Needleless electrospun carboxymethyl cellulose/polyethylene oxide mats with medicinal plant extracts for advanced wound care applications

Maver, Tina; Kurečič, Manja; Pivec, Tanja; Maver, Uroš; Gradišnik, Lidija; Gašparič, Petra; Kaker, Barbara; Bratuša, Ana; Hribernik, Silvo; Kleinschek, Karin Stana

doi:10.1007/s10570-020-03079-9

Cited by 51 publications

(27 citation statements)

References 59 publications

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“…Moreover, the band at 840 cm −1 was attributed to the stretching vibration of the molecular bond C–O–C and the C–C. These results were in close agreement with those observed in previous works [ 58 , 71 , 76 , 83 , 86 , 87 ]. The FTIR spectra of PEO/AVE nanofibers showed the characteristic AVE absorbance peaks at 1745 and 1603 cm −1 ( Figure 2 b), with higher intensity with increasing AVE content in the polymer formulations used for nanofibers production.…”

Section: Resultssupporting

confidence: 92%

“…Several parameters could affect the fibres production process by electrospinning technique, which have to be rigorously controlled to obtain materials with desired characteristics [ 50 , 51 ]: Processing (applied voltage, distance between the tip of the needle and the collector and flow rate), solution (solvent, concentration, viscosity, conductivity) and environmental (temperature, relative humidity) parameters. A wide range of natural extracts with antioxidant activity, such as rosemary extract [ 52 , 53 ], grape seed extract [ 54 , 55 , 56 ], Momordica charantia fruit extract [ 57 ], medicinal plant extracts [ 58 ], pomegranate peel extract [ 59 ], yerba mate extract [ 60 ], garlic extract [ 42 ] and liquorice extract [ 43 ], were encapsulated in electrospun fibres. In addition, Aloe Vera inner gel extract was recently incorporated in different polymer matrices by electrospinning technique for several applications, mainly related to wound healing and skin tissue engineering, due to its intrinsic healing properties.…”

Section: Introductionmentioning

confidence: 99%

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Encapsulation of Bioactive Compounds from Aloe Vera Agrowastes in Electrospun Poly (Ethylene Oxide) Nanofibers

et al. 2020

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Aloe Vera is an ancient medicinal plant especially known for its beneficial properties for human health, due to its bioactive compounds. In this study, nanofibers with antioxidant activity were successfully obtained by electrospinning technique with the addition of a natural Aloe Vera skin extract (AVE) (at 0, 5, 10 and 20 wt% loadings) in poly(ethylene oxide) (PEO) solutions. The successful incorporation of AVE into PEO was evidenced by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (ATR-FTIR), thermogravimetric analysis (TGA) and antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH), 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging (ABTS) and ferric reducing power (FRAP) assays. The incorporation of AVE introduced some changes in the PEO/AVE nanofibers morphology showing bimodal diameter distributions for AVE contents in the range 10-20 wt%. Some decrease in thermal stability with AVE addition, in terms of decomposition onset temperature, was also observed and it was more evident at high loading AVE contents (10 and 20 wt%). High encapsulation efficiencies of 92%, 76% and 105% according to DPPH, FRAP and ABTS assays, respectively, were obtained at 5 wt% AVE content, retaining AVE its antioxidant capacity in the PEO/AVE electrospun nanofibers. The results suggested that the obtained nanofibers could be promising materials for their application in active food packaging to decrease oxidation of packaged food during storage.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Encapsulation of Bioactive Compounds from Aloe Vera Agrowastes in Electrospun Poly (Ethylene Oxide) Nanofibers

et al. 2020

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“…The peaks at 1209 cm −1 and 1249 cm −1 were assigned to the S–C–H bending. An intensive and broad absorption band at 3200–3400 cm −1 for the 3D-printed coatings indicates the presence of O–H vibrations and the formation of hydrogen bonds, while the peak at around 1630 cm −1 most likely corresponds to the carboxylate in carboxymethyl cellulose [ 36 ]. The ATR-FTIR spectrum of CLIN-functionalised (ES and 3D-printed) polymer coatings showed no new functional peaks in either of the spectra, thus revealing that no new chemical bonds were formed between the drug and the polymer mixtures.…”

Section: Resultsmentioning

confidence: 99%

Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections

et al. 2021

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This study presents the development and characterisation of two novel bioactive coatings deposited on TiAlV and AISI 316LVM substrates. The coatings were prepared using 3D printing and electrospinning. The 3D-printed coating consisted of the cellulose nanofibril suspension, alginate, and carboxymethylcellulose (CMC), while CMC and polyethylene oxide were used to prepare the electrospun coating. Both coatings were loaded with the antibiotic clindamycin (CLIN), which is a bacteriostatic lincosamide known for its activity against streptococci, staphylococci, pneumococci, Bacteroides species, and other anaerobes. Initial characterisation of the coatings was performed by attenuated total reflectance Fourier transform infrared spectroscopy, field emission scanning electron microscopy, and atomic force microscopy. Furthermore, the contact angle measurements, swelling rate, and biodegradability of the coatings were investigated. The released concentration of CLIN in PBS (pH = 7.4 at 25 °C) was determined by UV-VIS spectrophotometry. The coatings’ biocompatibility was determined using an MTT (3(4,5 dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) assay using an osteoblast cell culture (hFOB 1.19, ATCC CRL 11372).

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“…Maver et al addressed the needleless electro-spinning of carboxymethyl cellulose/polyethylene oxide (CMC/PEO)/plant extract blend aqueous solutions for the purpose of fabricating a cellulose-based wound dressing material that would be appropriate for curing severe wounds. The released study and cell viability tests indicated the promising potential of the product to be used for wound care [114]. Jun-Jye Ng and Pitt Supaphol investigated the production of polymer nano-fiber mats through needleless electro-spinning of poly (caprolactone) (PCL), poly (lactic acid) (PLA), and poly (vinyl alcohol) (PVA) [115].…”

Section: Needleless Electro-spinningmentioning

confidence: 99%

Electrospun Nano-Fibers for Biomedical and Tissue Engineering Applications: A Comprehensive Review

et al. 2020

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Pharmaceutical nano-fibers have attracted widespread attention from researchers for reasons such as adaptability of the electro-spinning process and ease of production. As a flexible method for fabricating nano-fibers, electro-spinning is extensively used. An electro-spinning unit is composed of a pump or syringe, a high voltage current supplier, a metal plate collector and a spinneret. Optimization of the attained nano-fibers is undertaken through manipulation of the variables of the process and formulation, including concentration, viscosity, molecular mass, and physical phenomenon, as well as the environmental parameters including temperature and humidity. The nano-fibers achieved by electro-spinning can be utilized for drug loading. The mixing of two or more medicines can be performed via electro-spinning. Facilitation or inhibition of the burst release of a drug can be achieved by the use of the electro-spinning approach. This potential is anticipated to facilitate progression in applications of drug release modification and tissue engineering (TE). The present review aims to focus on electro-spinning, optimization parameters, pharmacological applications, biological characteristics, and in vivo analyses of the electro-spun nano-fibers. Furthermore, current developments and upcoming investigation directions are outlined for the advancement of electro-spun nano-fibers for TE. Moreover, the possible applications, complications and future developments of these nano-fibers are summarized in detail.

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Needleless electrospun carboxymethyl cellulose/polyethylene oxide mats with medicinal plant extracts for advanced wound care applications

Cited by 51 publications

References 59 publications

Encapsulation of Bioactive Compounds from Aloe Vera Agrowastes in Electrospun Poly (Ethylene Oxide) Nanofibers

Encapsulation of Bioactive Compounds from Aloe Vera Agrowastes in Electrospun Poly (Ethylene Oxide) Nanofibers

Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections

Electrospun Nano-Fibers for Biomedical and Tissue Engineering Applications: A Comprehensive Review

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