Neferine and isoliensinine enhance ‘intracellular uptake of cisplatin’ and induce ‘ROS-mediated apoptosis’ in colorectal cancer cells – A comparative study

Manogaran, Prasath; Beeraka, Narasimha M; Huang, Chih‐Yang; Padma, Viswanadha Vijaya

doi:10.1016/j.fct.2019.110652

Cited by 27 publications

(23 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, NEF is the best chemotherapeutic active drug to resist various types of cancer such as in liver, colorectal, and breast cancer cells 42‐45 . 42 Poornima et al, 42 discovered NEF 15 mg/kg.bw treated HepG2 cells showed upregulated the Bax & Bad apoptotic protein expressions while downregulated the Bcl‐2 protein.…”

Section: Discussionmentioning

confidence: 99%

Chemomodulatory effect of neferine on DMBA‐induced squamous cell carcinogenesis: Biochemical and molecular approach

Wang

Yuan

et al. 2020

Environmental Toxicology

View full text Add to dashboard Cite

Background Neferine (NEF) is nontoxic, bisbenzylisoquinoline alkaloid is derived from the seed embryo of lotus, a familiar medicinal plant. Although several mechanisms have been planned, an evident antitumor action pathway of NEF on the oral tumor is still not known. In the current study, we aimed at investigating the protecting effect of NEF against experimental oral carcinoma and clarify its possible mechanism through the induction of apoptosis, proliferation, and inflammatory signaling pathways. Methods The experimental hamsters were divided into four groups (I‐IV) containing six hamsters each. The group I was control group, group II and III hamsters treated with 7,12‐dimethylbenz(a)anthracene (DMBA) (0.5%) alone, thrice in a week for 10 weeks, and group III and IV hamsters received oral supplementation of NEF at a concentration of 15 mg/kg bw. All the hamsters were sacrificed after 16 weeks. Results Our results revealed that DMBA treated hamsters exhibited 100% oral tumor cell formation with high‐tumor incidence (TI), tumor number (TN), tumor volume (TV), decreased levels of antioxidants, increased status of lipid peroxidation (LPO), and modulated the activities of liver marker agents as well as NF‐kB, cell proliferation (PCNA), and p53 proteins. NEF supplementation in DMBA treated hamsters, resulted in delayed lesion synthesis, and brought back the levels of the biochemical parameters. In addition, immunostaining of NF‐kB, PCNA, and p53 showed that they were inhibited by NEF. Conclusion Thus, NEF might be considered a better chemopreventive drug in an experimental model of home‐based primary care (HBPC). More research is necessary to study other pathways implicated in oral carcinomas and their modulation by NEF.

show abstract

Section: Discussionmentioning

confidence: 99%

Chemomodulatory effect of neferine on DMBA‐induced squamous cell carcinogenesis: Biochemical and molecular approach

Wang

Yuan

et al. 2020

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…Mechanistically, combination intervention with isoliensinine and dauricine dramatically elevated the expression of miR-199a accompanied by substantial downregulation of HK2 and PKM2, which repressed glycolysis and increased the chemosensitization of HCC cells. Thus, combinatorial regimens, such as combining phytochemicals with potent anticancer activity with approved chemical drugs, seem to be a beneficial strategy for chemoresistant conditions (Li et al, 2018;Manogaran et al, 2019).…”

Section: Synergistic Anticancer Activitymentioning

confidence: 99%

Isoliensinine: A Natural Compound with “Drug-Like” Potential

Cheng

Zhou

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Isoliensinine, a bisbenzylisoquinoline alkaloid isolated from Nelumbo nucifera Gaertn, exerts a variety of beneficial effects, such as antitumor, cardioprotective, antioxidant, antidepressant, and anti-HIV effects, and ameliorates T2DM with hyperlipidemia and Alzheimer’s disease. In this article, the recent literature on isoliensinine, including its pharmacology, pharmacokinetics, and synthesis and extraction, is summarized. Moreover, possible future prospects and research directions are also discussed. Studies on isoliensinine were found by searching a combination of keywords including “pharmacology,” “pharmacokinetics,” and “synthesis and extraction” in the main databases, including PubMed, Google Scholar, Web of Science, NCBI, and Wan Fang. Many studies have pointed out that a major limitation of isoliensinine is its poor solubility in aqueous media. Considering its advantages and limitations, isoliensinine can be used as a lead compound to develop novel efficient and low-toxicity derivatives. The available literature indicates that isoliensinine displays “drug-like” potential. Additionally, there are many related issues and novel mechanisms that need to be explored.

show abstract

Section: Isoliensinine Induces Cervical Cancer Cell Cycle Arrest and Apoptosis By Inhibiting The Akt/gsk3α Pathwaymentioning

confidence: 99%

“…Isoliensinine is a bisbenzylisoquinoline alkaloid that can be isolated from the seed, fruit and germ of the lotus plant Nelumbo nucifera Gaertn (14)(15)(16). It has a variety of reported anticancer properties (14)(15)(16). Previous studies have reported that isoliensinine can induce apoptosis by suppressing NF-κB signaling in hepatocarcinoma cells, by activating the p38 MAPK/JNK signaling in breast cancer cells, by inducing autophagy in apoptosis-defective mouse embryonic fibroblasts and by promoting synergism with cisplatin in colorectal cancer cells (16)(17)(18).…”

Section: Isoliensinine Induces Cervical Cancer Cell Cycle Arrest and Apoptosis By Inhibiting The Akt/gsk3α Pathwaymentioning

confidence: 99%

Isoliensinine induces cervical cancer cell cycle arrest and apoptosis by inhibiting the AKT/GSK3α pathway

et al. 2021

View full text Add to dashboard Cite

Neferine and isoliensinine enhance ‘intracellular uptake of cisplatin’ and induce ‘ROS-mediated apoptosis’ in colorectal cancer cells – A comparative study

Cited by 27 publications

References 39 publications

Chemomodulatory effect of neferine on DMBA‐induced squamous cell carcinogenesis: Biochemical and molecular approach

Chemomodulatory effect of neferine on DMBA‐induced squamous cell carcinogenesis: Biochemical and molecular approach

Isoliensinine: A Natural Compound with “Drug-Like” Potential

Isoliensinine induces cervical cancer cell cycle arrest and apoptosis by inhibiting the AKT/GSK3α pathway

Contact Info

Product

Resources

About