 5-HT levels. There has been considerable interest in the potential effects of NAIs on human health and well-being, but the conclusions have been inconsistent and the mechanisms remain unclear. The use of omics to elucidate the biological mechanism of NAIs is relatively new and has some advantages. Graphical Abstract

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Negative Air Ions Alleviate Particulate Matter-Induced Inflammation and Oxidative Stress in the Human Keratinocyte Cell Line HaCaT

Cited by 9 publications

References 22 publications

Negative air ions through the action of antioxidation, anti-inflammation, anti-apoptosis and angiogenesis ameliorate lipopolysaccharide induced acute lung injury and promote diabetic wound healing in rat

Negative air ions through the action of antioxidation, anti-inflammation, anti-apoptosis and angiogenesis ameliorate lipopolysaccharide induced acute lung injury and promote diabetic wound healing in rat

Effect of germanium particle size on the negative air ion release and antimicrobial performances of germanium–polyamide 6 composite fibers

Biological effects of negative air ions on human health and integrated multiomics to identify biomarkers: a literature review

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