Neel Effect: Exploiting the Nonlinear Behavior of Superparamagnetic Nanoparticles for Applications in Life Sciences up to Electrical Engineering

Lenglet, Luc; Motte, Laurence

doi:10.1016/b978-0-12-813594-5.00008-4

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…A solution for a fast and effective quantification of nanoparticles' internalization within cells can be provided by a benchtop magnetic device first developed by Nikitin et al and further explored for applications ranging from electrical engineering to life science [45,46]. The physical concept is to expose the superparamagnetic nanoparticles to a two-frequency magnetic field and the resulting nonlinear magnetization of the nanoparticles generates a response signal which is strictly proportional to the quantities of magnetic nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Real-time in situ magnetic measurement of the intracellular biodegradation of iron oxide nanoparticles in a stem cell-spheroid tissue model

et al. 2020

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The use of magnetic nanoparticles in nanomedicine keeps expending and, for most applications, the nanoparticles are internalized in cells then left within, bringing the need for accurate, fast, and easy to handle methodologies to assess their behavior in the cellular environment. Herein, a benchtop-size magnetic sensor is introduced to provide real-time precise measurement of nanoparticle magnetism within living cells. The values obtained with the sensor, of cells loaded with different doses of magnetic nanoparticles, are first compared to conventional vibrating sample magnetometry (VSM), and a strong correlation remarkably validates the use of the magnetic sensor as magnetometer to determine the nanoparticle cellular uptake. The sensor is then used to monitor the progressive intracellular degradation of the nanoparticles, over days. Importantly, this real-time in situ measure is performed on a stem cell-spheroid tissue model and can run continuously on a same spheroid, with cells kept alive within. Besides, such continuous magnetic measurement of cell magnetism at the tissue scale does not impact either tissue formation, viability, or stem cell function, including differentiation and extracellular matrix production.

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Section: Introductionmentioning

confidence: 99%

Real-time in situ magnetic measurement of the intracellular biodegradation of iron oxide nanoparticles in a stem cell-spheroid tissue model

et al. 2020

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“…[38] While an alternating magnetic field is supplied to SPMNPs, the magnetization modulation causes an electric signal to be inducted, which may be picked up by electromagnetic pickup coils. [39] No interference signals are formed at the higher harmonics produced by the nonlinearity of the SPMNP signal [40][41][42] because interference only occurs at the excitation frequency/fundamental frequency f 0 . [40][41][42] The MPI only needs a few tens of milli-Tesla to excite these magnetic tracers (i.e., SPM-NPs) because their magnetization is 10 8 times larger than nuclear paramagnetism of water in 1.5 T MRI scanner and their Brownian relaxation is 10 4 times faster than T1 relaxation of water in MRI.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review on magnetic imaging techniques for biomedical applications

Mukhatov

Pham

et al. 2023

Nano Select

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This article presents a comprehensive review of current Magnetic Imaging Techniques (MIT), specifically Magnetic Particle Imaging (MPI) and Magnetic Resonance Imaging (MRI) methods as well as their impacts and potential in biomedical applications.The paper particularly focuses on several perspectives of MPI and MRI techniques including technical considerations, advantages, limitations, applications, future trends. Surprisingly, there are not many review articles that focused on MPI and MRI. This review will give a complete overview of present technology, perspectives, and potential future developments for MPI and MRI. MIT has become an essential and integral part of medical diagnosis in many large medical clinics and hospitals. This area is rapidly developing and evolving to meet the huge demands in medical diagnosis and prevention. MPI and MRI are promising technologies that provide reliable and effective diagnosis for many diseases including cancer. MIT uses non-invasive scanning to obtain a detailed image of the body's tissues or organs without the necessity for surgery. These techniques allow us to detect symptoms of serious diseases at an early stage. Early detection also gives patients the chance to get the right care before their illnesses advance to a late, incurable stage, potentially saving many lives.

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In-situ WAXS and SAXS microstructural investigation of Poly(vinylidene fluoride)- Fe3O4 coaxial-electrospun nanocomposites under thermal and mechanical loading: Nanoparticles size effects on fibers molecular orientation, mechanical properties and crystalline polymorphs

Navarro Oliva,

Murthy,

Lenglet

et al. 2024

Polymer

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Neel Effect: Exploiting the Nonlinear Behavior of Superparamagnetic Nanoparticles for Applications in Life Sciences up to Electrical Engineering

Cited by 4 publications

References 42 publications

Real-time in situ magnetic measurement of the intracellular biodegradation of iron oxide nanoparticles in a stem cell-spheroid tissue model

Real-time in situ magnetic measurement of the intracellular biodegradation of iron oxide nanoparticles in a stem cell-spheroid tissue model

A comprehensive review on magnetic imaging techniques for biomedical applications

In-situ WAXS and SAXS microstructural investigation of Poly(vinylidene fluoride)- Fe3O4 coaxial-electrospun nanocomposites under thermal and mechanical loading: Nanoparticles size effects on fibers molecular orientation, mechanical properties and crystalline polymorphs

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