Needlestick injury: Blood, mononuclear cells, and acquired immunodeficiency syndrome

Shirazian, Djamshid; Herzlich, Barry C.; Mokhtarian, Foroozan; Spatoliatore, Giuseppe; Grob, David

doi:10.1016/s0196-6553(05)80179-8

Cited by 17 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A series of two doses of this post-exposure intervention, given as otomy needle was substantially higher than from a suture needle of comparable size. Shirazian et al (1992) found soon as possible after the exposure and repeated 1 month later, is 75% effective in preventing HBV infection (CDC that the volume of blood conveyed from a 20-gauge needle was 30 times greater than the amount from a 27-gauge 1990). Alternatively, a single dose of hepatitis B immune globulin plus a series of hepatitis B vaccine may be needle.…”

Section: Hiv Infectionmentioning

confidence: 99%

A Critical review of the literature on sharps injuries: epidemiology, management of exposures and prevention

Hanrahan

Reutter

1997

Journal of Advanced Nursing

View full text Add to dashboard Cite

This article reviews the literature related to the epidemiology, prevention and management of sharps injuries in health care workers, particularly nurses, and the subsequent risk of harm. The studies are reviewed chronologically, beginning with the efforts to reduce sharps injuries by changing behaviours, followed by the introduction of barriers to protect the caregiver, and finally, the engineering of safer products. Initial efforts to prevent sharps injuries focused on placing rigid, disposal containers at the site where sharps were used and instructing health care workers to refrain form the practice of recapping. When these interventions were shown to alter the type, but not the overall number, of sharps injuries, alternative measures were sought. This search intensified with the increasing evidence of the small, but measurable, risk of the transmission of human immunodeficiency virus from sharps injuries. The current knowledge of the factors related to sharps injuries has been collected primarily through retrospective surveillance. This surveillance has been conducted primarily in hospital settings and has focused on the type of sharp and the purpose for which it was used rather than prospective research. Research is now needed to elucidate the organizational and behavioural factors leading to sharps injury both within the hospital as well as other health care settings. The implications for nursing practice are discussed.

show abstract

Section: Hiv Infectionmentioning

confidence: 99%

A Critical review of the literature on sharps injuries: epidemiology, management of exposures and prevention

Hanrahan

Reutter

1997

Journal of Advanced Nursing

View full text Add to dashboard Cite

show abstract

“…The transmission of HIV from an AIDS patient to a health care worker by accidental needlesticks, wounds with sharp instruments, and contamination of mucous membranes or broken skin with contaminated blood from a HIV-infected patient has been well documented (Weiss et al , 1985;Tulis, 1987;Piaazza et al , 1989;Bailey, 1990;Heald and Ransohoff, 1990;Vaughn et al , 1990;Klatt and Noguchi, 1990;Beekmann et al, 1990;Speller et al , 1990;Beck and Martin, 1990;Rhame, 1992). The volume of blood and number of cells transferred by a needlestick with a needle contaminated with HIV-positive blood were quantitated by Shirazian et al (1992). In tests of needles ranging from 20 to 27 gauge, it was found that 300 to 400 nL of blood were transferred by a needlestick, and at least one viable lymphomononuclear cell was transferred 68% to 96% of the time.…”

Section: Literature Reviewmentioning

confidence: 99%

Characterization of aerosols produced by surgical procedures

Yeh¹,

Muggenburg²,

Lundgren³

et al. 1994

View full text Add to dashboard Cite

show abstract

Occupational Toxicology in the Pharmaceutical Industry

Dolan

Bercu

Graham³

et al. 2023

Patty's Toxicology

View full text Add to dashboard Cite

Much of the activity in the pharmaceutical industry has its origins in the fine chemicals industry of the late nineteenth century. At that time, advances in chemistry and medicine led to the manufacture of pharmacologically active small molecules to produce desirable biological effects to treat diseases and illnesses at relatively low doses. Advances in biology and chemistry in the past quarter century have led to an increase in innovation resulting in a variety of novel modalities, especially recombinant proteins, antibody‐drug conjugates, cell and gene therapies, peptides and polypeptides, oligonucleotides, and vaccines. The roles and responsibilities of occupational toxicologists in the pharmaceutical industry have expanded dramatically in the twenty‐first century, commensurate with the changing regulatory requirements and treatment modalities. The occupational toxicologists' roles have become increasingly multidisciplinary and the scope of their involvement has expanded to encompass diverse aspects of worker safety as well as patient safety, and to include involvement throughout a molecule's development, from early development through postcommercialization.

show abstract

Needlestick injury: Blood, mononuclear cells, and acquired immunodeficiency syndrome

Cited by 17 publications

References 6 publications

A Critical review of the literature on sharps injuries: epidemiology, management of exposures and prevention

A Critical review of the literature on sharps injuries: epidemiology, management of exposures and prevention

Characterization of aerosols produced by surgical procedures

Occupational Toxicology in the Pharmaceutical Industry

Contact Info

Product

Resources

About