Neem and Turmeric in the management of Covid Associated Mucormycosis (CAM) derived through network pharmacology

Datta, Sriparna; Sarkar, Indrani; Sen, Gargi; Sen, Arnab

doi:10.1080/07391102.2022.2048077

Cited by 6 publications

(9 citation statements)

References 53 publications

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“…Covid Associated Mucormycosis (CAM) management strategies with the phytocompounds such as turmeric and neem are proposed in this network pharmacological study. The outcome revealed Quercetin, an active phytocompound, effectively works against Mucormycosis ( Datta et al, 2023 , Malabadi et al, 2021 , Sekar et al, 2022 ). In a pharmacoinformatics study, the bioactive components of Glycyrrhiza glabra are examined for consideration as a potential inhibitor of SARS-CoV-2 glycoprotein.…”

Section: Discussionmentioning

confidence: 99%

In silico network pharmacology study on Glycyrrhiza glabra: Analyzing the immune-boosting phytochemical properties of Siddha medicinal plant against COVID-19

Sekaran

Karthik²,

Varghese

et al. 2024

Functional Proteomics

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Section: Discussionmentioning

confidence: 99%

In silico network pharmacology study on Glycyrrhiza glabra: Analyzing the immune-boosting phytochemical properties of Siddha medicinal plant against COVID-19

Sekaran

Karthik²,

Varghese

et al. 2024

Functional Proteomics

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“…Strategies involving AI in antifungal development include the following: Integrated AI systems for predicting, diagnosing, and managing mucormycosis among patients of high-risk group. − AI in fungal genomics and drug target identification : Functional genomics approaches using data sets from genomics, transcriptomics, and proteomics are used to identify virulent factors between virulent and avirulent strains . For instance, high cotH gene copy numbers are linked to increased virulence.…”

Section: Insights From In Silico Studiesmentioning

confidence: 99%

“…Their analysis revealed a triple attack strategy against fungal pathogens: inhibiting necrosis, chelating iron, and boosting the immune system. 246 Strategies involving AI in antifungal development include the following:…”

Section: ■ Insights From In Silico Studiesmentioning

confidence: 99%

“…Datta et al used functional network analysis and molecular docking, identifying Quercetin, present in Neem and Turmeric, as a highly effective phytochemical against Mucormycosis, along with Caffeic acid, Curcumin, Kaempferol, Tetrahydrocurcumin, and Myricetin. Their analysis revealed a triple attack strategy against fungal pathogens: inhibiting necrosis, chelating iron, and boosting the immune system …”

Section: Insights From In Silico Studiesmentioning

confidence: 99%

“…Integrated AI systems for predicting, diagnosing, and managing mucormycosis among patients of high-risk group. − …”

Section: Insights From In Silico Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Comprehensive Review on the Virulence Factors and Therapeutic Strategies with the Aid of Artificial Intelligence against Mucormycosis

Tanwar,

Singh,

Singh

et al. 2024

ACS Infect. Dis.

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Mucormycosis, a rare but deadly fungal infection, was an epidemic during the COVID-19 pandemic. The rise in cases (COVID-19-associated mucormycosis, CAM) is attributed to excessive steroid and antibiotic use, poor hospital hygiene, and crowded settings. Major contributing factors include diabetes and weakened immune systems. The main manifesting forms of CAM�cutaneous, pulmonary, and the deadliest, rhinocerebral� and disseminated infections elevated mortality rates to 85%. Recent focus lies on small-molecule inhibitors due to their advantages over standard treatments like surgery and liposomal amphotericin B (which carry several long-term adverse effects), offering potential central nervous system penetration, diverse targets, and simpler dosing owing to their small size, rendering the ability to traverse the blood−brain barrier via passive diffusion facilitated by the phospholipid membrane. Adaptation and versatility in mucormycosis are facilitated by a multitude of virulence factors, enabling the pathogen to dynamically respond to various environmental stressors. A comprehensive understanding of these virulence mechanisms is imperative for devising effective therapeutic interventions against this highly opportunistic pathogen that thrives in immunocompromised individuals through its angio-invasive nature. Hence, this Review delineates the principal virulence factors of mucormycosis, the mechanisms it employs to persist in challenging host environments, and the current progress in developing small-molecule inhibitors against them.

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Mucormycosis: A Serious Catastrophe Involving COVID-19 Patients

Dangi,

Mehendiratta,

Sharma

2023

COVID

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With the global pandemic, COVID-19, spurred on by the "Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2)," India has been greatly impacted. With a rare fungus known as Mucormycosis, the second wave of COVID-19 significantly impacted the Indian population after the initial phase. Mucormycosis is also known as "black fungus" because of the necrosis of infected skin tissue, which causes it to become black. It is caused by Mucoromycetes, members of the Zygomycetes order and the Mucorales class. COVID-19's effects on various comorbid ailments, such as diabetes, heart problems, and immune-compromised states, range from mild to severe to life-threatening. Mucormycosis moulds are more likely to affect patients who have hyperglycemia, ketoacidosis, solid organ or bone marrow transplantation, liver cirrhosis, or neutropenia. To eliminate Mucormycosis, four primary variables must be addressed: early diagnosis, eradication of predisposing factors, prompt antifungal treatment with surgical removal of all diseased tissues, and adjuvant therapies. Here, the present review discusses the clinical aetiology, symptoms, diagnosis, and therapy for black fungus. The study leads to the conclusion that the use of immunosuppressant medication to combat Covid-19 also elevates the possibility of being infected with mucormycotic.

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Neem and Turmeric in the management of Covid Associated Mucormycosis (CAM) derived through network pharmacology

Cited by 6 publications

References 53 publications

In silico network pharmacology study on Glycyrrhiza glabra: Analyzing the immune-boosting phytochemical properties of Siddha medicinal plant against COVID-19

In silico network pharmacology study on Glycyrrhiza glabra: Analyzing the immune-boosting phytochemical properties of Siddha medicinal plant against COVID-19

Comprehensive Review on the Virulence Factors and Therapeutic Strategies with the Aid of Artificial Intelligence against Mucormycosis

Mucormycosis: A Serious Catastrophe Involving COVID-19 Patients

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