Negative affectivity predicts decreased pain tolerance during low-grade inflammation in healthy women

Lacourt, Tamara E.; Zanten, Jet J.C.S. Veldhuijzen van; Bosch, Jos A.; Drayson, Mark T.; Doornen, Lorenz J.P. van

doi:10.1016/j.bbi.2014.10.003

Cited by 28 publications

(26 citation statements)

References 32 publications

(38 reference statements)

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“…Indeed, inflammation is a hallmark of ageing and replication of results to such a relevant group is advised. Moreover, even thoughLacourt et al, (2015) showed that vaccination does not affect pain tolerance or pain threshold and no side effects were reported in the current study, pain could have influenced performance and lack of assessing pain is a limitation of the study. Similarly, even though modified versions of the Profile of Mood Scales-Short Form (POMS-SF) have been used extensively in typhoid vaccination studies (e.g.,Brydon et al, 2009;, the use of a modified POMS-SF to measure mood and sickness can be considered as a limitation of…”

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confidence: 59%

“…Such alternative is provided by inflammation-induction through vaccination against Salmonella typhi (the causal agent of typhoid fever). Vaccination likewise reliably initiates an acute systemic inflammatory response, lasting up to 12 hours, but without generating flu-like symptoms Lacourt et al, 2015;Paine, Ring, Bosch, Drayson, & Veldhuijzen van Zanten, 2013 but also Harrison et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Low-grade inflammation decreases emotion recognition – Evidence from the vaccination model of inflammation

Balter

Hulsken

Aldred

et al. 2018

Brain, Behavior, and Immunity

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The ability to adequately interpret the mental state of another person is key to complex human social interaction. Recent evidence suggests that this ability, considered a hallmark of 'theory of mind' (ToM), becomes impaired by inflammation. However, extant supportive empirical evidence is based on experiments that induce not only inflammation but also induce discomfort and sickness, factors that could also account for temporary social impairment. Hence, an experimental inflammation manipulation was applied that avoided this confound, isolating effects of inflammation and social interaction. Forty healthy male participants (mean age = 25, SD = 5 years) participated in this double-blind placebo-controlled crossover trial. Inflammation was induced using Salmonella Typhi vaccination (0.025 mg; Typhim Vi, Sanofi Pasteur, UK); saline-injection was used as a control. About 6 h 30 m after injection in each condition, participants completed the Reading the Mind in the Eyes Test (RMET), a validated test for assessing how well the mental states of others can be inferred through observation of the eyes region of the face. Vaccination induced systemic inflammation, elevating IL-6 by +419% (p < .001), without fever, sickness symptoms (e.g., nausea, light-headedness), or mood changes (all p's > .21). Importantly, compared to placebo, vaccination significantly reduced RMET accuracy (p < .05). RMET stimuli selected on valence (positive, negative, neutral) provided no evidence of a selective impact of treatment. By utilizing an inflammation-induction procedure that avoided concurrent sicknesses or symptoms in a double-blinded design, the present study provides further support for the hypothesis that immune activation impairs ToM. Such impairment may provide a mechanistic link explaining social-cognitive deficits in psychopathologies that exhibit low-grade inflammation, such as major depression.

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confidence: 59%

Section: Introductionmentioning

confidence: 99%

Low-grade inflammation decreases emotion recognition – Evidence from the vaccination model of inflammation

Balter

Hulsken

Aldred

et al. 2018

Brain, Behavior, and Immunity

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“…Overall, we could observe that pregnant women presented similar glucose and total cholesterol levels [25][26][27] ; and greater LDL and HDL-cholesterol, 25,27 and triglycerides concentrations. 25 Regarding the inflammatory markers, pregnant women showed higher levels of IL-1, 28 IL-6, 25-29 IL-8, 28 IL-10, 28 IFN-γ, 28 and TNF-α 25,27,29 than non-pregnant women of similar characteristics. These comparisons and previous evidence 1,6,30,31 seem to support the idea that early pregnant women are predisposed to a mild pro-inflammatory profile, despite the fact that changes on cardiometabolic markers are not very accentuated.…”

Section: Discussionmentioning

confidence: 98%

Association of sedentary time and physical activity levels with immunometabolic markers in early pregnancy: The GESTAFIT project

Acosta‐Manzano

Acosta

Femia

et al. 2019

Scandinavian Med Sci Sports

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Objectives:To analyze the association of sedentary time and physical activity (PA) intensity levels with immunometabolic markers during early pregnancy; and to examine if meeting the PA recommendations is associated with the immunometabolic profile of pregnant women. Methods: Fifty Caucasian pregnant women (age: 32.8 ± 4.7 years old, body mass index: 24.2 ± 4.1kg/m 2 , gestational age: 17 ± 1.5weeks) participated in this crosssectional study (from September 2015 through May 2016). Sedentary time and PA intensity levels were objectively measured with triaxial accelerometer (seven consecutive valid days). Fasting serum glucose, total cholesterol, phospholipids, and triglycerides were assessed with standard methods. Serum pro-inflammatory and anti-inflammatory cytokines (fractalkine, interleukin-1β, interleukin-6, interleukin-8, interleukin-10, interferon-γ, and tumor necrosis factor-α) were measured using Luminex xMAP technology. Results: Sedentary time and PA were not correlated with any glycemic or lipid marker (P > .05). After adjusting for the potential confounders, vigorous PA showed a positive non-significant association with interleukin-6 (P = .06), and bouts of moderatevigorous PA was inversely associated with interleukin-1β and interferon-γ (P = .02 and P = .04, respectively). Meeting the PA guidelines was inversely associated with interleukin-1β and positively associated with interleukin-8 (P = .01 and P = .04, respectively). These associations disappeared after controlling for multiplicity. | 149ACOSTA-MANZANO eT Al. | 157ACOSTA-MANZANO eT Al.Víctor Segura-Jiménez https://orcid.

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“…The physical examination and medical history allowed for assessment of chronic conditions that are characterized by musculoskeletal pain (e.g., arthritis) and abnormal joints or musculature that could might result in increased numbers of tender points. Elevated peripheral inflammation has previously been associated with increased pain sensitivity both under basal conditions 38 , and during experimentally induced inflammation with immunogenic challenges 70 an effect that may be mediated by increases in negative affective processes 34 . Sympathetic nervous system activation measured by urinary catecholamine (as in the MIDUS study) has also been linked to increased reports of musculoskeletal pain.…”

Section: Discussionmentioning

confidence: 99%

Somatic Awareness and Tender Points in a Community Sample

Schrepf

Harper

Williams

et al. 2016

The Journal of Pain

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Somatic awareness (SA) refers to heightened sensitivity to a variety of physical sensations and symptoms. Few attempts have been made to dissociate the relationship of SA and affective symptoms with pain outcomes. We used a validated measure of mood and anxiety symptoms that includes questions related to SA to predict the number of tender points found on physical examination in a large cross-sectional community sample (the Midlife in the United States [MIDUS] Biomarker study). General distress, positive affect, and SA, which were all significantly associated with tender point number in bivariate analyses, were used as predictors of the number of tender points in a multivariate negative binomial regression model. In this model a greater number of tender points was associated with higher levels of SA (p = .02) but not general distress (p = .13) or positive affect (p = .50). Follow-up mediation analyses indicated that the relationship between general distress and tender points was partially mediated by levels of SA. Our primary finding is that SA is strongly related to the number of tender points in a community sample. Mechanisms linking SA to the spatial distribution of pain sensitivity should be investigated further. Perspective This article presents an analysis of three overlapping psychological constructs and their relationship to widespread pain sensitivity on palpation. The findings suggest that somatic awareness is most strongly related to the spatial distribution of pain sensitivity and that further assessing it may improve our understanding of the relationship between psychological factors and pain.

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Negative affectivity predicts decreased pain tolerance during low-grade inflammation in healthy women

Abstract: NA moderated the effects of inflammation on pain tolerance. This finding is consistent with a synergistic model whereby inflammation may lower the threshold for pain reporting in individuals with increased vulnerability for somatic symptom reporting.

Cited by 28 publications

References 32 publications

Low-grade inflammation decreases emotion recognition – Evidence from the vaccination model of inflammation

Low-grade inflammation decreases emotion recognition – Evidence from the vaccination model of inflammation

Association of sedentary time and physical activity levels with immunometabolic markers in early pregnancy: The GESTAFIT project

Somatic Awareness and Tender Points in a Community Sample

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