Needle track seeding after percutaneous radiofrequency ablation of hepatocellular carcinoma: 14-year experience at a single centre

Zhang, Zhong-Yi; Yang, Wei; Yan, Kun; Dai, Ying; Wu, Wei; Lee, Jung‐Chieh; Chen, Minhua

doi:10.1080/02656736.2017.1278630

Cited by 23 publications

(14 citation statements)

References 21 publications

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“…Several authors suggested an increased risk of neoplastic seeding in HCC when ablation techniques were combined with biopsy and recommended to avoid biopsy whenever possible. Increased risk of seeding was also reported when Radiofrequency ablation (RFA) followed biopsy, even when track ablation has been performed [7][8][9]. The time interval between the biopsy and the discovery of the neoplastic seeding also varies greatly due to the quality and duration of patient follow-up.…”

Section: Introductionmentioning

confidence: 99%

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Risk of needle tract seeding after coaxial ultrasound-guided percutaneous biopsy for primary and metastatic tumors of the liver: report of a single institution

et al. 2019

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Purpose The objective of this study was to determine the incidence of needle track seeding after ultrasound-guided percutaneous biopsy of indeterminate liver lesions with a coaxial biopsy system without any other additional intervention or ablation therapy. Methods We identified 172 patients in a retrospective cohort study who underwent ultrasound-guided biopsy due to a liver mass in our institution between 2007 and 2016. The same coaxial biopsy system was used in all patients, no consecutive ablation was performed. Results None of the finally included 131 patients developed neoplastic seeding. There was one major complication (0.76%), the rest of the complications were minor (3.8%) and did not require further intervention. Conclusion Needle track seeding is a rare delayed complication after percutaneous liver biopsy. Coaxial liver biopsy is a safe method to obtain multiple samples with a single punch in patients with primary or metastatic liver lesions.

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Section: Introductionmentioning

confidence: 99%

“…The time interval between the biopsy and the discovery of the neoplastic seeding also varies greatly due to the quality and duration of patient follow-up. Treatment of choice for needle track seeding is radical surgical excision, local radiotherapy, or highintensity-focused ultrasound [8].…”

Section: Introductionmentioning

confidence: 99%

Risk of needle tract seeding after coaxial ultrasound-guided percutaneous biopsy for primary and metastatic tumors of the liver: report of a single institution

et al. 2019

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“…Methods of obtaining histological tissue from the liver such as liver biopsy and EUS-FNA carry a risk of needle-tract seeding in patients with malignant tumors [12,13]. In the present case, the mass in the left lobe of the liver resembled a metastasis from a GB cancer on CT at the time of the first surgery.…”

Section: Discussionmentioning

confidence: 64%

Recurrent Hepatic Inflammatory Pseudotumor in Asynchronism After Surgery of Inflammatory Pseudotumor Associated With Granulomatous Cholangitis

et al. 2019

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A 64-year-old man was referred to our hospital for investigation of thickening of the gallbladder wall and hepatic mass. Repeated endoscopic ultrasound-guided fine-needle aspiration examinations of these lesions excluded malignant diseases. Cholecystectomy and resection of lateral section confirmed xanthogranulomatous cholecystitis and inflammatory pseudotumor (IPT) associated with granulomatous cholangitis. Ten months after surgery, a new lesion appeared in the liver medial section, associated with fluorodeoxyglucose accumulation. After performing resection of the affected segment, recurrent IPT related with granulomatous cholangitis was diagnosed. No subsequent recurrence was seen during follow-up. This represents the first report of recurrent hepatic IPT originating from granulomatous cholangitis after resection of xanthogranulomatous cholecystitis and IPT caused by granulomatous cholangitis.

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“…[10][11][12] Recently, risk of seeding after percutaneous ethanol injection (PEI), radiofrequency ablation (RFA), microwave ablation (MWA) and cryoablation varied from 0.3% to 1.9%, from 0.005% to 12.5%, from 0.44% to 0.75% and 0.76% in previous reports respectively, has received increased attention from clinicians. [13][14][15][16][17][18] Based on appropriate choice by the patient and careful attention to the ablation procedure, several studies showed low seeding rate after ablation. Nevertheless, even if the ablation modalities have been proven to be a relatively safe technique, seeding remains an inevitable ablation-related complication.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a clinicopathological‐based nomogram to predict seeding risk after percutaneous thermal ablation of primary liver carcinoma

Huang

et al. 2020

Cancer Medicine

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Objectives To develop a clinicopathological‐based nomogram to improve the prediction of the seeding risk of after percutaneous thermal ablation (PTA) in primary liver carcinoma (PLC). Methods A total of 2030 patients with PLC who underwent PTA were included between April 2009 and December 2018. The patients were grouped into a training dataset (n = 1024) and an external validation dataset (n = 1006). Baseline characteristics were collected to identify the risk factors of seeding after PTA. The multivariate Cox proportional hazards model based on the risk factors was used to develop the nomogram, which was used for assessment for its predictive accuracy using mainly the Harrell's C‐index and receiver operating characteristic curve (AUC). Results The median follow‐up time was 30.3 months (range, 3.2‐115.7 months). The seeding risk was 0.89% per tumor and 1.5% per patient in the training set. The nomogram was developed based on tumor size, subcapsular, α‐fetoprotein (AFP), and international normalized ratio (INR). The 1‐, 2‐, and 3‐year cumulative seeding rates were 0.1%, 0.7% and 1.2% in the low‐risk group, and 1.7%, 6.3% and 6.3% in the high‐risk group, respectively, showing significant statistical difference (P < .001). The nomogram had good calibration and discriminatory abilities in the training set, with C‐indexes of 0.722 (95% confidence interval [CI]: 0.661, 0.883) and AUC of 0.850 (95% CI: 0.767, 0.934). External validation with 1000 bootstrapped sample sets showed a good C‐index of 0.706 (95% CI: 0.546, 0.866) and AUC of 0.736 (95% CI: 0. 646, 0.827). Conclusions The clinicopathological‐based nomogram could be used to quantify the probability of seeding risk after PTA in PLC.

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Needle track seeding after percutaneous radiofrequency ablation of hepatocellular carcinoma: 14-year experience at a single centre

Abstract: Needle track seeding is a rare delayed complication after percutaneous RFA. Tumour >3 cm, subcapsular tumour, biopsy before RFA and non-cool-tip electrode are potential risk factors for seeding. Local therapies are effective methods for seeding patients.

Cited by 23 publications

References 21 publications

Risk of needle tract seeding after coaxial ultrasound-guided percutaneous biopsy for primary and metastatic tumors of the liver: report of a single institution

Risk of needle tract seeding after coaxial ultrasound-guided percutaneous biopsy for primary and metastatic tumors of the liver: report of a single institution

Recurrent Hepatic Inflammatory Pseudotumor in Asynchronism After Surgery of Inflammatory Pseudotumor Associated With Granulomatous Cholangitis

Development and validation of a clinicopathological‐based nomogram to predict seeding risk after percutaneous thermal ablation of primary liver carcinoma

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