Needling with 5-fluorouracil for encapsulated blebs after Ahmed glaucoma valve implantation

Erdem, Burak; İmamoğlu, Serhat; Erçalık, Nimet Yeşim

doi:10.1080/15569527.2019.1650060

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…It suppresses cell proliferation for approximately 2 weeks and blocks RNA synthesis and vascular endothelial growth factor antibodies [8]. Subconjunctival application of 5-FU in the postoperative period inhibits fibrocyte division and improves long-term prognosis by prolonging the hypotensive effect both in traditional filtering surgery, in various variants of drainage, and in valve glaucoma surgery [9][10][11][12][13]. According to data from randomised trials, the subconjunctival use of 5-FU reduced the risk of filtering surgery failure from 50% to 27% in the high-risk group during the first year of follow-up [14].…”

Section: Introductionmentioning

confidence: 99%

An easy and safe method of subconjunctival injection of antimetabolites in glaucoma surgery

Svetozarskiy,

Andreev,

Shvaikin

et al. 2023

Exploration of Medicine

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Aim: The use of 5-fluorouracil in glaucoma surgery is associated with a high risk of corneal complications, as even minimal doses of the drug at the ocular surface inhibit corneal epithelial cell division and lead to corneal epitheliopathy and erosion. The aim of this study was to evaluate the clinical and functional results of the proposed method of postoperative adjuvant subconjunctival injection of 5-fluorouracil after non-penetrating deep sclerectomy (NPDS) in comparison with the control group. Methods: Patients with primary open-angle glaucoma who underwent NPDS and received at least 1 subconjunctival injection of 5-fluorouracil in the postoperative period were included in a two-group retrospective comparative study. Patients who received a subconjunctival injection of 5-fluorouracil after surgery using the standard technique were included in Group 1; Group 2 included patients who received an injection using the proposed method. Best-corrected visual acuity (BCVA), intraocular pressure (IOP), rate of corneal complications, and number of office visits during the first 4 weeks after surgery were analysed. Results: The compared groups did not differ in demographic characteristics, preoperative BCVA, and IOP parameters. Fluorescein-stained corneal epithelial defects were statistically significantly more frequent in Group 1 compared to Group 2, P < 0.001. Four weeks post NPDS IOP reduction was greater in Group 2, P = 0.042. Mean BCVA loss was 1.9 lines in Group 1 and 1.3 lines in Group 2, P < 0.001. The number of follow-up visits during the first month after surgery was lower in Group 2 than in Group 1, P = 0.002. Conclusions: The proposed method was simple and effective in reducing the risk of corneal epithelial defects after subconjunctival injection of 5-fluorouracil, significantly improving clinical and functional outcomes of NPDS and reducing the need for outpatient visits.

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Section: Introductionmentioning

confidence: 99%

An easy and safe method of subconjunctival injection of antimetabolites in glaucoma surgery

Svetozarskiy,

Andreev,

Shvaikin

et al. 2023

Exploration of Medicine

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“…15,16 These following procedures were used to attempt to control IOP in failure of GDD: implantation of the second GDD, which was reported to have a cumulative failure rate at three years of 32.5%, 22 transscleral cyclophotocoagulation procedure which was equally effective as the second GDD with cumulative success rates at one year of 88% and 79%, respectively 23 and needling revision of the glaucoma drainage device filtering bleb which were reported as 43% to 72.2% cumulatively for both complete and qualified success at 24 months. [24][25][26]…”

mentioning

confidence: 99%

Surgical Outcomes of Glaucoma Drainage Device Implantation in Refractory Glaucoma Patients in Thailand

Rojananuangnit¹,

Jiaranaisilawong²,

Rattanaphaithun³

et al. 2022

OPTH

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Purpose To study the surgical outcomes of glaucoma drainage device (GDD) implantation in refractory glaucoma patients. Patients and Methods Retrospective chart review of glaucoma patients undergoing GDD implantation, Ahmed glaucoma valve (AGV), Baerveldt glaucoma implants (BGI), and Aurolab aqueous drainage implantation (AADI) from January 2012 to June 2021. Glaucoma patients were classified into two groups: primary glaucoma including: primary open angle glaucoma (POAG), primary angle closure glaucoma (PACG) and juvenile open angle glaucoma (JOAG) and secondary glaucoma including: neovascular glaucoma (NVG), ocular surgery (vitreoretinal surgery, scleral buckling procedure, postoperative extra capsular cataract extraction, scleral fixation intraocular lens, penetrating keratoplasty), intraocular trauma, uveitis glaucoma, lens-induced glaucoma, pseudoexfoliation glaucoma (PXG), iridocorneal endothelial (ICE) syndromes and Axenfeld Rieger Syndrome. Surgical outcomes were studied. Results Primary glaucoma included 57 eyes from 49 patients. Secondary glaucoma included 87 eyes from 85 patients. The cumulative probability of complete or qualified success of refractory glaucoma patients at five years were 53.4% (95%CI: 38.4%, 66.3%). Higher success rate was discovered in primary glaucoma at 65.8% (95%CI: 38.4%, 83.3%) than 45.2% (95%CI: 26.9%, 61.9%) in secondary glaucoma group significantly with p =0.003. While the results among success rate, adverse events and complications was not different between types of GDD. Predictors for failure were neovascular glaucoma with unadjusted hazard ratio (HR) 3.62 (95%CI: 1.45, 9.04) with p =0.006, and lens-induced glaucoma with adjusted HR 4.19 (95%CI: 1.10, 15.86) with p =0.035 in multivariable analysis. Tube malposition and occlusion were the most frequent adverse events at 11.11%, corneal decompensation at 5.5%, hypotony at 2% in the nonvalved group, and endophthalmitis at 0.69%. Conclusion Surgical success in refractory primary glaucoma was superior to secondary glaucoma with no difference between nonvalved and valved GDD implantation. Lens-induced glaucoma was a strong predictor for failure in GDD implantation.

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The role of primary needle revision after Ahmed glaucoma valve (AGV) implantation

2020

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Needling with 5-fluorouracil for encapsulated blebs after Ahmed glaucoma valve implantation

Cited by 5 publications

References 27 publications

An easy and safe method of subconjunctival injection of antimetabolites in glaucoma surgery

An easy and safe method of subconjunctival injection of antimetabolites in glaucoma surgery

Surgical Outcomes of Glaucoma Drainage Device Implantation in Refractory Glaucoma Patients in Thailand

The role of primary needle revision after Ahmed glaucoma valve (AGV) implantation

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