Nefropatía C1q en un paciente de 17 años: Caso clínico

Panuncio, Ana; Alba, A.; Bacigalupe, Claudia; Caorsi, Hena; Schwedt, Emma; Otatti, Gabriela; Saralegui, Patricia; Mariño, Ana

doi:10.4067/s0034-98872008001000011

Cited by 2 publications

(6 citation statements)

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“…In front of having risks of recurrence such as rapid initial deterioration and young age, the risk of recurrence is still high and should be followed more closely mainly the first year after receiving the kidney [8,9]. This case was compared to three previously reported cases [4,10,11] (Table 3): The clinical presentation is variable from patient to another, thus, not all patients have kidney failure or decreased renal function upon presentation, as well as for high blood pressure or decreased urine output which were not necessarily found in all patients [4,10,11]. Proteinuria is an important finding, all reported patients had proteinuria but hematuria was not found in all patients.…”

Section: Discussionmentioning

confidence: 99%

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A case report: 19-year-old male diagnosed with C1q nephropathy requiring renal replacement therapy

Choueiri

Faddoul

Ghorra

et al. 2022

Exploration of Medicine

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C1q nephropathy is a rare glomerular disease. Clinical presentation is diverse and ranges from asymptomatic hematuria or proteinuria to symptoms and signs of nephrotic/nephritic syndrome. On light microscopy, it can be classified into two subtypes: minimal change disease (MCD)/focal segmental glomerulosclerosis (FSGS) group and immune complex mediated proliferative glomerulonephritis group. A case of a 19-year-old male patient presenting nausea and decreased appetite will be reported. The labs showed severe nephrotic syndrome and a progressive kidney injury over a few months that were never diagnosed. The immune workup came back negative. The patient mentioned that he was taking protein shakes a few months earlier for bettering his physical fitness. A renal biopsy was done and showed a major reduction in renal mass and C1q nephropathy. He received steroids without any improvement. He was started on hemodialysis afterward then got transplanted 8 months later. In front of this rapid deterioration, FSGS might be the underlying etiology rather than MCD. Further studies are warranted to establish a connection between protein supplements, and progression of kidney disease.

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Section: Discussionmentioning

confidence: 99%

“…The biopsy was the most important and helpful investigation to be done in all reported cases; it is the cornerstone to confirm the diagnosis, by identifying C1q deposits [4,10,11]. However, the treatment was very different between all cases, and each patient responded to a certain type of therapy.…”

Section: Discussionmentioning

confidence: 99%

A case report: 19-year-old male diagnosed with C1q nephropathy requiring renal replacement therapy

Choueiri

Faddoul

Ghorra

et al. 2022

Exploration of Medicine

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“…Los pacientes con GNPM sin SN habitualmente tienen una evolución benigna, los con GSFS tienen un curso arrastrado, pobre respuesta a esteroides y pueden desarrollar una falla renal terminal, aunque hay casos con remisión espontánea 2,3,10 . Algunos pacientes con SN y un patrón de NCM en la BpR inicial pueden desarrollar una GSFS durante su evolución 11 .…”

Section: Discussionunclassified

“…Usualmente se manifestaba como SN resistente a corticoides 1 . Desde entonces se han publicado series y casos clínicos, que han mostrado que esta entidad tiene un comportamiento distinto al SN primario clásico [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] . Otros autores, en cambio, creen que el depósito de C1q es un marcador inespecífico del tráfico de proteínas y que esta entidad está dentro del espectro clínico de las podocitopatías difusas (NCM/GSFS) 19 .…”

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Nefropatía por C1q: una rara variedad de síndrome nefrótico. Caso clínico

et al. 2020

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C1q nephropathy is a rare glomerulopathy characterized by mesangial deposition of the complement component C1q. These deposits can be isolated or associated with immunoglobulins or complement fractions, which are observed by immunofluorescence or immunohistochemical microscopy. In ultramicroscopy, dense mesangial deposits and alterations of the podocyte are observed. Clinically it presents as a nephrotic syndrome (NS) or by alterations of the urinalysis such as proteinuria and/or hematuria in children and young adults. In light microscopy, it is expressed with a morphological pattern of minimal change disease (MCD), mesangial proliferative glomerulonephritis or focal segmental glomerulosclerosis (FSGS). The NS during its evolution usually evolve in steroid resistance or steroid dependency, often requiring the association of immunosuppressants to obtain remission. We report a 14 years old male with a history of NS and its evolution under various treatments during a 12-year follow-up.

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Nefropatía C1q en un paciente de 17 años: Caso clínico

Abstract: C1q nephropathy (C1q N) is an infrequent disease and only about 100 cases have been reported. It is defined by a pattern of immunofluorescense (IF) with (Rev Méd Chile 2008; 136: 1307-10

Cited by 2 publications

References 9 publications

A case report: 19-year-old male diagnosed with C1q nephropathy requiring renal replacement therapy

A case report: 19-year-old male diagnosed with C1q nephropathy requiring renal replacement therapy

Nefropatía por C1q: una rara variedad de síndrome nefrótico. Caso clínico

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