Negative affect in systemic sclerosis

León, Leticia; Abásolo, Lydia; Redondo, Marta; Pérez-Nieto, Miguel Ángel; Rodríguez‐Rodríguez, Luis; Morales-Casado, María Isabel; Curbelo, Rafael; Jover, Juan A.

doi:10.1007/s00296-013-2852-7

Cited by 14 publications

(13 citation statements)

References 57 publications

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“…Another reason might be that several patients categorized in the N group presented with subnormal exercise capacity due to deconditioning. Chronic inflammation, pain, musculoskeletal disuse due to cutaneous lesions or arthritis, chronic anxiety and depression, social withdrawal or isolation due to disfigurement and potential adverse effects of corticosteroid use on emotional status and muscular function [25,26,27] are only some of the potential factors leading to decreased physical activity and increased exertional dyspnea among these patients, without evident heart or lung involvement being present.…”

Section: Discussionmentioning

confidence: 99%

Phenotyping Exercise Limitation in Systemic Sclerosis: The Use of Cardiopulmonary Exercise Testing

Boutou¹,

Pitsiou²,

Siakka³

et al. 2016

Respiration

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Background: Exercise impairment is a common symptom of systemic sclerosis (SSc), a disorder which is frequently complicated by cardiopulmonary involvement. Objectives: This study's aims were: (a) to define the prevalence and the potential causes of limited exercise capacity and (b) to study potential differences in clinical, radiological and functional characteristics and blood serology among SSc patients with exercise limitation of different etiology. Methods: Prospectively collected data on SSc patients who had conducted full lung function testing, blood serology, thorax high-resolution computed tomography, Doppler echocardiogram and a maximal cardiopulmonary exercise testing (CPET) were retrospectively analyzed. Using a CPET algorithm, patients were characterized as having normal or subnormal exercise capacity (N), respiratory limitation (RL), left ventricular dysfunction (LVD) or pulmonary vasculopathy (PV). Group comparisons were conducted using either one-way ANOVA or the Kruskal-Wallis test. A p value <0.05 was considered significant. Results: The study population consisted of 78 patients (53.7 ± 13.7 years old; 10.3% male). PV was present in 32.1%, LVD in 25.6% and RL in 10.2%, while 32.1% of the patients constituted the N group. The presence of antisclero-70 antibodies, low anaerobic threshold and low peak exercise capacity measures could discriminate LVD from the other groups. Low end-tidal carbon dioxide pressure and its change from rest to anaerobic threshold could discriminate between the PV, LVD and N groups, while respiratory restriction along with ventilatory inefficiency indices could differentiate the RL group from the rest. Conclusions: The combined evaluation of CPET gas exchange patterns with baseline measurements could discriminate the causes of exercise limitation among SSc patients.

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Section: Discussionmentioning

confidence: 99%

Phenotyping Exercise Limitation in Systemic Sclerosis: The Use of Cardiopulmonary Exercise Testing

Boutou¹,

Pitsiou²,

Siakka³

et al. 2016

Respiration

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“…Depression is more common in SSc patients than in patients with other rheumatic diseases [ 4 , 5 ]. Symptoms of depression occur in approximately one-third to two-thirds of patients with SSc [ 6 ], depending on which questionnaire is used and whether or not the prevalence of depression is based on valid interview methods [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Symptoms of depression occur in approximately one-third to two-thirds of patients with SSc [ 6 ], depending on which questionnaire is used and whether or not the prevalence of depression is based on valid interview methods [ 7 ]. Disease-specific symptoms such as reflux, constipation, dyspnea, digital ulcers, pain, fatigue, and changes in physical appearance are associated with negative emotions in SSc [ 4 ]. Depressive symptoms are associated with poor HRQL [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Validity and reliability of the Patient Health Questionnaire-8 in Swedish for individuals with systemic sclerosis

et al. 2020

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Background Depressive symptoms are common in rheumatic diseases and influence patients’ quality of life. The Patient Health Questionnaire-9 (PHQ-9), which assesses symptoms of depression, is valid in English in patients with systemic sclerosis (SSc). However, the measurement properties of the PHQ-8 (short version of the PHQ-9) have not been evaluated in Swedish patients with SSc. Objective To investigate different aspects of validity and reliability of the PHQ-8 in Swedish (PHQ-8 Swe) for individuals with SSc. Methods A total of 101 patients with SSc participated. Content validity was evaluated via interviews of 11 patients and 10 health professionals. Construct validity, internal consistency test–retest reliability, and floor/ceiling effects were evaluated in 90 patients. Results Content validity was satisfactory, but some linguistic adjustments were made. Confirmatory factor analysis supported a better fit for a two-factor structure. Moderate-to-strong correlations were found between the PHQ-8 Swe and scleroderma HAQ including VAS ( r s = 0.4–0.7); Multidimensional Assessment of Fatigue ( r s = 0.7); RAND-36 subscales ( r s = − 0.5 to − 0.8); and lung disease severity (Medsger scores) ( r s = 0.4). There were weak correlations ( r s = <0.4) between the PHQ-8 Swe and modified Rodnan skin score; and vascular, heart, and kidney disease severity. Cronbach’s alpha was 0.85, corrected item-to-total correlations were >0.40, and the ICC for the total score was 0.83. No floor/ceiling effects were found. Conclusion The PHQ-8 Swe has satisfactory content validity and sufficient reliability in patients with in majority limited SSc. It is more strongly associated with self-reported disability, pain, disease interferences with daily activities, fatigue, and quality of life than with disease severity, except for a moderate association with lung severity.

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“…Emotional suppression was found to be a dysfunctional emotion regulation strategy, while cognitive reappraisal was found to be adaptive ( Werner and Gross, 2010 ). Although research has demonstrated a possible temporal association between psychological distress and onset, recurrence, and severity of psoriasis ( Stewart et al, 2018 ), as well as the presence of high levels on negative affect in SSc patients ( Leon et al, 2014 ), few studies have examined whether expressive suppression or cognitive reappraisal predicted well-being or psychological distress in dermatological patients. For example, Chung et al (2018) have found that the suppression of depression predicted psychiatric co-morbidity in patients with chronic idiopathic urticaria, suggesting the important role of expressive suppression in skin diseases.…”

Section: Introductionmentioning

confidence: 99%

Positive Psychological Factors Are Associated With Better Spiritual Well-Being and Lower Distress in Individuals With Skin Diseases

et al. 2020

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In this study we examined whether aspects of positive functioning [reappraisal, sense of coherence (SOC), and positivity] were associated with spiritual well-being and psychological distress after controlling for negative functioning (skin-related symptoms, type of disease, and expressive suppression) in individuals with skin diseases. We also examined whether negative functioning aspects were linked to spiritual well-being and distress when controlling for aspects of positive functioning. The study used a cross-sectional design with a sample of 192 individuals with psoriasis and systemic sclerosis (SSc) ( M age = 51.6 years, SD = 16.5). Two hierarchical multiple regressions were conducted to determine whether spiritual well-being and psychological distress were accounted for by skin-related symptoms, type of disease, emotion regulation strategies, SOC, and positivity. Positivity was the most important contributor to better spiritual well-being, followed by both the comprehensibility/manageability and meaningfulness SOC subscales, after controlling for the other variables. High skin-related symptoms and expressive suppression were associated with lower psychological distress, whereas high SOC and reappraisal correlated with higher psychological distress. The findings of this study pave the way for further research on how SOC and positivity may reduce the effects of both skin-related symptoms and emotion dysregulation and facilitate spiritual well-being of individuals with skin diseases. Interventions aimed to enhance inner resources of these individuals and help them to find a meaning in their experience of skin disease might reduce psychological distress and improve spiritual well-being. Our findings suggest that healthcare professionals should consider positive functioning aspects in future interventions for individuals with skin diseases.

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Negative affect in systemic sclerosis

Cited by 14 publications

References 57 publications

Phenotyping Exercise Limitation in Systemic Sclerosis: The Use of Cardiopulmonary Exercise Testing

Phenotyping Exercise Limitation in Systemic Sclerosis: The Use of Cardiopulmonary Exercise Testing

Validity and reliability of the Patient Health Questionnaire-8 in Swedish for individuals with systemic sclerosis

Positive Psychological Factors Are Associated With Better Spiritual Well-Being and Lower Distress in Individuals With Skin Diseases

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